My Clinical Trial (TDF vs. TAF) Post Medication Resutls

[luckyman316]

Wanted to see if anyone can offer any advice. Before I started this, I did not have all these results. My viral load started a 276,000 when I first learned of Hep B, spiked up to 5 million, 12 million and now this (and last result actually was 23 million but I do not have those results in front of me).

Is this an active Chronic infection? Any chance to tell how long I've had this? Or are there any tests to determine how long I've had it?

CBC Results:
WBC - 7.0
RBC - 4,79
Hemoglobin - 14.8
Hematocrit - 45.1
MCV - 94
MCH - 30.9
MCHC - 32.8
RDW - 13.8
Platelets - 254
Neutrophils - 56
Lymphs - 32
Monoctyes - 9
Eos - 3
Basos - 0
Neutrophils (absolute) - 3.9
Lymphs (Absolute) - 2.3
Monocytes (Absolute) - 0.6
Eos (Absolute) - 0.2
Baso (Absolute) - 0.0
Immature Granulocytes - 0
Immature Grans (Abs) - 0

Comp. Metabolic Panel
Glucose - 83
BUN - 20
Creatinine, Serum - 1.16
eGFR If NonAfrican Am - 81
eGFR if African Am - 93
BUN/Creatinine Ratio - 17
Sodium, Serum - 142
Pottasium, Serum - 4.1
Chloride, Serum - 103
Carbon Dioxide, Total - 24
Calcium, Serum - 9.6
Protein, Total Serum - 6.6
Albumin, Serum - 4.3
Globulin, Total - 2.3
A/G Ratio - 1.9
Bilirubin, Total - 0.5
Alkaline Phosphatase, S - 71
AST (SGOT) - 61
ALT (SGPT) - 115

Urinanalysis Gross Exam
Specific Gravity 1.027
pH - 6.0
Urine-Color - Yellow
Appearance - Clear
WBC Esterase - Negative
Protein - Negative
Glucose - Negative
Ketones - Negative
Occult Blood - Negative
Bilirubin - Negative
Urobilinongen, Semi-Qn - 0.2
Nitrite , Urine - Negative

HBV Real-Time PCR, Quant
HBV IU/mL - 18,907,000
log10 HBV IU/mL - 7.277
HBV Copies/mL - 110,040,000
log10 HBV Copies/mL 8.042

Panel 083824
HIV 1/0/2 Abs-Index Value <1.00
HIV 1/0/2 Abs, Qual - Non Reactive

HBV Genotype/PreCore
HBV Genotype - HBV Genotype D detected
HBV PreCore Mutation - Basal Core promoter mutation at 1764 was detected. HBV PreCore Mutation 28 was detected.

Prothrombin Time (PT)
INR - 1.1

AFP, Tumor Marker (serial)
AFP, Serum, Tumor Marker - 1.7

TSH - 1.770

PTT, Activated
aPTT - 26

Hep B Surface Ab
Hep B Surface Ab, Qual - Non-Reactive

Mitochondrial (m2) Antibody - 2.8

Vitamin D, 25-Hydroxy - 59.6

HCV Ab w/Rflx to Verification
HCV Ab - 0.1

Phosphorous, Serum - 4.0

Antinuclear Antibodies Direct
ANA Direct - Negative

Ferritin, Serum - 258

HBsAg Screen - Positive Abnormal

Hep Be Ag - Negative
Hep Be Ab - Positive Abnormal
Thyroid Peroxidase (TPO) Ab - 8
Hep B Core Ab, Tot - Positive Abnormal
Hep A Ab, Total - Negative

So yes, happy my vitamin D levels went up from 14. Still feel I could use 20 more points on there. Also need Hep A vaccine. The rest is good, except for the Hep B portion which I need to clear.

[luckyman316]

Sharing more info from my trial results. I went back for a follow-up to my doctor today, because he was away when they drew my blood last week. To my surprise, they had the results all ready so I wanted to share it:

HBV DNA IU/mL: < 29 IU/mL HBV DNA Detected
Total Bili: 0.2mg/dL
Dir Bili :   <0.1 mg/dL  
Ind Bili : <0.2 mg/dL  
AST (SGOT) - 33 (down one point)
ALT (SGPT) - 59 (up 5 points)
Creatine - 1.21 mg/dL
Uric Acid - 7.0 mg/dL  
Calcium - 9.5 mg/dL  
Phosphorus - 3.7 mg/dL
pH - 5.5  
CK - 136 U/L  (Down a lot and normalized)
Parathyroid Hormone - 45.7 pg/mL (There's that jump back down again!)
Ostase: 18.52 ug/L
Osteocal: 39.33 ng/mL (This is for bone density and is 1 point too high. It used to be higher than this though, so clearly it's gotten better)


Overall, I'm about as happy as I can be but know I have a LONG way to go with this. I did talk to my doctor about the upcoming ARC-520 conference and he was not aware of it and thanked me for the heads up. After doing some research, they are recruiting HBeAg - Positive patients for it. So I would not qualify.

A few things.. my blood pressure was through the rough when I went to draw blood. Something like 173 over 90 which is way too high for me as it's normally a set 120/80 give or take a few points. Came back a few days later to check up just in case, it was normalized. I've been dealing with plenty of stressful situations which did not help the next day. Also, I am happy to report that my cholesterol is also NORMAL. Something you don't see in today's society often in the USA because of our bad eating habits. No complaints there!

Everything else checked out and my doctor was happy to see no toxicity with the medications or even any reported events by me as a side effect. He was also happy to see me with such a positive attitude!

Anyway, 2 more months and I'm back for another round!

[Fresh100]

That's interesting, I just hope they make a similar drug to peg interferon with out the side effects.  

[luckyman316]

I don't know the exact details. That is all he told me. Sorry

[sorte]

Over 5 years of practice he treated only 10 people with interferon ?! Is it because is states nucs are more preferred/lobbed ? What side effects he saw ?

[luckyman316]

Fresh, I don't know. As per my doctor, he recommends I do not try it. Over the course of the past 5 years or so, he's done it on 10 patients. 3 were Genotype D, 2 were Genotype C and 5 were Genotype A. Of the 10 patients, 3 of them were cured and they were all Genotype A. He saw some of the patients report a lot of bad side effects so he would not want to see me do the same thing, especially if it's not a guaranteed cure for me.

[Fresh100]

Hi luckyman i hope your doing good, just wondered if after your clinical trial  would peg interferon help you to get it undetected also now that it's 29 IU/mL HBV ?