You don't need 20 grms af fat for telepravir

[quayle]

Many times I questioned the clinic nurse And the treating Doctor and they both said it just needs to be taken,with a tall gglass full cream milk or a couple of tablespoons of full cream yougurt,so what has antyone else been told they have to strickly take 20gms of fat.a sI was told that is not the case.

[hrsepwrguy]

Effects of Food on Oral Absorption  

The systemic exposure (AUC) to telaprevir was increased by 237% when telaprevir was administered with a standard fat meal (containing 533 kcal and 21 g fat) compared to when telaprevir was administered under fasting conditions. In addition, the type of meal significantly affects exposure to telaprevir. Relative to fasting, when telaprevir was administered with a low-fat meal (249 kcal, 3.6 g fat) and a high-fat meal (928 kcal, 56 g fat), the systemic exposure (AUC) to telaprevir was increased by approximately 117% and 330%, respectively. Doses of INCIVEK were administered within 30 minutes of completing a meal or snack containing approximately 20 grams of fat in the Phase 3 trials. Therefore, INCIVEK should always be taken with food (not low fat)

How should I take INCIVEK?  

Take INCIVEK exactly as your healthcare provider tells you. Your healthcare provider will tell you how much INCIVEK to take and when to take it.  

Take INCIVEK 3 times a day. Each dose should be taken 7 to 9 hours apart.  Eat a meal or snack that contains about 20 grams of fat, within 30 minutes before you take each dose of INCIVEK. Talk to your healthcare provider about examples of foods that you can eat that contain about 20 grams of fat. Always take INCIVEK with food.

http://pi.vrtx.com/files/uspi_telaprevir.pdf

The info above is straight out of the incivek/telaprevir prescribing information sheet, maybe you should show that to the docs

[uncledudeness]

I'm on week 10 and my NP was insistent that i take the 20 grams of fat and to space it out every 8 hours. i'm sure i am not consuming all 20 grams with each pill cuz i just might go postal. i've already punched my stupid smart phone 20 times when the alarm goes off every frikkkkin 8 hours of my life.
when i'm done with the incivek i am gonna fast for a week.

i would also like to find the idiotjerkdopedweabdrooler that came up with the packaging for incivek and shrink wrap him/her in the same wrapper. i also punched the stupid package too. riba rage alert.....

[uncledudeness]

,,,,i meant to say "each dose of incivek" .... not pill.....correction

i think i'm gonna punch the incivek box right now too.....POW that felt better.

[Advocate1955]

My husband received very clear instructions regarding 20 g of fat with each dose of Incivek.  We were told it was crucial in order to assure the best absorption possible of Incivek.
Advocate1955

[Ironpony]

A much as we hate these fats, why question it when it is very clearly stated in the Incivek/prescribing information that hrspwguy provided. There are many new members starting Incivek and it would be a shame for them to read this and think the fats are not needed...when they they are crucial in order to assure the best absorption possible of Incivek. (which I was told just as Advocate was how important it is to take with these PI's)

Aside from absorption, my side effects were bad enough if I went too low on the fats or ate too small of an amount... too little fat = erupting volcano!!! (trying not be too graphic here. :))

[orphanedhawk]

Maybe the milk and cream has a much higher fat content down under ?
Here in North America, everyone is being told to take it with the 20grams of fat
.
hrpwr's reply shows the manufacturer's suggestions. They did the trials and testing, and I'd follow their advice.

[HectorSF]

hrsepwrguy said it all.
"The info above is straight out of the incivek/telaprevir prescribing information sheet, maybe you should show that to the docs."

Doesn't get any self evident and definitive than that!
As we used to say say in the IT world...when in doubt read the manual!

Maybe the doctor should learn how to prescribe Incivek correctly before treating people with it? What else doesn't he/she know about treating with Incivek?

Hector

[Ilove2shop72]

My dr says eat 20 grams of fat before taking and that is what I do. I am into my third week of treatment and doing great.  I am doing triple treatment (Incivek).  I went for 2 wk check up and my blood counts were good and ALT and AST were almost back to normal. Before treatment in the 300's.  I feel great except for extreme anal itching.  OMG. Dr says after 12 weeks are done it will get better. I hope so!  Follow 20 gr of fat rule and you should do great. It is tough but will be so worth it.  Good luck to you.

[copyman]

Like I have posted here many times I took my pills with a glass of "whole" milk.

Not saying it is right for everyone but it worked for me.

[hrsepwrguy]

WHY RISK IT ??????

When the prescribing instructions clearly state take with 20 grams of fat.

