Aa
Can someone please help
My husband did6months of tx he relapsed at week 23 we just went to UVA and the doctor said he will look for a trial but the new treatment for geno 1 is not approved for geno 3 which he has. He suggested milt thistle what is the best one there are so many.What else could he do while he waiters His liver biopsy is stage 2 that was 3 years ago getting ready to have another done in march.Any suggestions????? Please help. Thank you...
Hello,my husband isnt treating now.I asked the Doctor if there were any supplements he could take while he waited on a trial and the doctor suggested Milk Thistle.
Hi he was doing tx. Und at week 2 at week 23 the viral load shot back up to 3million.
Perhap, I was mistaken and it's St. John's Wort that you should not take
when treating with Incivik. I told you someone smarter than me would answer
your question. I'm glad I was corrected.
Seems I better take a closer look at Milk Thistle. If there is controversy regarding using it I better investigate. I don't want to over look somthing that may help, but won't hurt. If there's a possibility of it being beneficial I would sure try some. I told you theses guys were smart.
Back to the top for HELP!
Hang in there,
Reva
when treating with Incivik. I told you someone smarter than me would answer
your question. I'm glad I was corrected.
Seems I better take a closer look at Milk Thistle. If there is controversy regarding using it I better investigate. I don't want to over look somthing that may help, but won't hurt. If there's a possibility of it being beneficial I would sure try some. I told you theses guys were smart.
Back to the top for HELP!
Hang in there,
Reva
Abstract
Silymarin, the active principle of the milk thistle Silybum marianum, protects experimental animals against various hepatotoxic substances. To determine the effect of silymarin on the outcome of patients with cirrhosis, a double blind, prospective, randomized study was performed in 170 patients with cirrhosis. 87 patients (alcoholic 46, non-alcoholic 41; 61 male, 26 female; Child A, 47; B, 37; C, 3; mean age 57) received 140 mg silymarin three times daily. 83 patients (alcoholic 45, non-alcoholic 38; 62 male, 21 female; Child A, 42; B, 32; C, 9: mean age 58) received a placebo. Non-compliant patients and patients who failed to come to a control were considered as 'drop outs' and were withdrawn from the study. All patients received the same treatment until the last patient entered had finished 2-years of treatment. The mean observation period was 41 months. There were 10 drop outs in the placebo group and 14 in the treatment group. In the placebo group, 37 (+2 drop outs) patients had died, and in 31 of these, death was related to liver disease. In the treatment group, 24 (+4 drop outs) had died, and in 18 of these, death was related to liver disease. The 4-year survival rate was 58 +/- 9% (S.E.) in silymarin-treated patients and 39 +/- 9% in the placebo group (P = 0.036). Analysis of subgroups indicated that treatment was effective in patients with alcoholic cirrhosis (P = 0.01) and in patients initially rated 'Child A' (P = 0.03). No side effects of drug treatment were observed.(ABSTRACT TRUNCATED AT 250 WORDS)
Silymarin, the active principle of the milk thistle Silybum marianum, protects experimental animals against various hepatotoxic substances. To determine the effect of silymarin on the outcome of patients with cirrhosis, a double blind, prospective, randomized study was performed in 170 patients with cirrhosis. 87 patients (alcoholic 46, non-alcoholic 41; 61 male, 26 female; Child A, 47; B, 37; C, 3; mean age 57) received 140 mg silymarin three times daily. 83 patients (alcoholic 45, non-alcoholic 38; 62 male, 21 female; Child A, 42; B, 32; C, 9: mean age 58) received a placebo. Non-compliant patients and patients who failed to come to a control were considered as 'drop outs' and were withdrawn from the study. All patients received the same treatment until the last patient entered had finished 2-years of treatment. The mean observation period was 41 months. There were 10 drop outs in the placebo group and 14 in the treatment group. In the placebo group, 37 (+2 drop outs) patients had died, and in 31 of these, death was related to liver disease. In the treatment group, 24 (+4 drop outs) had died, and in 18 of these, death was related to liver disease. The 4-year survival rate was 58 +/- 9% (S.E.) in silymarin-treated patients and 39 +/- 9% in the placebo group (P = 0.036). Analysis of subgroups indicated that treatment was effective in patients with alcoholic cirrhosis (P = 0.01) and in patients initially rated 'Child A' (P = 0.03). No side effects of drug treatment were observed.(ABSTRACT TRUNCATED AT 250 WORDS)
That study was conducted on people with cirrhosis due to alcoholism. It has nothing to do with HCV. Didn't seem to work to well to me 24 people died when treated with Milk Thistle.
