Boceprevir Trial failed

[Keith_2008]

Just to let some of you know that I have been on the Boceprevir trial for 5 months and I did not clear the virus. I quit as a result of the fact I was unable to get to undetectable limits in a time frame that I thought would achieve SVR. My last blood test came up at around 60 VL with only a 30 point drop from the month before. So it just goes to show you that no matter what you take. This ain't no wonder drug but I still think it helps more people than it hurts. I suffered headaches, Muscle aches, coughing from the interferon, fatigue and rashes just to name a few side effects. My doctor says I will have to wait until 2011 to try and treatment again.

[smaug48]

Sorry to hear that you didn't clear.  At least you will get another shot at taking that dragon down.  Hope you start feeling better soon.

smaug

[can-do-man]

Sorry to hear, i'm in the relapser trial with boceprevir, if your in the tx naive trial what are you comparing your sx effects to? My first tx was just SOC and i really don't see much difference in my sides with the boceprevir. Most everybody has sx effects from tx.

While this trial i'm in is also double blinded its pretty clear i'm getting the real thing as i was und 2 weeks after starting the boceprevir. Your tx sounds like my first tx with just soc as i just did go und by 24 weeks.

With your Doctors comment about waiting till 2011 to tx again it sounds like he thinks you were also getting the placebo sense thats when these new drugs should hit the market and IF you were getting the real thing you wouldn't be able to tx again with these pi's. At least at this time.

Hang in there and best to you.

Cando

[GreatBird]

I am in the boceprevir trial. Just did shot #18. I'm tx naive. Did go UND between weeks 9 and 10. I don't know what arm I'm in either--but I do know I'm getting the drug.

I've had sx from the peg, the riba, and the boceprevir. Not always easy to tell, but that aftertaste from the boceprevir is unmistakeable. Did you have that too?

So sorry it did not work out for you!

[Keith_2008]

The drug company does not really tell you what arm you are in otherwise it would not be a blind study. So I can't answer that question. I was in the 3rd phase of the trial. I believe that I was actually getting the Boceprevir and not the placebo. I did seem to have some minor side effects with the Boceprevir that leads me to believe that is what I was getting. If I was on Placebo I would feel no difference in side effects right?

They do not pull people from the study at week 12. The drug company will keep you in until week 24 and if you undetectable they will keep treating you and if you are detectable they will stop treatment if you are getting the Boceprevir and will begin treatment with Boceprevir if you were getting the Placebo.

If my memory serves me correctly I think you were in this study and quit after just a couple of weeks of treatment. Is that correct?

[GreatBird]

Which version of the trial are you on? I was under the impression that they would pull people at 12 weeks if they were not UND.

Are you sure you had the boceprevir and not the placebo? In the trial I'm on (tx naive phase 3) they do not unblind until 28 weeks. I think.