Aa
metformin, it can reverse liver disease and IR
I'm having a real dilemna here, and I would really like to see more discussion of this topic.
here is a great synopsis I just found:
http://www.nature.com/nm/journal/v6/n9/full/nm0900_998.html
WOW, that was a mouthful!!
in light of the findings from all those studies listed I would think this needs much closer examination.
In light of the fact that I am currently UND and have no virus, the reversal of fatty liver and less necrosis and less HCC all sounds very appealing, not to mention any reduction in IR would mean ones own Interferon response would be better post tx. and this alone may increase ones chances of an SVR even if begun at the end of an SOC regime.
Perhaps now, more than any other time it could help insure one will recognize any lingering HCV and seek and destroy as designed.
As long as one kept the dose low, monitored the liver, and watched for lactic acidosis, what would be the harm in trying?
arguments in favor or opposed please weigh in, if obese women went from 20% to 60% SVR that should tell us something??
mb
here is a great synopsis I just found:
http://www.nature.com/nm/journal/v6/n9/full/nm0900_998.html
WOW, that was a mouthful!!
in light of the findings from all those studies listed I would think this needs much closer examination.
In light of the fact that I am currently UND and have no virus, the reversal of fatty liver and less necrosis and less HCC all sounds very appealing, not to mention any reduction in IR would mean ones own Interferon response would be better post tx. and this alone may increase ones chances of an SVR even if begun at the end of an SOC regime.
Perhaps now, more than any other time it could help insure one will recognize any lingering HCV and seek and destroy as designed.
As long as one kept the dose low, monitored the liver, and watched for lactic acidosis, what would be the harm in trying?
arguments in favor or opposed please weigh in, if obese women went from 20% to 60% SVR that should tell us something??
mb
JP: . I am as guilty as the next one of playing doctor on the internet, so any time I can listen to someone with credentials, I like to do that.... I've been around a long time and I still tend to ask my doc if a particular study is valid. It has sure shown me what I don't know.
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We tend to think alike. While this place is an excellent resource, I personally used it as a starting place for my treatment decisions and not as an ending place.
After seeing something here of interest, I would then do my best to further my knowledge through other studies and websites. Then, armed with a tentative plan, I would run it by my treatment doctor -- or at two very important junctures of treatment, I ran my hypothesis by three or more liver specialists.
In doing so, sometimes my plan was confirmed, sometimes it was criticized and sometimes I was left about as clear (or confused) as when I started :)
But what I did learn is that there is nothing like running something by a good liver specialist with a large clinical practice who has your entire chart in front of you. That's not to say that I always agreed, but I always weighted their opinion very heavily and would have felt very insecure with some of my treatment decisions had I not done this very important step.
-- Jim
-------------
We tend to think alike. While this place is an excellent resource, I personally used it as a starting place for my treatment decisions and not as an ending place.
After seeing something here of interest, I would then do my best to further my knowledge through other studies and websites. Then, armed with a tentative plan, I would run it by my treatment doctor -- or at two very important junctures of treatment, I ran my hypothesis by three or more liver specialists.
In doing so, sometimes my plan was confirmed, sometimes it was criticized and sometimes I was left about as clear (or confused) as when I started :)
But what I did learn is that there is nothing like running something by a good liver specialist with a large clinical practice who has your entire chart in front of you. That's not to say that I always agreed, but I always weighted their opinion very heavily and would have felt very insecure with some of my treatment decisions had I not done this very important step.
-- Jim
"Sorry to hear you have to contend with all of this, but as Bill pointed out and proved, you can still be successful in treatment if you are determined as he was."
_________________________________________________________________________
I'm not sure what you mean by the above statement as you don't know how much treatment I have done. I am running neck in neck with Miles and Susan 400. Very few have been more determined than I. So I kinda sorta resent your statement. It's like blaming the victim.
Co....I realize bread is 15 grams. I am so new at this counting carbs bit I am getting my measurements all mixed up. I am allowed between 135 - 150 grams of carbs a day. In other words 9-10 servings at 15 grams per serving.
Sorry for the confusion.
_________________________________________________________________________
I'm not sure what you mean by the above statement as you don't know how much treatment I have done. I am running neck in neck with Miles and Susan 400. Very few have been more determined than I. So I kinda sorta resent your statement. It's like blaming the victim.
Co....I realize bread is 15 grams. I am so new at this counting carbs bit I am getting my measurements all mixed up. I am allowed between 135 - 150 grams of carbs a day. In other words 9-10 servings at 15 grams per serving.
Sorry for the confusion.
"Update - in response to questions, it appears that metformin may well cross into the brain, presumably at least partly by some sort of active transport. There's some evidence both ways, but it's certainly possible that relevant levels make it in. With any luck, this will be found not to translate to humans, or not with any real clinical effect"
http://pipeline.corante.com/archives/2009/02/26/does_glucophage_make_alzheimers_worse.php
So far none of the studies were done on humans.
Co
One more thing, he is thin for his height. 155 lbs. 6'1" but the A1c hangs around 6.2
which is very good.
which is very good.
Just of claify the hypoglycemia my husband experiences. He takes glipizide/metformin 5/500 4 x day plus metoprolol, warfarin and digoxin which will lower blood sugar too so I was incorrect in saying the metformin soley causes the drop in blood sugar. He probably shouldn't be taking the glipizide/metormin with all those other drugs from what I've read so may have to look into this.
Trinity
Trinity
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