Hi, I am a 50 yo white female. The last time I had alcohol was one glass of wine nearly 2 years ago, and even before that I only had five or fewer drinks per year. Around 20 years ago I did go through a bout of social drinking, but I was never anything near being an alcoholic. I do not take any OTC drugs except for Zantac 150 - no ibuprofen, acetomeniphen, cold remedies, herbs, vitamins, nothing. At the beginning of July my AST and ALT were normal, and they have been normal all my life. In mid-August my AST was 80 and ALT was 146. Docs thought that was a lab error, so I had it rechecked a month later. Both levels were even higher. I've had it checked weekly since then and they are higher each week. I have had a full battery of liver labs to check for hep A, B, C, autoimmune diseases, numerous liver diseases, all are negative. I am scheduled for a liver bx in 2 weeks but can't get in to see hepatologist for 5 more weeks. If my levels keep rising at this rate, it's hard saying how high they will get by then. I am cutting some RXs to see if this is medication induced, but too soon to tell. Here's my question: How high can the levels go before you are in some kind of serious danger? What can happen if they just keep rising and rising, and at what point are you in dire straits? Many thanks for your input.