Aa
TPO
thank you very much, so basically i will have thyroid failure eventually since im only 21. Can they remove the thyroid since its gonna happen? will that help me feel better? im willing to do anything at this point.
It means it is high enough to do significant damage.
When the count goes above 1,000, Endo's may warn you about the risk if Hashimoto's Encephalopathy, although it is EXCEEDINGLY rare. But my Endo did discuss it with me. There are only a handful of documented cases, but I mention it because 1,000 seems to be some sort of benchmark.
What it really means in practical terms is that you have a high enough count that the antibodies will cause thyroiditis, and it will damage your gland (more quickly than if your count was 500), and that you will have problems staying on one med dosage for five or ten years at a time.
My TPOab was almost the same as your's the last time I had it measured, somewhere around 1,250. I don't know what it is now. Probably lower now that my thyroid is dead.
Many of the members here have a TPOab between 800 and 1,500. Some have posted figures of over 2,000 or 3,000. Over 3,500, if my memory is any good.
A lot of people have a count around 1,200. It's not OMG! high, and it is not unusual, but it is not real good news. It means your Hashimoto's experience will not be the mild, controlled, gradual decline that my sister has experienced.
Thyroid peroxidase:
"The TPO gene provides instructions for making an enzyme called thyroid peroxidase. This enzyme plays a central role in the function of the thyroid gland, a butterfly-shaped tissue in the lower neck. Thyroid peroxidase assists the chemical reaction that adds iodine to a protein called thyroglobulin, a critical step in generating thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism).
To function properly, thyroid peroxidase must be located in the cell membrane of certain thyroid cells, called follicular cells. Thyroid peroxidase has several different versions (isoforms), which vary by size and location within the cell. Some versions are inactive because they are not located in the cell membrane."
http://ghr.nlm.nih.gov/gene=tpo
The more antibodies you have killing cells, the faster the thyroid function degrades. The dead cells do two things. They cause infection and more dead cells, and they cause too much hormome to be released into the blood when the dead cells are eliminated. That is called thyroiditis.
When the count goes above 1,000, Endo's may warn you about the risk if Hashimoto's Encephalopathy, although it is EXCEEDINGLY rare. But my Endo did discuss it with me. There are only a handful of documented cases, but I mention it because 1,000 seems to be some sort of benchmark.
What it really means in practical terms is that you have a high enough count that the antibodies will cause thyroiditis, and it will damage your gland (more quickly than if your count was 500), and that you will have problems staying on one med dosage for five or ten years at a time.
My TPOab was almost the same as your's the last time I had it measured, somewhere around 1,250. I don't know what it is now. Probably lower now that my thyroid is dead.
Many of the members here have a TPOab between 800 and 1,500. Some have posted figures of over 2,000 or 3,000. Over 3,500, if my memory is any good.
A lot of people have a count around 1,200. It's not OMG! high, and it is not unusual, but it is not real good news. It means your Hashimoto's experience will not be the mild, controlled, gradual decline that my sister has experienced.
Thyroid peroxidase:
"The TPO gene provides instructions for making an enzyme called thyroid peroxidase. This enzyme plays a central role in the function of the thyroid gland, a butterfly-shaped tissue in the lower neck. Thyroid peroxidase assists the chemical reaction that adds iodine to a protein called thyroglobulin, a critical step in generating thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism).
To function properly, thyroid peroxidase must be located in the cell membrane of certain thyroid cells, called follicular cells. Thyroid peroxidase has several different versions (isoforms), which vary by size and location within the cell. Some versions are inactive because they are not located in the cell membrane."
http://ghr.nlm.nih.gov/gene=tpo
The more antibodies you have killing cells, the faster the thyroid function degrades. The dead cells do two things. They cause infection and more dead cells, and they cause too much hormome to be released into the blood when the dead cells are eliminated. That is called thyroiditis.
Have an Answer?
You are reading content posted in the Thyroid Disorders Community
We tapped the CDC for information on what you need to know about radiation exposure
Endocrinologist Mark Lupo, MD, answers 10 questions about thyroid disorders and how to treat them
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
