SVR rates confusion

[wyntre9]

Let me say up front I'm confused!

I thought I understood about SVR rates but after reading forum the past few days it occurs to me that I may be interpreting everything a** backwards.

Clarification, PLEEZE!

I'm 1A, not UND by week 12, Und around week 16, currently on 72 week TX.

I thought that 1A's who reached UND by week 12 had at least a 50% chance of SVR by doing 48 week SOC.

I also thought that slow responders (ie; those who reach UND between weeks 12 and 24) had an SVR rate of only 29%.

Therefore, my understanding was that slow responders who extend to 72 weeks TX increase their chances of SVR .....  but to WHAT?

I mean, do the studies say 1A's who extend to 72 weeks have a 50% SVR rate?  Is it 70%?  29%?

Does anyone know?

Wyntre

[wyntre9]

I just read through both links (thank you very much) and realized my mathematical dyslexia combined with regular dyslexia must have somehow translated THIS:

"18 Months Therapy (Pegasys+Ribavirin): study found relapse rate reduced by 70%; viral response rate in genotype 1 increased by 50%"

into MY fantasy cruising on De Nile wish that 72 weeks = 70% SVR whereas 48 weeks = 50% SVR.

Doya think I might have a future in advertising?

wyn

[Bill1954]

Wyntre;

Our posts are crossing; you might have misinterpreted this data that suggests:
~~~~~~~~~~~
“…Among the Week 4 HCV RNA undetectable patients, SVR rates were 79% in the arm treated for 24 weeks (i.e., genotype 2 or 3) and 64% in the arm treated for 48 weeks (i.e., genotype 1)…”
~~~~~~~~~~
Unfortunately, (according to this study, anyway) once a GT-1 patient does *not* achieve UND status by week 4, they start to breath different air. Increasing ones statistical odds from 28% to 44% is enough motivation for me. By the way, I was undetectable to <5 IU/mL by week 8 this treatment… I’m currently extending based on a Hx of prior relapse, as well as my ability to tolerate meds.

I’m doing well, thanks for asking. I’ve got classes 4 days a week right now at the local community college, so I’m staying busy in that department. I do seem to feel apathetic in terms of physical exertion; no running or even walking lately. I mentioned above that I kind of fell in a little hole during the mid-thirties- back on track since week 40, though. I wish you the same, gal.

Take care,

Bill

[jmjm530]

Part of the confusion is that some of the studies listed above used fixed-dose ribavirin (800 mg/day) instead of the weight-based dose many of us use. I haven't reviewed all of the studies lately but I haven't been aware that EVRs (detect at week 4, UND by week 12) who use weight-based ribavrin whould across-the-board extend to 72 weeks. Hey, I was detect at week 4 but UND at week 6 and two prominent liver specialists strongly recommended only 48 weeks. Plus there are other factors that should enter into the equation such as amount of liver damage and how well you're tolerating treatment. On the other side of the coin, if you really feel that the odds drop significantly if your're not UND by week 4, then I think it's just as reasonable to stop treating after 4 weeks as opposed to extrending to 72 weeks in the subset of folks with little or no liver damage. Treating 72 weeks is a long haul with interferon and you just don't know what kind of shape you're going to be left in.

-- Jim

[Bill1954]

Wyntre: too funy!

FL: I'm actually taking second semester Spanish in school; if I had to translate this directly from Madrid, though, I might be arriving with the same stats Wyntre is :-).

[Bill1954]

Thanks for clarifying, Jim;

I was aware of some discrepancies, and was trying to be careful (CMA) by allowing Liz Highleyman to provide the interpretation :o). Yeah, it’s difficult to get apples-to-apples with a lot of this data… it’s almost like ‘pick a position and then find a study to support that position’, huh?

Bill

[wyntre9]

Jm,

I have always looooved, no, treasured your posts but could you Pleeeze make a minor concession to the dyslexic, ADD-afflicted on board and put some friggin PARAGRAPH BREAKS in there!!!!!

i mean, i KNOW it won't technically BE a P. break but it would make it soooo much easier for dolts like me to try and comprehend.

On the other hand, in my case that's obviously futile so why should you bother making that effort?

you're right . . .  

but if i understood your point, it's a good one...  i think. . .

Bill,

You taking classes or giving classes?

Glad you're feeling better, again.  Hope I can say the same sometime soon.

wyn