Chronic hepatitis B

[asiafem722]

65 y.o. female, found positive for Hepatitis B in 1998. Her first LFT shown
AST (41/41), ALT 36/45. ordered by my primary care MD:

HB E Antibody POSITIVE, HB E Antigen negative, HB SAg (surface antigen) POSITIVE, HB Surface Antibody Negative
Hep A negative, Hep C negative

In Oct 11, 2000 under care of GI/hepatologist, LFT gave:
AST 399/36, ALT 583/39.
In Nov 06, 2000
HBV DNA Quantitative gave  HBV DNA 24200 copies/mL
HBV DNA (pg/mL)  0.085 pg/mL
Lamuvidine was mentioned but not started due to the fact that HBV DNA viral load less than 50000-100000 copies/mL

In Jan 12, 2001, LFT gave:
AST 26/36, ALT 21/39

In Dec 12, 2002 LFT gave:
AST 50/31, ALT 81/30.
US liver, all other test (EGD, Colonoscopy, MRI) normal.

In Jan 10, 2003
AST 32/30, ALT 34/30

In Jan 25, 2006
HBV DNA viral load 719 copies/mL
In Feb 09 2006
HBV DNA 3770 copies/mL
alpha-fetoprotein 6.7 IU/mL (limit 0-15 IU/mL)
In 2007: US liver, other tests: NORMAL

Recently  In June  07 2010 LFT gave:
AST 31/49
ALT 28/55
Alpha-fetoprotein 2.3 ng (limit 0-8.3) by Roche Eclia method
In June 22 2010, labs gave:
HBV Real-time PCR Quant :  HBV 7650 IU/mL
HBV DNA 44500 copies/mL (1 IU= 5.82 copies)
G.I specialist wants to put on VIREAD 300 mg once daily.
Ultra sound liver on June 29 2010 is normal
Hepatitis C and A negative


Since HBV DNA viral load is 44,500 copies which is still under the limitation to treat (< 50,000-100,000 copies/mL).
Should she hold and have another vival load count in December before making decision?

[Jojo997]

why did your friend who attained hbsag negative and hbsab positive went back to hbsab negative, did he/she stopped taking the piles before 6 months?

[stef2011]

can you be then receive vaccination?

if hbsab is present vaccine is useless since you already have the antibodies, it might be useful if you make hbsag negative but no hbsab antibodies

[Jojo997]

One more thing please,
After been declared hbsag negative
can you be then receive vaccination?

Thank you

[Jojo997]

Thank you
I will definitely get back to you
when I start the medication.

Stay blessed

[stef2011]

yes hbsab will make hbsag negative within 6 months, there are very rare mutants but they are very rare and ntz is active on all mutants

[Jojo997]

Thanks so much for the response.
You have been of immense help to me.
God bless you.

If I understand you well, it means this
medicine can total eradicate Hepatitis B
at this stage of my. If I may know, when I
get hbsab antibody means I'm cured from
hepatitis b.