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Nerve pain medications

Anyone have luck with other pain medications other than Percoset for nerve pain?
10 Responses
1855076 tn?1337118903
Gabapentin and Lyrica are often used for nerve pain.  Less commonly Clonidine, an old blood pressure med, is used.  Also some antidepressants like Cymbalta and Nortryptiline are used in treating nerve pain.  Nerve pain can be very difficult to treat.  My doctor tried me on many combinations and dosages of medications before we found what works best for me.

Where is your nerve pain and what have you tried to treat it?
547368 tn?1440545385
Hello and Welcome!

Marycarmel has offered you some good suggestions. She's right on, as usual. I've tried several of nerve pain medications.

Percocet (Oxycodone) is not considered a medication to treat nerve pain. It does not target the Nerve Fibers. It can be effective in treating pain in general. Frankly it isn't as effective for me as other opiates. You may want to consider a change in opiate. I know it's one of the stronger short acting opiates - but we all metabolize medications a bit differently. It's just a thought.

In years past I have been on Cymbalta, Amitriptyline, Gabapentin and a few others I have forgotten. None of those were effective and some of them brought me serious side effects. You can imagine my hesitation when a PMP suggested Lyrica -  I said No!  But there comes a time that you will try anything to relieve the pain.

Lyrica (Pregabalin) first appeared on the U.S. market in fall 2005. In June 2007, the FDA approved Lyrica as a treatment for Fibromyalgia. It was initially used/designed for seizure disorders - but like many medications physicians began using it off-label for other conditions. It is now widely used to treat  (nerve) pain. It is the only medication that controls my neuropathic pain.

All medications, including Aspirin - come with side effects. One of Lyrica's side effects is weight gain. Yup - I've gained 17lbs in a year. I'm currently attempting to reduce my weight - but I'll take those pounds to have relief from the nerve pain. It's been an awesome addition to my pain relieving regime. It's also pricey as there are no Generics - yet.

I've told you a bit about my journey to find Neuropathic Pain relief in hopes that it will give you some guidance and encouragement. You may have to try several of the meds that we have discussed - but don't give up. There is a medication that will reduce your Neuropathic Pain. You may be fortunate and the first one will be effective.

If you have additional questions - or I didn't address your concerns please let me know. I wish you the best and hope to hear from you soon.

Take Care,

Avatar universal
Hi Nervepainj.  :)

First, I'd like to add my Welcome with Tuck's and Mary camel's to our PM (Pain Management) Forum here on the MH (MedHelp) Community.

As Tuck said, marycamel was, as always, correct on with some of the meds that might be able to help you with your neuropathy.  Tuck definitely can tell you about all of the different neuropathy medications out there as she, like many others on MH, has been battling problems with neuropathy for numerous years.  I remember how excited she was when she discovered a medicine that worked for her nerve pain, Lyrica.  She had relief for the first time in what seemed like years.  But, as she told you it is expensive and can cause weight gain.  The most important thing to remember, as Tuck and marycamel pointed out, is that not every medication works for everybody and so you and your Doctor will need to experiment and see which one's work the best for you.  Also, as Tuck pointed out, your Percocet is not for nerve pain, it's for other pain, as you've discovered it hasn't done much to help you with your neuropathy. There's a big difference.  As in most cases when people have more than one type of pain, such as arthritis, DDD (Degenerative Disc Disease), etc. your Doctor will add the Gabapentin, Lyrica, etc. as an additional medication so that both types of pain are being addressed.

I hope you will keep us updated on how you are doing and which of the many neuropathy medications worked for you.  

Best wishes and I look forward to your updates.               ..........           Sherry  :)
Avatar universal
I have Post Herpetic neuralgia after having Shingles my pain didn't go away. I tried Lyrica and Gabapenpentin with horrible side effects also tried amitriplyn and am on  Celexa for depression. I use lidocaine cream and sometimes baclofin but Percoset has been the only thing to take the fire like pain away. Problem is I think  it's not working as well as it used to 10 mg 3 times daily. Is it the generic version that is the problem should I ask for name brand? Also I heard that switching around the opiates might Guelph like take Demerol one week then back to Percoset so my body doesn't build up a tolerance to one or the other. Is that a thing? Is my dosage on par or to little? Why has my pain gotten worse what should I do?
547368 tn?1440545385
I'm sorry to hear that no other medications have been effective in relieving your neuropathic pain. I am glad to hear that at least the Oxycodone has some pain relieving properties for you.

