"Okay, I admit to being a little anal"
Nothing wrong with that girl, if for some reason your not happy with having a little one may i suggest eating alot of fat????.....:)
>I still do 12 laps in the pool daily,
wow! On a good day I sometimes manage 12 'laps' up and down my drive way....
frijole:nice post - made me go back and dig up the "patient information" section for my ribasphere rx : "Take this medicine with food". As with the copegus directions above, no mention of fat.
the main point, nicely summarized by lynda, is not that taking fat won't improve rbv absorption (it will) or that adequate rbv is not a key factor in svr (it is) but that adjusting rbv levels with avocadoes and peanut butter is not the best way to do the job. Given that we are saturated with rbv within a few weeks of tx, AUC rather than Cmax or absorption time from single dose measurement is the relevant stat. (and what's the AUC difference relative to an ordinary meal?).
Strange thing is that though there is unanimous agreement about the importance of rbv, what constitutes an "optimal" rbv dose is still very murky. Serum concentration is hard to measure in the US (though possibly available through trial NCT01097395 at UC Denver) and is still missing reliable comparison points. This leaves weight (at least 13-14 mg/kg) and Hgb decline (at least 3 units of Hgb drop - from rbv, not PI).
Not a very optimal definition of optimal...
As the doctor pointed out on my blood work results visit Tuesday, it's not necessary for 20 grams of fat, and warned me about weight gain. I've been on treatment almost 6 weeks and put on 6 pounds. So let's see, I'm pretty good with math, 48 weeks = 48 lbs.....
No, I can't agree with the 20 grams. I will take my chances with 10 grams, and let's not forget that this fat protocol was mandated to be taken with Ribavirin without Victrelis or Incivek Now that those have been added to patients, is this fat thing necessary? A question that will raise debates, perplex even scientists and especially some patients.
So far in this treatment plan (one month traditional lead-in and 9 days Victrelis), I notice the constant medicinal taste in my mouth. I will add that the doctor has me on Prevacid as I developed acid reflux after adding Victrelis. It’s well under control now..
Surprisingly enough, I still do 12 laps in the pool daily, no lip sores (first week, yes), not ready to strangle anyone, hair not falling out, not losing weight (quite the contrary), good humor. What's right with this picture?
Here's something: The nurse who works for the company that sends my meds is very well aware of patients’ reactions regarding agonies, as well as successes. She pointed out that attitude is everything, and she’s right. In fact after I told her how good I feel under this bombardment, she said “I told you so”.
I for one, never think I’m on treatment. I keep very occupied writing my new screenplay, doing things around the house, working on new songs, etc... and the only time I think about treatment is when the alarm goes off to take the meds. Otherwise, it’s up to you. 48 weeks = 48 lbs....?
Magnum
I am really glad you are doing so well. What was your start date and what was your VL at the end of the lead in and after 4 weeks of VIC (if you are there yet)
Okay, I admit to being a little anal but I have started a spreadsheet of people starting therapy since May. I have missed a lot but it looks like INC - 30, VIC - 8.
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lol..it is good sometimes good to keep score :)
To new folks..frjole"s advice will be invaluable to you going forward ..with her knowledge of HCV and tx.