weight based????

[santaclaus]

hi all, just a quick question. i took my 2nd shot las nite and still no sides or any probs 2 worry bout,
im 3a and on 180 peg and 800 riba, i weigh 90.8kg and my hb was 16.2 on thursday.
i jus want 2 know how do i go about getting doc 2 up my riba?
i mentioned it 2 the nurse b4 i seen the doc on thurs and she started talking bout a weight based injection????
its jus that i really want 2 beat it this time around and i feel if i can handle it would be 2 up my riba.

please all ur thoughts are needed.

wayne

[santaclaus]

i think wat ur taking is ok as long as u can handle it, im tryin 2 push 4 1200 - 1400 as 800 is not enough 4 me. as u can see everything seems ok and my hb is high

[Marcia2202]

You weigh 59kg. That means that you are getting almost 17mg/kg which is a nice dose. With 800mg, you would be getting 13.5mg/kg. I would say it is better to get a little bit more than less, if you are able to take it and if your doctors allow it.

I would have liked to have 1000mg, but my doctor didn't agree. I weigh 56kg. Maybe I would have cleared by 4 weeks, if I had gotten it.

At least, if you will ever have to have a dosage reduction, it will be reduced to the 'normal' dose. It's seems good to me to have a buffer like that!

Good luck with treatment.

God bless,

Marcia

[LindaC1207]

Odd, my weight is around 130 lbs and I'm taking 1000 mgs a day of Ribaviran.  Now if someone who weighs 140 lbs only takes 800 mgs a day, aren't I taking too much?  Just curious, it doesn't seem to be affecting me in negative way, YET, who's to say what will happen down the road a ways, just want to make sure I'm on the right amount, even though more is probably better, correct?

Linda

[santaclaus]

before tx  8/9/08                                         wk 1 23/9/08
hb  16.4                                                    16.2
pcv .453                                                    .444
rbc 5.22                                                     5.12
mcv 86.7                                                    86.8
mch 31.4                                                   31.6
hpo .1                                                        .1
wbc 11.19 h                                               7.59
platelets 258                                              246
neutrophils 6.32                                         3.76
lymphocyte 3.44                                        2.44
monocytes .65                                          .58
eosinophils .40                                          .43 h  
basophils .10                                             .08

[Marcia2202]

great info...

Do you know what age they are referring to as younger and older? What was the heading of the report/study/article. If you can't remember, I'll try find the it on CCO.

marcia

[frijole]

A couple of other ribavirn factoids from Clinical Care Options --

weight based ribavirin is 13.3mg/kg @ day
high dosed weight based ribavirin is 15.2mg/kg @ day

Also this interesting fact:

"Some studies indicate that ribavirin dose maintenance is particularly important in older patients, such that younger patients are more likely to achieve sustained virologic response (SVR) if ribavirin dosage is decreased later in therapy, whereas older patients are less likely to achieve SVR if ribavirin is reduced or discontinued

In hepatitis C virus (HCV) genotype 1 infection, individuals of younger age may be able to reduce ribavirin dosage after 24 weeks for severe adverse effects without significantly affecting their likelihood of SVR, whereas doing so in older patients may result in a reduced chance of SVR"