Hi there you must have had somthing else going on in your live to want to try somthing else when you were so well on the prozac, dont stop the meds till you have spoken to your doc but if it was me and I felt well on one drug I would stay put.
good luck janis.
antibiotics can cause derealization. but so can prozac. give it time and see.
Realize that most of these anti-depressants take 4 weeks (or more!) to achieve the desired affect, and things GET WORSE before they get better when taking these A/Ds. It is up to you and your doctor if you want to or need to stop the medication, but you may be stopping it before it even starts working.
It can be very difficult to find a medication that works. Prozac worked very well for you in the past so you may want to take that into consideration. Maybe see if your dr. can prescribe you a few lorazepam or alprozelam to be taken AS NEEDED for any extra anxiety as you adjust to the Prozac.