Boceprevir Trial failed

[Keith_2008]

Just to let some of you know that I have been on the Boceprevir trial for 5 months and I did not clear the virus. I quit as a result of the fact I was unable to get to undetectable limits in a time frame that I thought would achieve SVR. My last blood test came up at around 60 VL with only a 30 point drop from the month before. So it just goes to show you that no matter what you take. This ain't no wonder drug but I still think it helps more people than it hurts. I suffered headaches, Muscle aches, coughing from the interferon, fatigue and rashes just to name a few side effects. My doctor says I will have to wait until 2011 to try and treatment again.

[Keith_2008]

Thanks to all that posted. I think it helps to keep us periodically up to date with certain study's so we know if they are working or not. Also it helps others to understand what to expect from their treatment and how many people are having success or not.

[StormRider]

Hi Keith,

Sorry to hear that you didn't reach UND, I probably would have done the same as you and try another day if I didn't reach UND after five months. I am also participating in the BOC trial for naives. Friday I started my 24th week, started the same day as "sweet lips". I also had RVR and reached UND at week six. This entire ordeal has not been easy and can't wait until it comes to an end, I'm hoping to stop at week 28. All the best to you!

[Rockerforlife]

I am starting to notice that my leg muscles get fatigued and the bottoms of my feet hurt if i stand for a long time...i went for a bike ride today and i sure felt my legs...im surprised  i made it this far with losing it....and i was workn 50 hour weeks at my last job....12 more shot and i will find out if im done

[fretboard]

Yes there was a couple of us who had to drop off early.  I was down to 188, I think that's how low I was in my 5th week after only taking the boceprevir for 3 or 4 days but I was never UND.  I had a couple of health issues going on and the jerk at work just pushed me into throwing in the towel.

I had a bx in 11/08 with zero fibrosis and grade 2, right before I started the trial.  One of the biggest problems I ran into was depression which I plan to revisit at a later date.  Also, I am almost always anemic so I hope to change that thru exercise and eating better.  Unfortunately I am always in pain due to a back injury and with the HepC my back just kills me so of course I plan on trying tx again once I can get my health up to par.  thx cando

[can-do-man]

Also greatbird seems to be responding well to boceprevir and had cleared early.

[can-do-man]

I'm 2 weeks behind rocker, I am a geno 1 who also has cirrhosis, so i'm one of the hardest to tx. My first tx i was a slow responder under soc. Treated a total of 86 weeks and relapsed. This time with boceprevir i am a RVR.

Fretboard who post here was also a RVR with boceprevir but do to personal reasons had to stop tx. (i think do to work issues).

There was also another responder that had to end tx early, don't recall her name.

Bill1028 is the only one i recall that was forced to stop but he was getting the placebo and will be put in the provide study and given the real drug

To me thats sounds like a petty good track record

Wishing you the best going forward and understand your decision to end it sense if you were only getting soc as a late responder you would have needed to extend tx to have a better chance for svr. But these trials don't allow this.