Sherry, so sorry to hear of your bad news on hubby but happy for you and your SVR. Do you still have his study drugs? He may have been on placebo. If interested, I could send you the lab I used to test my study drugs. This way you would not have to wait three years. Just a thought.
Totally agree with Sandysf...If you can get a lab to tell you what they were/I wouldnt want to wait for 3 years either cindy
I'm very sorry but 355,000 is probably not a false positive, false positives are usually like 60 or something like that.
the good news is if he does take good care of his liver he should have time as a stage 2 but you have to make sure to get a biopsy done on him every few years to monitor the damage. I believe that they say that once we are older the damage can progress faster. It is not linear in nature meaning that it could take 30 years to get to stage 2 but then only 5 to get to cirrhosis. So he has to be extremely good to that liver.
Hopefully the newer new drugs will pan out and lead to SVR and he can try them rather than interferon and riba - we don't know yet how well they will lead to SVR but of course as all interferon haters do......we sure hope so.
Congrats on your SVR I am very very sorry that your husbands treatment did not succeed.
Sherry...I was wondering the other day what had become of you folks .seeing as we hadn't heard from you in awhile.
That is great news on you own results. ..being UND 3 months post tx. you will undoubtedly SVR.
Very sorry to hear about hubby..unfortunately the chances of the PCR being a false positive are low ..especially given the fact he was only UND at week 13 and stopped at week 23.
Good advice from sandy and Eyes of Blue ...if you have some study med left and can get it analyzed it would be good info to have to move forward with possible treatment now(if indeed it is placebo)
Failing that or if it is study drug.. then it is best to wait until he knows what he was taking to be able to treat again.
He is in roughly the same position I and a few others are here....a failed trial experiment and waiting for them to unblind in order to move forward.
You say 3 years?..that seem like an unusually long time for this trial...are you sure it is that long from now?
The rapid or slow onset of returning virus will have no bearing on his progression of liver damage (fibrosis) There are many with low loads with significant damage and vice versus.
On a positive note..as you mentioned he only has moderate damage(St2) and this will allow some time to see how things unfold to be able to treat again..
So.1) if you have drugs left ..try to ge analyzed 2) get then to give you the exact date of study completion and 3) he is stage 2 so no matter what there is time(possibly a significant amount)
Best to you both..
Will
I'm so sorry for your disappointment. My husband has failed TX 3 times and it is most discouraging. I do think it helped his liver a bit even though it wasn't successful
Sending a hug,
Ev
Sorry for your husbands bad news. Good advice from the others. I just want to add not to worry about the study not letting your husband continue the SOC drugs. They most likely wouldn't work at this point anyway.
I would put all the effort into if your husband got the placebo, and if he did then he should re-treat with one of the new PI's that came out earlier this year.
Best of luck
If interested, I used Avomeen Analytical Services. Shri Thanadar, Ph.D was my contact. www.avomeen.com and the number is 800-930-5450
They were responsive, fast and charge $750 per pill.. which for me, if you can afford it was totally worth it! Sandy
sherritaylor
Am I remembering correctly that the whole study was pulled because of adverse effects some of the participants had? You are fortunate, indeed that you are SVR . Many congrats. I was asked to be in that study but declined. At my stage I could not take a chance with the uncertaincys.
I am sorry for your husband's not clearling-- at least that is as it appears. He still has time, but do make sure he gets a biopsy when it has been 3 years. frijole
I'm so happy for your results. I understand the disappointment that you feel about your husband. From talking to my doctor and study coordinator, nearly anyone that had one or both of the study drugs, had success so chances are he was on a placebo. So even though it did not work this time, he can see what happens with the non-interferon treatments. I've said before that interferon was no friend to me either.
@frijole - the study was not pulled, just one of the drugs - Tegobuvir - for its interaction with interferon. The drug is still being tested in all oral studies and this particular study is still going on with the other study drug as yet unnamed.