You took a risk and got by with it but please stop encouraging people to not follow prescribing information, it is reckless and irresponsible

[can-do-man]

In the trial I was in one person become SVR with only a few weeks of treatment..... So should that person be telling everybody to follow what he did because he got lucky???

Do you really think that one day these researchers just decided to add 20 grams of fat with a meal or a snack??? Maybe they were bored but I kinda doubt it............

[herrokitty]

are you mad?! I almost need more than 20g to not feel the sides as much. also, why pay $20,000 for pills that are absorbed into your body with fat, and not take it as prescribed by the manufacturer?

[Idyllic]

Have you have treated before?  Ideally your treatment decisions are based on a combination of the level of confidence you have in your doctor, independent research & the prescription information - err...and maybe comparing notes with others.

I encourage you to learn the facts and the study data before you make deviate from them.  According to the link below the PIs were only just approved in Australia. I would ask how many patients your doctor has treated with Telaprevir and what he is basing his assumptions on.

https://www.mja.com.au/journal/2012/196/10/changing-therapeutic-landscape-hepatitis-c

I am not trying to freak you out or anything since there is no way we can know everything walking into treatment.  As time goes by you are going to want the peace of mind this is all going to work and knowing you did everything you could to clear the virus.

Best of luck to you

[charlie2247]

Try avacado, trail mix, peanutbutter and Ritz crakers Just get in to munching. A little medical M will help

[uncledudeness]

i couldn't agree with Hrsepwrguy any more. i too think it is irresponsible to mislead members of this forum when it clearly states that 20 grams of fat is the prescribed dosage. i don't understand why someone would intentionally disregard the recommendations when it comes to such an important requirement.

i truly hope that no one reads this thread and thinks that taking incivek with a glass of milk is the way to go...........................IT IS NOT....

[flcyclist]

The prescribing information is based on years of research through clinical trials done by highly qualified doctors.  If your treatment team is able to present you data or studies to validate their claims, then please post them to allow us to learn.  Otherwise, this sound like very poor advice coming from an ill informed doctor that could potentially compromise your (and others) end result in tx.  

You have to ask yourself, is this a risk you're willing to take and wonder if tx fails, could it be due to not following the prescribing protocol?  If so, good luck.  And if your doctor provides any information to support his advice, please post an update.

[BoceprevirGal]

  "Many times I questioned the clinic nurse And the treating Doctor and they both said.."~  the thing about your statement is this:   Your Doctor and your Nurse arent the ones trying to rid themselves of this nasty, and sneaky virus. If you didn't achieve SVR (aka, you're cured) because you didnt eat the 20 calories of fat, to aid with absorption of Incivek, then these two people who gave this (faulty) advice, wouldn't be the ones who's life has been affected (for the worse) by this mis-imfo.
   Whole cream milk IS a good way to get fat calories though, and most likely two large glasses of cream (Half-and Half) or Heavy Cream would be 20 grams of fat, you just have to measure it, good luck :)

[frijole]

If you haven't started and this is such a big issue, choose Victrelis instead.  There are no high fat requirements.  You must eat something, but just a snack and it doesn't have to be high fat --- but then you might change your b----h to the fact that you have to take it for the duration of the treatment, just not 12 weeks.  

How can you choose not to have a 237% advantage?

[BoceprevirGal]

  Okay, I googled, and an 8 ounce cup of milk almost has 8 grams of fat in it, so it would be 3 8 oz cups of whole milk, or 3 of those very small containers of whole milk, it's very "doable".
  I Treated with the Victrelis, but increased my fat uptake a bit anyhow, and I did gain 10 lbs during my Treatment, but I had very little nausea, because the food in my stomach rly seemed to help. I was a peanut-butter fan also, the nice oily stuff...you can do it!

[hrsepwrguy]

"Therefore, INCIVEK should always be taken with FOOD"

"Always take INCIVEK with FOOD. "

http://pi.vrtx.com/files/uspi_telaprevir.pdf

5.3 Food Effect To achieve optimal exposure, telaprevir should be taken with FOOD.

http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AntiviralDrugsAdvisoryCommittee/UCM252562

[can-do-man]

Maybe Keith is not being clear enough here folks..... FOOD, FOOD, FOOD.
Google that, FOOD!!!

[jules2551]

Food is any substance[1] consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism and assimilated by the organism's cells in an effort to produce energy, maintain life, or stimulate growth

[hrsepwrguy]

food  (fuːd)

nourishment in more or less solid form as opposed to liquid form: food and drink

http://dictionary.reference.com/browse/food

milk
 
an opaque white or bluish-white liquid

this liquid as secreted by cows, goats, or certain other animals

any liquid resembling this, as the liquid within a coconut

http://dictionary.reference.com/browse/milk