Aa
CNS inflammation
Hi,
I have been diagnised with Acute CNS inflamation.
I did MRI which shows multiple rounded ring-enhancing brain lasions. Based on that I did CT scan, which was negative with no evidence for cysticercosis.
I used to have weakness in my left arm and face and now tickling in my left leg. Other than that I do not have problems with vision or moving at least for now.
My CSF was nonreactive. I had an elevated IgG% and index and synthesis rate.
Can somebody explain me what all that means and expecially the last sentance in simple words? Is there any posibility for MS and if so how can I understand and what could I do? What means ADEM?
I know that my questions are simple but I want simple word answer.
Thank you a lot
I have been diagnised with Acute CNS inflamation.
I did MRI which shows multiple rounded ring-enhancing brain lasions. Based on that I did CT scan, which was negative with no evidence for cysticercosis.
I used to have weakness in my left arm and face and now tickling in my left leg. Other than that I do not have problems with vision or moving at least for now.
My CSF was nonreactive. I had an elevated IgG% and index and synthesis rate.
Can somebody explain me what all that means and expecially the last sentance in simple words? Is there any posibility for MS and if so how can I understand and what could I do? What means ADEM?
I know that my questions are simple but I want simple word answer.
Thank you a lot
I am having exactly the same symptoms - I am so afraid it is MS - I am awaiting results of the lumbar puncture but have acute inflamation of the brain and total numbness and pins and needles down my left side - I can still move and walk with no problem - it is only sensory - can anyone give me some advice please?
new to this forum - only joined today as I need to chat to others with the same symptoms.
new to this forum - only joined today as I need to chat to others with the same symptoms.
I am having exactly the same symptoms - I am so afraid it is MS - I am awaiting results of the lumbar puncture but have acute inflamation of the brain and total numbness and pins and needles down my left side - I can still move and walk with no problem - it is only sensory - can anyone give me some advice please?
hi,
ADEM stands for acute disseminated encephalomyelitis. it means that you are having an inflammation of the brain and its covering (the "myelin"). if you have an elevated IgG, it means that you are producing antibodies to the virus causing the inflammation. elevated IgG index and synthesis rate means you are producing more IgG than normal in response to the virus.
hope this helps
ADEM stands for acute disseminated encephalomyelitis. it means that you are having an inflammation of the brain and its covering (the "myelin"). if you have an elevated IgG, it means that you are producing antibodies to the virus causing the inflammation. elevated IgG index and synthesis rate means you are producing more IgG than normal in response to the virus.
hope this helps
Hello Dear,
Increased levels of CSF IgG can be due to excess production of IgG within the central nervous system (multiple sclerosis and several other diseases) or it can be due to leakage of plasma proteins into the CSF (inflammation or trauma). To discriminate between these two possibilities, the IgG index is calculated from IgG and albumin measurements performed in CSF and serum. The calculation usually takes the following form:
IgG index = [IgG (CSF) / IgG (serum)] / [Albumin (CSF) /Albumin (serum)]
An elevated IgG index, which indicates increased production of IgG within the central nervous system, is found in about 90% of MS cases
Refer http://www.labtestsonline.org/understanding/conditions/multiplesclerosis-2.html
Acute disseminated encephalomyelitis (ADEM) is an acute inflammatory disease of the central nervous system and may follow systemic viral infections (post infectious encephalomyelitis), vaccination (post vaccinial encephalomyelitis), or occur spontaneously. Although there is no universal definition of ADEM, most reports have described young adults or children with an acute onset of focal or multi focal neurological symptoms and signs variably associated with a meningo-encephalitic syndrome.
There are no generally accepted diagnostic criteria for ADEM; thus, distinguishing ADEM from the first episode of MS is often difficult
Refer http://www.annalsofian.org/article.asp?issn=0972-2327;year=2006;volume=9;issue=1;spage=20;epage=24;aulast=Maramattom
Best
Increased levels of CSF IgG can be due to excess production of IgG within the central nervous system (multiple sclerosis and several other diseases) or it can be due to leakage of plasma proteins into the CSF (inflammation or trauma). To discriminate between these two possibilities, the IgG index is calculated from IgG and albumin measurements performed in CSF and serum. The calculation usually takes the following form:
IgG index = [IgG (CSF) / IgG (serum)] / [Albumin (CSF) /Albumin (serum)]
An elevated IgG index, which indicates increased production of IgG within the central nervous system, is found in about 90% of MS cases
Refer http://www.labtestsonline.org/understanding/conditions/multiplesclerosis-2.html
Acute disseminated encephalomyelitis (ADEM) is an acute inflammatory disease of the central nervous system and may follow systemic viral infections (post infectious encephalomyelitis), vaccination (post vaccinial encephalomyelitis), or occur spontaneously. Although there is no universal definition of ADEM, most reports have described young adults or children with an acute onset of focal or multi focal neurological symptoms and signs variably associated with a meningo-encephalitic syndrome.
There are no generally accepted diagnostic criteria for ADEM; thus, distinguishing ADEM from the first episode of MS is often difficult
Refer http://www.annalsofian.org/article.asp?issn=0972-2327;year=2006;volume=9;issue=1;spage=20;epage=24;aulast=Maramattom
Best
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