Aa
sofusbuvir ledipasvir regarding my viral loads question opinions appreciated
Hi I am on the sofosbuvir / ledispasvir trial
Start of treatment I had a 3 million viral Load Alt 180 Ast 120
Week 1 467 000
Week 2 264000 Alt 53 Ast 38
Should I be worried that my week 2 result is not undetected or closer to undetected .?
I am concerned as I have cirrhosis and have failed telapprevir interferon ribavirin .
Any opinions would be very much appreciated .
Start of treatment I had a 3 million viral Load Alt 180 Ast 120
Week 1 467 000
Week 2 264000 Alt 53 Ast 38
Should I be worried that my week 2 result is not undetected or closer to undetected .?
I am concerned as I have cirrhosis and have failed telapprevir interferon ribavirin .
Any opinions would be very much appreciated .
I am taking sofosbuvir/ledispasvir single pill alone for 12 weeks .
As I have advanced scarring I think my chances from what I read are about 80 % at least I hope they are that high .
I feel good especially the second week , into my third and forth week have had some pains in my liver area they come and go not sure what that is but they disappeared today .
The second week felt like I had been walking around with weights tied to my legs for years which I believed felt normal and all of sudden someone took those weights of my legs and my energy was much better and less aches and pains .
As I have advanced scarring I think my chances from what I read are about 80 % at least I hope they are that high .
I feel good especially the second week , into my third and forth week have had some pains in my liver area they come and go not sure what that is but they disappeared today .
The second week felt like I had been walking around with weights tied to my legs for years which I believed felt normal and all of sudden someone took those weights of my legs and my energy was much better and less aches and pains .
Just to clarify...theres one clinical trial in the U.S. (ID # NCTO1805882) which is using the 3-in-1 combo in a single pill to tx gt1a. There arev several trials using the dual combo FDC (aka, GS 7977/GS 5885; i.e. sofosbuvir/ledipasvir) alone, and several trials using FDC and Vedroprivir (aka GS9451) as 2 seperate pills taken together. The 3-in-1 single pill clinical trial is near Washington DC. If this is not the trial in which your enrolled , and the drug your taking is merely the FDC dual combo in one without the Vedroprivir kicker, than according to the Synergy and Electron studies, the odds of acheiving SVR12 for gt1a's are less, and for gt1a cirrhotics considerably less. This is why Vedroprivir is being added to the "cocktail". Dont despair, the FDC combo is better than any other tx currently available, it just doesnt have the 99-100% cure rate the 3-in-1 has. Than again, the 3-in-1 tends to tax the liver quite heavily.
Id appreciate very much if youd keep this forum posted with updates on your tx, particularly the numbers of your next lab result. That pill your taking has a third indgredient in case your not aware. Its either GS-9451 or the sister direct-acting antiviral protease inhibitor (Gileads silver-bullet). Yea, the odds were against gt1a's with the Sov-Olys combo because approx 50% of all gt1a's carried the Q80 polymorph gene which blocked the effects of Olysio (contrary to popular belief that Sovaldi negated this block). The relapse rates belabored the obvious. Be it as it may, you carry the torch of hope at this time and we're all watching close. Any question you have can probably be answered better in this forum than by most research scientists. (Not to suggest abandoning the professionals all together). Im just wary of late, wondering how much research goes toward actually finding a cure and how much is diverted to boost stock margin.
I am genotype 1a which I think is hardest to treat . I need to think positive I will soon find out .
Hi and welcome. Wow! I think your results so far are outstanding and its evident your headed in the right direction. In 2 short weeks your liver enzymes are already down 75% which indicates the meds are doing their job.
Good Luck with this exciting new Tx, and keep us posted as the weeks progress.
Be well
....Kim
Good Luck with this exciting new Tx, and keep us posted as the weeks progress.
