My Clinical Trial (TDF vs. TAF) Post Medication Resutls

[luckyman316]

Wanted to see if anyone can offer any advice. Before I started this, I did not have all these results. My viral load started a 276,000 when I first learned of Hep B, spiked up to 5 million, 12 million and now this (and last result actually was 23 million but I do not have those results in front of me).

Is this an active Chronic infection? Any chance to tell how long I've had this? Or are there any tests to determine how long I've had it?

CBC Results:
WBC - 7.0
RBC - 4,79
Hemoglobin - 14.8
Hematocrit - 45.1
MCV - 94
MCH - 30.9
MCHC - 32.8
RDW - 13.8
Platelets - 254
Neutrophils - 56
Lymphs - 32
Monoctyes - 9
Eos - 3
Basos - 0
Neutrophils (absolute) - 3.9
Lymphs (Absolute) - 2.3
Monocytes (Absolute) - 0.6
Eos (Absolute) - 0.2
Baso (Absolute) - 0.0
Immature Granulocytes - 0
Immature Grans (Abs) - 0

Comp. Metabolic Panel
Glucose - 83
BUN - 20
Creatinine, Serum - 1.16
eGFR If NonAfrican Am - 81
eGFR if African Am - 93
BUN/Creatinine Ratio - 17
Sodium, Serum - 142
Pottasium, Serum - 4.1
Chloride, Serum - 103
Carbon Dioxide, Total - 24
Calcium, Serum - 9.6
Protein, Total Serum - 6.6
Albumin, Serum - 4.3
Globulin, Total - 2.3
A/G Ratio - 1.9
Bilirubin, Total - 0.5
Alkaline Phosphatase, S - 71
AST (SGOT) - 61
ALT (SGPT) - 115

Urinanalysis Gross Exam
Specific Gravity 1.027
pH - 6.0
Urine-Color - Yellow
Appearance - Clear
WBC Esterase - Negative
Protein - Negative
Glucose - Negative
Ketones - Negative
Occult Blood - Negative
Bilirubin - Negative
Urobilinongen, Semi-Qn - 0.2
Nitrite , Urine - Negative

HBV Real-Time PCR, Quant
HBV IU/mL - 18,907,000
log10 HBV IU/mL - 7.277
HBV Copies/mL - 110,040,000
log10 HBV Copies/mL 8.042

Panel 083824
HIV 1/0/2 Abs-Index Value <1.00
HIV 1/0/2 Abs, Qual - Non Reactive

HBV Genotype/PreCore
HBV Genotype - HBV Genotype D detected
HBV PreCore Mutation - Basal Core promoter mutation at 1764 was detected. HBV PreCore Mutation 28 was detected.

Prothrombin Time (PT)
INR - 1.1

AFP, Tumor Marker (serial)
AFP, Serum, Tumor Marker - 1.7

TSH - 1.770

PTT, Activated
aPTT - 26

Hep B Surface Ab
Hep B Surface Ab, Qual - Non-Reactive

Mitochondrial (m2) Antibody - 2.8

Vitamin D, 25-Hydroxy - 59.6

HCV Ab w/Rflx to Verification
HCV Ab - 0.1

Phosphorous, Serum - 4.0

Antinuclear Antibodies Direct
ANA Direct - Negative

Ferritin, Serum - 258

HBsAg Screen - Positive Abnormal

Hep Be Ag - Negative
Hep Be Ab - Positive Abnormal
Thyroid Peroxidase (TPO) Ab - 8
Hep B Core Ab, Tot - Positive Abnormal
Hep A Ab, Total - Negative

So yes, happy my vitamin D levels went up from 14. Still feel I could use 20 more points on there. Also need Hep A vaccine. The rest is good, except for the Hep B portion which I need to clear.

[twinboys1girl4me]

I had that too, even though I was only on Virwad for 6 months (but DNA was low when started which confused me).  My doctor said to see UND she has found it's taking longer with how sensitive the testing is getting.  Also, with most trials you will notice they actually consider <29 or <20 UND, .  I know it's frustrating and hopefully others will have better information.  At least you are consistant and it's not going up.  :)

[luckyman316]

That is what I am glad about too, that the viral load is not going up. In 4 months time I'll be switched to TAF only so that will be interesting to see if anything happens.

At the moment, I've been having some flu like symptoms the past week so I suspect I'm having some sort of immune response.

I also mentioned to the doctor about my chapped/cracked lips and the salty taste coming from my gums for a month. She is sending the bottle that I suspect caused the reaction in for investigation. I thought maybe it was a magnesium deficiency of some sort but it's well within range so this as not an issue.

[luckyman316]

Been a while since I posted any results but here it is:

HBV DNA IU/mL: < 29 IU/mL HBV DNA Detected
Total Bili: 0.4mg/dL
Dir Bili :   0.1 mg/dL  
Ind Bili : 0.3 mg/dL  
AST (SGOT) - 33
ALT (SGPT) - 51 (down 8 points)
Creatine - 1.33 mg/dL (A little high)
Uric Acid - 6.7 mg/dL  
Calcium - 9.5 mg/dL  
Phosphorus - 3.7 mg/dL
pH - 5.5  
CK - 164 U/L
Parathyroid Hormone - 49.3 pg/mL (There's that jump back down again!)
HBsAg: Positive

Just some comments. I drank some water before the test because I had a urine sample that needed to be taken and I already went to the bathroom an hour before my tests (I had to go bad!)

My question: Why is HBV DNA not undetectable yet? I'm getting close to 2 years on this and the test does not show HBV DNA Undetectable. Will it EVER show this (even if my HBsAg is positive?)

[needadvicewithhep]

Im on a trial in the UK its the same testing Gilead use for me they explained <29 is the sensitivity they use.  So might even be undetectable but its hard to say.

However Im also entitled to have government testing every 6months  and that goes as low as <10 which.

ive been on the trial about 18months

Are you e antigen negative?

[luckyman316]

Thanks, that is what was explained to me as well.. the sensitivity of the test. The place I go to also offers as low as <10 but since they do the trial with Gilead for me, we go with this. As far as I can recall:

HBsAg - Positive
HBe Ab - Positive
HBe Ag - Negative

[hepbcurepls]

fibroscore is not always accurate. fibroscan and biopsy are gold standards.

[soa923]

Goodluck to you man, my only concern is your fibrosis  you said you are f0 before you start treatment and now you are f2/f3 . I thought you are not suppose to progress while on treatment . Can please raise it with your doctor why the progression from f0 to f2/f3

[twinboys1girl4me]

That is so great!  Did your doctor ever say anything about the <29 iu/ml but detected?  I've only been on Viread since April but mine has been <20 iu/ml detected ever since after month one.  I test again next month (6 month mark) but don't know if I should ever get to read undetected?

[Nmarius]

Good luck!