Explain it as a hormonal disorder, a mismatch between your body structure and its chemistry Your body is structurally unprepared to handle the chemicals (hormones) that it produces, and this causes a wide range of problems. For someone who's already testosterone-dominant, an equivalent disorder would involve reducing testosterone production and increasing estrogen production in his body. This would cause all sorts of symptoms, emotional and physical, that would have similar effects on his mood and behavior.