My Clinical Trial (TDF vs. TAF) Post Medication Resutls

[luckyman316]

Wanted to see if anyone can offer any advice. Before I started this, I did not have all these results. My viral load started a 276,000 when I first learned of Hep B, spiked up to 5 million, 12 million and now this (and last result actually was 23 million but I do not have those results in front of me).

Is this an active Chronic infection? Any chance to tell how long I've had this? Or are there any tests to determine how long I've had it?

CBC Results:
WBC - 7.0
RBC - 4,79
Hemoglobin - 14.8
Hematocrit - 45.1
MCV - 94
MCH - 30.9
MCHC - 32.8
RDW - 13.8
Platelets - 254
Neutrophils - 56
Lymphs - 32
Monoctyes - 9
Eos - 3
Basos - 0
Neutrophils (absolute) - 3.9
Lymphs (Absolute) - 2.3
Monocytes (Absolute) - 0.6
Eos (Absolute) - 0.2
Baso (Absolute) - 0.0
Immature Granulocytes - 0
Immature Grans (Abs) - 0

Comp. Metabolic Panel
Glucose - 83
BUN - 20
Creatinine, Serum - 1.16
eGFR If NonAfrican Am - 81
eGFR if African Am - 93
BUN/Creatinine Ratio - 17
Sodium, Serum - 142
Pottasium, Serum - 4.1
Chloride, Serum - 103
Carbon Dioxide, Total - 24
Calcium, Serum - 9.6
Protein, Total Serum - 6.6
Albumin, Serum - 4.3
Globulin, Total - 2.3
A/G Ratio - 1.9
Bilirubin, Total - 0.5
Alkaline Phosphatase, S - 71
AST (SGOT) - 61
ALT (SGPT) - 115

Urinanalysis Gross Exam
Specific Gravity 1.027
pH - 6.0
Urine-Color - Yellow
Appearance - Clear
WBC Esterase - Negative
Protein - Negative
Glucose - Negative
Ketones - Negative
Occult Blood - Negative
Bilirubin - Negative
Urobilinongen, Semi-Qn - 0.2
Nitrite , Urine - Negative

HBV Real-Time PCR, Quant
HBV IU/mL - 18,907,000
log10 HBV IU/mL - 7.277
HBV Copies/mL - 110,040,000
log10 HBV Copies/mL 8.042

Panel 083824
HIV 1/0/2 Abs-Index Value <1.00
HIV 1/0/2 Abs, Qual - Non Reactive

HBV Genotype/PreCore
HBV Genotype - HBV Genotype D detected
HBV PreCore Mutation - Basal Core promoter mutation at 1764 was detected. HBV PreCore Mutation 28 was detected.

Prothrombin Time (PT)
INR - 1.1

AFP, Tumor Marker (serial)
AFP, Serum, Tumor Marker - 1.7

TSH - 1.770

PTT, Activated
aPTT - 26

Hep B Surface Ab
Hep B Surface Ab, Qual - Non-Reactive

Mitochondrial (m2) Antibody - 2.8

Vitamin D, 25-Hydroxy - 59.6

HCV Ab w/Rflx to Verification
HCV Ab - 0.1

Phosphorous, Serum - 4.0

Antinuclear Antibodies Direct
ANA Direct - Negative

Ferritin, Serum - 258

HBsAg Screen - Positive Abnormal

Hep Be Ag - Negative
Hep Be Ab - Positive Abnormal
Thyroid Peroxidase (TPO) Ab - 8
Hep B Core Ab, Tot - Positive Abnormal
Hep A Ab, Total - Negative

So yes, happy my vitamin D levels went up from 14. Still feel I could use 20 more points on there. Also need Hep A vaccine. The rest is good, except for the Hep B portion which I need to clear.

[luckyman316]

Thank you melcul. Besides some slight ringing in ear, TMJ and neck issues, I feel pretty decent. I think the sensitivity of this lab only brings it to < 29 for HBV. I don't think it will ever say undetected until I one day clear HBsAg (Which was positive in this lab)

Once I'm done the clinical trial, I will ask the doctor to do his lab which is more detailed.

[melcul]

hei there luckyman, i hope you are feeling ok now, what does this mean
HBV DNA IU/mL: < 29 IU/mL HBV DNA Detected  , shouldn't come Not Detected ? or it's just a typo

[luckyman316]

Just got my latest results back, wanted to share:

HBV DNA IU/mL: < 29 IU/mL HBV DNA Detected
HBsAg
Total Bili: 0.5mg/dL
Dir Bili :   0.1 mg/dL  
Ind Bili : 0.4 mg/dL  
AST (SGOT) - 34 (down one point)
ALT (SGPT) - 54 (up one point)
Creatine - 1.20 mg/dL   (Back to normal)
Uric Acid - 7.1 mg/dL  
Calcium - 9.3 mg/dL  
Phosphorus - 3.7 mg/dL
pH - 5.0  
CK - 274 U/L  (this number jumped up a LOT again)
Parathyroid Hormone - 67.3 pg/mL (Can't get this back down)

Anyway, they refilled stuff and sent me on my way. I suspect they are flip flopping between TAF and TDF in these bottles. Some months, that I have taken it, I develop some major "TMJ" issues and things are really messed up. Others, the issue goes away. I did a lot of reading that Tenofovir/Viread has been known to cause this issue and in some cases, patients needed surgery.

Anyway, next appt is a big one again with more numbers, more blood drawn, DEXA scan, etc. I plan to take in a better diet and do more exercise between now and then. I'm going to buy a book called "the liver healing diet" which details step by step some good recipes and such to help me along the way. Who knows, it's worth a shot! :)

[luckyman316]

Royal, thanks. It looks like Dasani water has no calcium in it either... at least it's not listed on there. So I went ahead with that.

[Royal36]

Luckyman316 how about the alpine spring water(crystal geyser) they sell it by the walmart, Safeway or lucky? All they are 0% calcium. Thanks!

[luckyman316]

They report it, but on water bottles I don't recall seeing the content amount. Just report what is in there. So I'd never be able to tell how much