Got my MD to lower my levo from 112mcg to 75 (titered over 6 months) History- started levo at 50mcg 10 years ago, slowly upped as TSH climbed, MD kept it at under 1. Blood pressure kept climbing, no other reason. I convinced her to try lowering. It worked, but I gained 20 pounds (no other change in diet etc.) And my total T3 has always been at or just below range, so I've got 5mcg T3, taking once a day at 1pm (I eat twice a day, 9 am and around 4-5 pm, take the levo at bedtime, 10pm) I already wake up at night to pee (I'm almost 67) I cannot set al alarm to wake up in the middle of the night to take a 2nd dose (I work full time, I get up before 6am) QUESTION: Anyone else have a good result with once daily T3 added to T4? thanks