Chronic hepatitis B

[asiafem722]

65 y.o. female, found positive for Hepatitis B in 1998. Her first LFT shown
AST (41/41), ALT 36/45. ordered by my primary care MD:

HB E Antibody POSITIVE, HB E Antigen negative, HB SAg (surface antigen) POSITIVE, HB Surface Antibody Negative
Hep A negative, Hep C negative

In Oct 11, 2000 under care of GI/hepatologist, LFT gave:
AST 399/36, ALT 583/39.
In Nov 06, 2000
HBV DNA Quantitative gave  HBV DNA 24200 copies/mL
HBV DNA (pg/mL)  0.085 pg/mL
Lamuvidine was mentioned but not started due to the fact that HBV DNA viral load less than 50000-100000 copies/mL

In Jan 12, 2001, LFT gave:
AST 26/36, ALT 21/39

In Dec 12, 2002 LFT gave:
AST 50/31, ALT 81/30.
US liver, all other test (EGD, Colonoscopy, MRI) normal.

In Jan 10, 2003
AST 32/30, ALT 34/30

In Jan 25, 2006
HBV DNA viral load 719 copies/mL
In Feb 09 2006
HBV DNA 3770 copies/mL
alpha-fetoprotein 6.7 IU/mL (limit 0-15 IU/mL)
In 2007: US liver, other tests: NORMAL

Recently  In June  07 2010 LFT gave:
AST 31/49
ALT 28/55
Alpha-fetoprotein 2.3 ng (limit 0-8.3) by Roche Eclia method
In June 22 2010, labs gave:
HBV Real-time PCR Quant :  HBV 7650 IU/mL
HBV DNA 44500 copies/mL (1 IU= 5.82 copies)
G.I specialist wants to put on VIREAD 300 mg once daily.
Ultra sound liver on June 29 2010 is normal
Hepatitis C and A negative


Since HBV DNA viral load is 44,500 copies which is still under the limitation to treat (< 50,000-100,000 copies/mL).
Should she hold and have another vival load count in December before making decision?

[stef2011]

please do not miss to update the community on ntz result if you choose to use it

[stef2011]

i am surprised you have hbsag quantification in ghana while US, canada and UK don t, their healthcare systems for hbv look like the worst in the world...

[stef2011]

do not waste time on bee things, try to get generic nizonide500 and you might add vitamin d 5000iu daily, vitamin d is an immune modulator that might help ntz

check vit d (25OH) levels after 3-4months, the optimum level is 50-60ng/ml and maximum level 100ng/ml.
in case you have a history of kidneys stones or kidneys illness check also creatinine and calcium because vit D might increase calcium absorption over normal levels and too much calcium damages kidneys, this is almost impossible with only 500iu daily but better check anyway

[stef2011]

you are slowly clearing the virus and totally inactive, ntz might clear hbsag in a very short time at 1,5 or 2g dose
a member of our group with hbsag 800iu/ml made hbsab antibody in the first month, if you try nitazoxanide use the high dose 1.5g or 2g and let us know if you make hbsab antibody in a couple of months

[Jojo997]

One more thing, a doctor prescribed Forever Bee Pollen for which I have started taking, upon research I found out that, it takes care of so many ailment, it boost the immune system to fight against infectious disease like Hep b. You know importing Alinia from US to Ghana-Africa is very costly unless you have someone who can other in bulk quantities. I heard of Milk Thistle is that too easily available?

Thanks so much. Waiting for your response

[Jojo997]

Thanks so much for the quick response.
Yes, the numbers 591iu/ml.

I thought I could even get one here in Ghana.
Am I active or inactive carrier, also am I infectious

Thank so much