that is enlarged. None of them are painful. Could the enlargement be due to this new antibiotic being introduced to fight the infection that my body is used to fighting? I need to know if this is something I need to schedule an appointment for.
Yes, it *could* be simply due to your treatment; swollen lymph nodes (sometimes severe) are a possible side effect of Bactrim, albeit one of the rarer ones. However, swollen lymph nodes is such a blanket symptom that it is equally as likely to be caused by something unrelated to your treatment.
If you are taking your medication exactly as prescribed and begin to experience any other symptoms at all, (though particularly fever, any kind of joint pain, abdominal pain or discomfort, dizziness or diarrhea), and if your current symptoms don't fade within a day or two (such quick regression would likely be indicative of an allergic reaction to something unrelated to your treatment), you should schedule an appointment immediately.
In any case--and as with any unfamiliar developments which occur during a course of treatment--it's definitely something you should tell your doctor about at the very least.