Telaprivir works

[lab-rat]

I haven't posted in a very long time but I just wanted to share news with those of you who may be following the trial drugs  

I just received my 48-week post treatment test results and I'm negative !!!!!!!!!

I was in the control group (placebo) of the Prove 1 trial for vx-950 and treated for 48 weeks with standard treatment.  I responded well in the beginning but 11 weeks post treatment I relapsed.  So I joined a roll-over trial and treated for a total of 24 weeks - the first 12 with telaprivir - the real thing not the placebo.   I went negative at week 1 and remained that way until the end...and now.  Just wanted to let everyone know that Telaprivir works!

[newleaf09]

I completely agree with you. I randomized out of the boceprevir naive study at 28 wks. and it was a tremendous relief not to worry about more possible damage from long-term interferon.  Though I've never met them, I like my spleen, I like my thyroid.  I want to keep them.

[Rockerforlife]

In the BOC trials,63% get a RVR by week 4 after taking the BOC,,and of that 63%.82% to 92% go on to SVR

[Tippyclubb]

gypsy they will not tell you when you went UND, only that you are by week 24.  The major criteria for getting into the 6 months group is being RVR.  If you are, you have a 50% chance of getting 6 months.  If not, RVR your percentage is very small of making 6 months group.   Two days after my 20th shot they told me what group I was in.  Seems I found out earlier than most?

[Rockerforlife]

you said

I have read studies where the 24 week arm actually had a better SVR rate then the 48 week arm.

you got me thinking...maybe in some cases too much TX may detirmental...too much of a good thing i mean

[copyman]

even if it is a10% which many studies say otherwise. The difference vs the permanent damage that an extra 6 months of peg and riba can do to you is not woth it. For me anyway, others may feel different.

Believe me I have done more research on the Telaprevir 24 vs 48 subject then probably anyone. I have read studies where the 24 week arm actually had a better SVR rate then the 48 week arm.

Bottom line is I did my own private PCR's and was UNDE at 21 days, probably sooner. I did the PCR's every 4 weeks throughout with the most sensitive test available at 24 weeks, the Labcorp NGI UltraQual which measures down to 2 virons.
I elected to do the Telaprevir study over Boceprevir because of the chance of doing only 24 weeks. I knew I had a 50% chance of being randomized to 48 week arm so I did my own PCR's so I could make a decision at 24 weeks.Glad I did. I tx'd an extra 9 weeks to help my chances.
I still have some praying to do to remain SVR

[thegypsy9164]

Well,

I'm on a Telepravir study too.  I did shot #21 yesterday and will not be allowed to find out when I went UND until at or after week 24, which is coming up soon.  I'm excited to know and hopeful.  It sounds like a lot of us on this forum are clearing.  I wonder if it has to do with a positive attitude of participation and education about our disease as well as the new drugs.  No way to measure that right now though eh?

Joey