twenty-two days

[bluemetal]

Has anyone discontinued tx on sovalldi-olysio before completing the 84 days? Im a Gt 1a  F-4 cirrhotic. Had no prior tx until now. Started the S-O combo on 7/16/14. Terminated tx 8/6/14, twenty-two days later due to rare but serious side effect. Not from the drug combo per se but probably due to some other unrecognized medical condition. (Currently being looked into). Blood work is due 8/11/14 to detrmine whether the 22 days had any impact on the virus. Must now place entire hope on isolating cause for terminating tx and wait for that miracle drug coming in Oct.

[QWC]

Yeah--I won't let them put anything with Ribaviron or interferon near me--I know it would either kill me or turn me suicidal--after I saw what it did to him,  (at least 5-6 years ago), I would even summarize that it is more poisonous than the chemo and radiation I traumatically had to watch kill my Mom in the 90's.  Q

[QWC]

Thank You, Bluemetal.  It seems like there is finally some good news.  Do you now if there is any comparison with this new news to that other treatment that won't be approved for a couple months (forgive my spelling---I think it is called something like Daviduclir--some D word?? that is also supposed to work for the 1a's?)
Did I tell you I also found out I have GT 2 as well as 1a and think my treatment might need to be more complicated...I cannot even Find ANYONE in both communities I am in who has this "very rare" Multiple Genotypes case--I've been searching and really cannot find any info on it.  ...Q

[dontworry_behappy1]

Welcome to the forum.  

[Sarah1949]

I'm glad to hear this because I was just approved for Sovaldi but denied for Olysio pending a Q80K test, and so was thinking if I can't get the Olysio should I go with the Ribavirin. And now, I definitely think I'll refuse the Riba and wait for October 10. Unless, I get the Olysio.

My mother also had a terrible time with Interferon back in the 90's and her experience was enough to make me swear I'd never do Interferon.

[bluemetal]

Cirrhosis is a catch-22 of supreme evil design. We are becomming a colony of vampires, damned in whatever we try, and damned if we dont try. A catch-22 by definition: a situation in which a desired solution to a problem is impossible to attain because of inherently illogical rules or conditions in the problem itself.  Ex:a cirrhotic liver cannot properly or adequately absorb and process vitamins A, D, K, with D being thee most difficult. Yet D is required for life and any attempt to attain the required dose leadfs to dire consequences (i.e. portal hypertension, etc) We learn this the hard way when stepping into direct sunlight (deadly to vampires). UV radiation carries mega doses of D and will even penetrate regular clothing. A few minutes in the summer sun can cause symptoms ranging from very rapid heartbeat (portal hyper) to anemic-like weakness, sunburn, etc. Many cirrhotics reverse sleep patterns, not out of morbid fear of the sun but simply because of physiological changes induced by the damaged liver. We become creatures of the night. The only solution to this unsolvable problem , while wearing full bright white hooded cloaks and sunglasses, is to clear the virus or prepare for transplant. On a more enlightening note--this just hit the news for those who havent heard: Aug 15, 2014, Achillion Pharmaceuticals (www.achillion.com). Phase 2 Proxy study. Sovaldi/ACH-3102 combo. 100% SVR4 with 8 weeks tx.  Gt1a with HCV RNA baseline vof 7.22 log. No on-tx viral breakthrough or post-tx relapse 12 weeks SVR. At last it looks like they found the "achilles heel" of this virusl Achillion is now on par with Gilead. By years end the war of all viral warswill be in full rage with the cure at our doorstep. Theres hope yet fellow vamps!

[QWC]

My best advice to you blue, is to wait --- please don't rush into another treatment until they have stuff for us 1a's figured out--it might seem like forever, but I say this because I have a cousin who was on treatment 3 times (got it through a blood transfusion), and he asked his doc, "if I keep going on treatment and relapsing, won't it make the virus stronger?"  His doc unfortunately said, "Yes".  Be patient and take good care of ourselves by eating lots of fruits and vegss, I even take a lot of carefully researched herbs that are good for the liver.  And I try, (but it is so hard) to lay off the sugar.  I notice my liver hurts when I eat sugar.  Thinking of you, Q