Be well
....Kim
"Should I be worried that my week 2 result is not undetected or closer to undetected .? "
No. This is not old peg-interferon based treatment when some people responded to treatment and others didn't. All people respond and become undetectable on Sovaldi treatments and stay undetectable for as long as they are treating. People only fail this treatment by relapsing after stopping treatment. What happens on treatment does not determine if you will relapse or not. It is the factors such as cirrhosis in your case that most effect your chances of SVR.
There hasn't been shown any correlation between when a person becomes undetectable on Sovaldi based treatment and SVR.
"am concerned as I have cirrhosis and have failed telapprevir interferon ribavirin . "
Being concerned is understandable because cirrhotics always have lesser SVR rates than those with lesser stages of liver disease and they do with this treatment. Unfortunately your cirrhosis can't be changed. But many cirrhotics have been cured with this treatment so I think it is best to think positively.
Having cirrhosis and treating in hopes of getting cure is a good idea as you cirrhosis may still be able to reverse itself and SVR also lessens the risk of liver cancer in those with cirrhosis.
Your liver enzymes will come down as the virus does indicating less inflammation caused by the virus as it replicates and injures the liver.
Good luck with your treatment.
Hector
No. This is not old peg-interferon based treatment when some people responded to treatment and others didn't. All people respond and become undetectable on Sovaldi treatments and stay undetectable for as long as they are treating. People only fail this treatment by relapsing after stopping treatment. What happens on treatment does not determine if you will relapse or not. It is the factors such as cirrhosis in your case that most effect your chances of SVR.
There hasn't been shown any correlation between when a person becomes undetectable on Sovaldi based treatment and SVR.
"am concerned as I have cirrhosis and have failed telapprevir interferon ribavirin . "
Being concerned is understandable because cirrhotics always have lesser SVR rates than those with lesser stages of liver disease and they do with this treatment. Unfortunately your cirrhosis can't be changed. But many cirrhotics have been cured with this treatment so I think it is best to think positively.
Having cirrhosis and treating in hopes of getting cure is a good idea as you cirrhosis may still be able to reverse itself and SVR also lessens the risk of liver cancer in those with cirrhosis.
Your liver enzymes will come down as the virus does indicating less inflammation caused by the virus as it replicates and injures the liver.
Good luck with your treatment.
Hector
My hep doc said everyone taking sofosbuvir becomes UND by approx week 4. With these new drugs, it's all about relapse.
Welcome to the Hep C Community.
Most people are undetected at week 4 and some take longer. Once you go undetected you will remain undetected for the rest of the treatment. You seem on track to be UND by week 4. I wouldn't worry given the improvements you are seeing already.
What is your Genotype? I know there are many who will be interested in how you respond to this treatment. Please do keep us posted as you move forward on treatment.
Wishing you SVR in the near future. You are one of the lucky ones to already have access to this combo pill.
Nan
Most people are undetected at week 4 and some take longer. Once you go undetected you will remain undetected for the rest of the treatment. You seem on track to be UND by week 4. I wouldn't worry given the improvements you are seeing already.
What is your Genotype? I know there are many who will be interested in how you respond to this treatment. Please do keep us posted as you move forward on treatment.
Wishing you SVR in the near future. You are one of the lucky ones to already have access to this combo pill.
Nan
yes these are better I am just disappointed after 2 weeks I still have a viral load of 264 000 , hopefully will be undetected by week 4 if not , don't know what will happen but I do know it would completely devastate me if I am taken off this trial .
With these new meds log drops really have no meaning. Under treatment with Telaprevir you would not have even had close to a one log drop. Being und at week four would be great but even then its not a game changer. Congrats on your liver tests, which are pretty much in the normal range... Best to you.
my alts and ast have no been in this normal range for about 20 years so I am hoping week 3 result will be much better
It's my understanding that week four is when you should be undetected. Even still, this has still been a significant drop. I will be watching your progress, because I also failed Telaprevir (relapse). I'm a gt 1a several failings prior to that too. I don't have cirrhosis, but I have everything else going against me in terms of Il28b and gt etc. I'm really hoping S + L is all that. Best wishes for SVR!!
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