Hi, I remembered seeing this post a couple months back and thought you might want to review.
http://www.medhelp.org/posts/Hepatitis-C/AASLD---Milk-Thistle-Has-No-Medical-Benefit-accoring-to-Study/show/1628636
I also remembered seeing this a couple months back and dug it up for you. It talks about a small trial of teleprevir (incivek) with geno 3.
http://hepatitiscnewdrugs.blogspot.com/2011/06/telaprevirincivek-isnt-useful-for-all.html
My doctor told me she had just received a letter confirming there would be an all orals trials starting in march and it sounded like it would be for all genotypes. Anyway, just hearsay and don't know which one, but you may wish to keep your eyes open.
http://www.medhelp.org/posts/Hepatitis-C/AASLD---Milk-Thistle-Has-No-Medical-Benefit-accoring-to-Study/show/1628636
I also remembered seeing this a couple months back and dug it up for you. It talks about a small trial of teleprevir (incivek) with geno 3.
http://hepatitiscnewdrugs.blogspot.com/2011/06/telaprevirincivek-isnt-useful-for-all.html
My doctor told me she had just received a letter confirming there would be an all orals trials starting in march and it sounded like it would be for all genotypes. Anyway, just hearsay and don't know which one, but you may wish to keep your eyes open.
They are giving MT intravenously to HCV tx non-responders/relapsers at the Uni Klink, Vienna. The prof there is Ferenci. There is a pub med here with his name on it. http://www.ncbi.nlm.nih.gov/pubmed/2671116
Can I please see a clinical study that concluded green tea prohibits the entry of the virus into the liver.
That's correct, the new protease inhibitors (Telaprevir/Incivek and Boceprevir) are only intended for Genotype 1 (the most common and hardest one to treat). I haven't heard of anything new for genotypes 2/3...BUT, 4 million people have HCV in the US alone, and that's a HUGE market, so pharma companies are tripping over themselves to develop new drugs.
I also biopsied at Level 2 three years ago, and just started treatment last week. If your husband takes good care of himself, he could afford to wait a while; either for a more definitive treatment, or to get himself prepped for the next round. I got my viral load from 12M down to 2M with nothing more than:
No alcohol or smoking.
Decent diet, and exercise 2-3 days/week. (lost about 25 pounds)
Milk Thistle; and juicing wheatgrass, carrots and beets daily.
Tapering off most of my other medications (with docs help).
The goal was just to take the load off my liver and pump my immune system up as much as possible.
I don't think it matters where you get the Milk Thistle, as long as it's organic and not made in China. I just get it at Trader Joe's and take two a day.
Seriously, juicing makes a huge difference with your nutrition and energy levels...both critical to a successful treatment. With a few minor lifestyle changes before the next round, your husband has a really good chance of beating it.
And get him on this forum!!! :-)
I also biopsied at Level 2 three years ago, and just started treatment last week. If your husband takes good care of himself, he could afford to wait a while; either for a more definitive treatment, or to get himself prepped for the next round. I got my viral load from 12M down to 2M with nothing more than:
No alcohol or smoking.
Decent diet, and exercise 2-3 days/week. (lost about 25 pounds)
Milk Thistle; and juicing wheatgrass, carrots and beets daily.
Tapering off most of my other medications (with docs help).
The goal was just to take the load off my liver and pump my immune system up as much as possible.
I don't think it matters where you get the Milk Thistle, as long as it's organic and not made in China. I just get it at Trader Joe's and take two a day.
Seriously, juicing makes a huge difference with your nutrition and energy levels...both critical to a successful treatment. With a few minor lifestyle changes before the next round, your husband has a really good chance of beating it.
And get him on this forum!!! :-)
My doctor is OK with Milk Thistle as well; before and during treatment. I have no scientific data to back it up, but I credit Milk Thistle in part with helping to bring my viral loads down from 12M to 2M prior to treatment. That, and a good diet, exercise, no smoking or alcohol.
I'm not saying it's OK to take - everyone needs to make their own choice there - but it seems to have helped me...
I'm not saying it's OK to take - everyone needs to make their own choice there - but it seems to have helped me...
Actually there's some controversy surrounding milk thistle.
My doctors okay with it.
One person I knew who did treatment and relapsed in 2007 was told to keep taking it by her doctor.
She swears it's kept her liver from getting worse.
Its active ingredient silimarin is commonly prescribed for liver ailments outside the US.
My doctors okay with it.
One person I knew who did treatment and relapsed in 2007 was told to keep taking it by her doctor.
She swears it's kept her liver from getting worse.
Its active ingredient silimarin is commonly prescribed for liver ailments outside the US.
So sorry to hear your husband relapsed at week 23. Good luck in finding a new trial.
Are you sure about the Milk Thistle restriction while on Incivek? St. Johns Wort is prohibited, but I've never heard that about Milk Thistle...
He relapsed at 23 weeks? Just curious, so he was UND post tx and then at nearly 6 months he relapsed? When was his first VL post tx? So sorry to hear of this news he must be devastated.
Please double check on if he shoud be taking milk thistle. I've never heard of a doctor making that suggestion. I know for sure you are not to take it when
you're treating with Incivik.
There are members of the Forum who will be better able to comment on trials. My answer will bring you back to the top of forum and some off the really informed members will comment.
Good Luck
you're treating with Incivik.
There are members of the Forum who will be better able to comment on trials. My answer will bring you back to the top of forum and some off the really informed members will comment.
Good Luck
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