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Why do some fail Sovaldi Olysio?
I am curious if anyone knows why some of the patients taking Sovaldi Olysio failed to acheive SVR?
The Cosmos trial numbers look great 93 or so to 100 percent make it to SVR12 but what about the 7 percent who relapsed?
Just nervous I guess. I have 12 days to go on the 12 week treatment. I'm 3 time null responder GT 1a with cirrhosis and hella hoping it works this time.
Best wishes to all my fellow heppers and their supporters,
Lynn
The Cosmos trial numbers look great 93 or so to 100 percent make it to SVR12 but what about the 7 percent who relapsed?
Just nervous I guess. I have 12 days to go on the 12 week treatment. I'm 3 time null responder GT 1a with cirrhosis and hella hoping it works this time.
Best wishes to all my fellow heppers and their supporters,
Lynn
I will toast to you (minus champagne) many awesome virus free years ahead. You made it and are now in our new group "The Waiting Warriors" and soon to be SVR we did it group. Welcome and cheers.. ..Kim
Congratulations!!! Wishing you an SVR and good health.
Those still in treatment and us waiting, an old WWII phrase comes to mind: 'Praise God and pass the ammunition', in this case our precious Meds.
Those still in treatment and us waiting, an old WWII phrase comes to mind: 'Praise God and pass the ammunition', in this case our precious Meds.
Thats great news. Huge milestone. I mean, each of us has a check list whenever we are faced with things we need to get through. As patients, as people living our daily lives as best we can...I guess we have alot of checklists...but this line item in the HCV checklist is one we all go through at least once after many steps have already been checked to get to this step (if we choose to treat)...Cheers/Congratulations!
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Wow what a great idea! A toast to a long and healthy life!
I am sure I won't be quite that creative but here's to you me and all dragon warriors out there may we win this fight.
Like the singer says "you're gonna hear me roar!"
Lynn
I am sure I won't be quite that creative but here's to you me and all dragon warriors out there may we win this fight.
Like the singer says "you're gonna hear me roar!"
Lynn
I'm done!!
I put my last Sovaldi pill in an elegant martini glass and made a toast - Buh Bye Hep C! Hello SVR! (fingers crossed) Took photos and sent to my friends who have been cheering me on with the message - I think I'll take the last pill of this $ 84,000 treatment. Thanks Kaiser!
A little strange to not have that ritual of taking those pills at the same time every day but I'm getting used to it
I convinced my doc to order a viral load test at 4 weeks too. He agreed that if it made me more comfortable to not have to wait an entire 3 more months, I could have the labs done post 4, 12 and 24 weeks. Everyone in the department seemed super confident of my success so that was encouraging
Looking forward to some renewed energy and I am so grateful that the stars aligned so that I was able to participate in this new regimen
Couldn't have done it without the support and knowledge that I received from this group
Thanks
I put my last Sovaldi pill in an elegant martini glass and made a toast - Buh Bye Hep C! Hello SVR! (fingers crossed) Took photos and sent to my friends who have been cheering me on with the message - I think I'll take the last pill of this $ 84,000 treatment. Thanks Kaiser!
A little strange to not have that ritual of taking those pills at the same time every day but I'm getting used to it
I convinced my doc to order a viral load test at 4 weeks too. He agreed that if it made me more comfortable to not have to wait an entire 3 more months, I could have the labs done post 4, 12 and 24 weeks. Everyone in the department seemed super confident of my success so that was encouraging
Looking forward to some renewed energy and I am so grateful that the stars aligned so that I was able to participate in this new regimen
Couldn't have done it without the support and knowledge that I received from this group
Thanks
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For Sovaldi/Olyio COSMOS trial cohort 1
(Treatment naive and null responders with F0-F2 liver disease)
Factors Predictive of Response to Simeprevir Plus Sofosbuvir:
After excluding patients with nonvirologic failure, subgroup analysis identified factors associated with lower SVR12 rates
* Genotype 1a HCV with Q80K variant present at baseline
* IL28B TT genotype
All 3 patients who relapsed after end of treatment had genotype 1a HCV with Q80K variant at baseline and IL28B TT genotype
Viral kinetics profiles in these patients fell within ranges observed for patients who attained SVR12" (Meaning the RVR makes no different in outcome). Or as the study report states it "After excluding patients with nonvirologic failure, subgroup analysis found no relationship between RVR and SVR12"
(Since F3 or F4 candidates were excluded from the trial we have no data on the difference between SRV rates and cirrhosis vs non-cirrhosis as we do in some of the Solvaldi phase 3 trials).
---------------------------------------------------------------------------------------
COSMOS Cohort 2: 12-24 Weeks of Simeprevir + Sofosbuvir:
Treatment-naive patients and previous null responders with genotype 1 HCV infection and METAVIR F3-F4 fibrosis
The trial only contained 87 patients and so data is limited. Further phase 3 studies will be done to learn more about this treatment is those with advanced liver disease.
In this study no common factors could be found among those who relapsed.
" * Analysis of 3 patients who relapsed after end of treatment (EOT) identified no common factors predictive of relapse
* All patients completed study therapy and had undetectable HCV RNA at EOT period
* Viral kinetics revealed HCV RNA for relapsers decreased to within or below ranges observed for patients who attained SVR12"
Remember we have made tremendous progress in the last few years and treatments have never been more effective and safe. Because of these new breakthroughs in treatment many will be saved from having to advance to cirrhosis and suffer with liver failure or liver cancer and need to have liver transplants to continue living. A great deal has already been accomplished. Unfortunately we aren't at the point were everyone of us can be cure just yet. Hopefully soon very soon. While it is appropriate to be excited about the new options we all have now... Believing that we all have a 90% chance of cure no matter what our genotype or history of liver disease could be very disappointing for the minority that will fail. I believe we all should be hopeful and positive but realistic about our real chances of SRV. Maybe sharing the real SRV data would be more helpful than saying because you are undetectable at week 4 or end of treatment you will be cured for sure because that is just no true no matter how much we would like it to be.
Newer and better treatments will be coming soon so for most people there is always a fall back plan. A chance to retreat with better treatments. For those with advanced cirrhosis and liver cancer there is hope also. We still have liver transplantation which has never had such good outcomes and with the new hep C treatments even us, the hearest of the hard to treat have more hope than ever for curing our hep C post transplant. We won't have only a 30% of cure our hep C post transplant as others did only a few years ago. Yes, we have an excellent chance of being the first group of hep C transplant patients to live as long as others transplanted for other liver diseases for the very first time. Truly a brighter future lies ahead for all of us no matter what out particular medical situation is.
Lynn, I hope this at least stimulated thought about where we have been, where we are now and where we are headed with treatment. And particularly pointing out some of the challenges for us folks who are the more difficult to treat. We have come a very long way already but we just aren't where we want and need to be. Not just yet. Luckily the near future holds great promise for all of us. We just have to hang tough, do what we need to do while accepting where we are today, and knowing and believing that tomorrow while be a better day for all of us.
Hector