I know you said that you had side effects with Gabapentin - which may preclude you from trying a newer drug, Horizant. It depends on what your side effects were - and how extreme.

Horizant (gabapentin enacarbil) has been approved to treat postherpetic neuralgia (PHN) in adults. You may want to discuss this with your physician.

Back to your question. I don't think there's any doses that are "on par" - especially in this opiate-phobic climate. I'd speculate to say that you are on an average dose of a short acting opiate for chronic pain. There are other choices.

You may benefit from a long acting opiate in addition to the short acting one. I would also think that your physician wouldn't be opposed to increasing you from three to four tablets a day. That's still in-line with what's often being prescribed to many PM patients.

You are certainly
547368 tn?1440545385
Sorry - I must have hit "Post A Comment" by error.

As I was saying you are certainly not at the top wrung of opiate usage by any means.

Demerol is being prescribed less and less these days. I read (some time ago) that research has determined that it was not a effective pain reliever but more of a mood changer - or something close to that. Years back it was the Gold Standard following surgery and in ER rooms. On my last hospitalization I had to insist on Demerol instead of Morphine (I don't react well to Morphine.) so it is still available.

You never get something you don't ask for - that's true in life and Pain Management.

What I believe is important - talk to your prescribing physician. Tell him/her what you have shared with us. You deserve better pain control and I am hopeful that your physician will agree with you - and me. :0)

Good luck our friend in pain. Please keep in touch and let us know how this turns out for you.


Avatar universal
I'm so sorry that you are having so many problems with your meds.  You're not alone as there are my members that have found the different medications just aren't compatible to their systems.  

Kas Tuck said, you could ask for the long-acting medicine to go along with your short-acting med or you could ask for a 4th Percocet to help with your uncontrolled pain.  

I, too, am on Oxycodone (Percocet) and I doubt that the generic (which I take ,also) makes any difference.  They normally are equal in their pain relief.  However, everyone's body reacts differently so you could discuss this with your Doctor.  You must be prepared to pay for it yourself as MOST insurance companies will not pay for  a name brand (Percocet) when there is a generic abailable.  It's extremely expensive so weigh it carefully and check out everything if you decide to give it a try.

I hope you are able to get your pain under control soon.  I'll be looking for your updates.      .............         Sherry    :)
547368 tn?1440545385
I meant to add some info on   for our members that may not have heard of it.

Postherpetic neuralgia (PHN)  is a complication of shingles, which is caused by the chickenpox (herpes zoster) virus. PHN affects nerve fibers and skin, causing burning pain that lasts long after the rash and blisters of shingles disappear.

The risk of PHN increases with age, primarily affecting people older than 60. There's no cure, but treatments can ease symptoms. For most people, postherpetic neuralgia improves over time.

PHN is a painful syndrome that can lead to disability in some people. It occurs after an outbreak of herpes zoster, more commonly known as shingles.

Researchers say about 1 million people in the U.S. develop shingles each year. Of these, about 10% will go on to develop PHN.

PHN causes pain in the area affected by shingles, often in the torso, and can last for months or even years after the initial infection.

Thanks for bringing this nasty condition to the attention of our members. I'm sure many have heard of Shingles but how many know about PHN. Please all - get your Shingles Vaccination. It may prevent Shingles which will avoid the possibility of developing PHN.  

My Best,
Avatar universal
I have a lot of nerve pain and the only thing that helps me is Neurontin. It's used for nerve pain
547368 tn?1440545385
Thank you Msme for your input. I'm sorry you too have neuropathic pain. Many of us can relate.

In case some of our members don't know, Neurontin is the brand name for  Gabapentin that was mentioned in several responses. It' can be very effective for some ppl.
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