Aa
Boceprevir Trial failed
Just to let some of you know that I have been on the Boceprevir trial for 5 months and I did not clear the virus. I quit as a result of the fact I was unable to get to undetectable limits in a time frame that I thought would achieve SVR. My last blood test came up at around 60 VL with only a 30 point drop from the month before. So it just goes to show you that no matter what you take. This ain't no wonder drug but I still think it helps more people than it hurts. I suffered headaches, Muscle aches, coughing from the interferon, fatigue and rashes just to name a few side effects. My doctor says I will have to wait until 2011 to try and treatment again.
I'm not sure how many people here have had successful treatment with Boceprevir but it would be interesting to know. Right now I know that there were about 4 of us that started treatment around the same time and Rockerforlife is the only one who has had some success with it. If there are others out there who have had successful treatment with Boceprevir I would like to hear from you.
I am not really sure I was ever getting the Boceprevir. I originally thought I was but can't be certain anymore and toward the end of treatment I felt like maybe I really never was getting the Boceprevir. The doctors seem to think I was not getting the Boceprevir.
Another question is when a drug company share's their data for success rate of 74% does that include the people like myself who drop out or just the people who stayed in for treatment and failed. It seems to me if you did not include the people who dropped out that the data would not be accurate as most people who drop out of the study is because they failed to reach undetectable levels of viral loads within a certain time frame that would achieve SRV levels. It would change the success rate quite dramatically if that were the case and with the knowledge I have now it seems to me that the success rate stated is higher than it actually is and that may be due to the way the data is collected.
I am not really sure I was ever getting the Boceprevir. I originally thought I was but can't be certain anymore and toward the end of treatment I felt like maybe I really never was getting the Boceprevir. The doctors seem to think I was not getting the Boceprevir.
Another question is when a drug company share's their data for success rate of 74% does that include the people like myself who drop out or just the people who stayed in for treatment and failed. It seems to me if you did not include the people who dropped out that the data would not be accurate as most people who drop out of the study is because they failed to reach undetectable levels of viral loads within a certain time frame that would achieve SRV levels. It would change the success rate quite dramatically if that were the case and with the knowledge I have now it seems to me that the success rate stated is higher than it actually is and that may be due to the way the data is collected.
IM also so sorry to hear you were pulled out of the trial,as you all know im in the Boceprevir relapser double blinded trial and i cleared 2 weeks after taking the BOC and am still clear today...just did shot 24,i may be stopping at week 36...depending which arm im in.so 12 more shots dont sound too bad....but if im in the other arm.im only at the halfway mark of 48 weks....i know im getiing the real BOC because i cleared so fast...in my previous TX with SOC...i dint clear until after wk 12...ant the taste is pretty strange...i get the taste when i wake up in the mornings...its weird...my tonge and mouth tastes awful bit my lips taste like a sweet taste almost...has anyone experienced the bad taste and the sweet lip thing???
Sorry to hear the trial didn't work out well for you.
I am also in a double blinded trial and I was absolutely sure, no doubt in my mind I was on the real drug based on the sx I had for the first 12 weeks of triple therapy.
Imagine my surprise at the 24 week point when I was told I had to continue for the full 48 weeks. So technically, the only thing we can be sure of is that if they keep us going, we are UND.
Bottom line.....we're blinded. We won't know what we were taking until they unblind us. Hopefully you will be able to get into a rollover if you were in fact on a placebo.
On behalf of future tx'ers...I want to thank you for taking part in this trial =)
I wish you well
Isobella
I am also in a double blinded trial and I was absolutely sure, no doubt in my mind I was on the real drug based on the sx I had for the first 12 weeks of triple therapy.
Imagine my surprise at the 24 week point when I was told I had to continue for the full 48 weeks. So technically, the only thing we can be sure of is that if they keep us going, we are UND.
Bottom line.....we're blinded. We won't know what we were taking until they unblind us. Hopefully you will be able to get into a rollover if you were in fact on a placebo.
On behalf of future tx'ers...I want to thank you for taking part in this trial =)
I wish you well
Isobella
Yes same as the relapser trial, but if one was to quit the trial early would that still stand? I know the relapser trial is totally different then the naive trial and i'm not up on how it works, but in the relapser trial i was told if i would quit early i would not be able to be in the provide study. Its a mute point with me but i do know i had to comply with their rules to get in the rollover if needed........ Hope all is well with you.
cando
cando
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