I have been on Topamax for 2 years,The first year and half I was fine but suddenly according to doctor lost weight.I think she needs to look deeper on weight loos cause I only take 50 mg at bedtime and 50 morning.So not a large dose. I think she needs to make sure none my tumors have turned to Cancer I have neurofibromatosis 1 and in my family it turns to cancer.