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Can cirrhosis be reversed?
I have compensated cirrhosis as a result of long term HCV - I am hopefully about to be enrolled on a trial which could eliminate the virus. If the trial is successful for me then obviously my liver will no longer be under constant attack and I'm wondering if anyone has experience - or even anecdotal evidence - or reversing compensated cirrhosis?
Even going back to 'just' having severe fibrosis would be an improvement. I've had the cirrhosis for nearly 5 years but my liver has deteriorated very little in that time, my bloods have remained stable - if anything some of the key markers have slightly improved. I don't smoke, drink or eat meat and I run 20 to 25 miles a week - this is my own 'drug free' TX. I've done everything I can to stay healthy and I'm hoping to slowly heal my liver if I get SVR - can it be done?
Even going back to 'just' having severe fibrosis would be an improvement. I've had the cirrhosis for nearly 5 years but my liver has deteriorated very little in that time, my bloods have remained stable - if anything some of the key markers have slightly improved. I don't smoke, drink or eat meat and I run 20 to 25 miles a week - this is my own 'drug free' TX. I've done everything I can to stay healthy and I'm hoping to slowly heal my liver if I get SVR - can it be done?
I treated for 6 months and relapsed after EOT. I'm currently starting week 13 of 24 weeks harvoni. My doc tells me that in the real world, the PI's had about a 75% success rate. So far my docs have had no relapses with harvoni, so i'm hopeful it will stay gone this time.
And to Dario- fantastic and good luck.
And to Dario- fantastic and good luck.
Are you saying you relapsed AFTER finishing treatment, 6months of contnual showingSVR?? If so, THAT is discouraging! OR are you saying you were on treatment for 6 months during which time you were testing undetectable, and then as soon as treatment ended, the virus became detectable again?
The liver does indeed regenerate after treatment. There is a dramatic difference in my ultrasound and blood work after being undetectable for 6 months, even though I relapsed. More than 2 years later, my imaging and baseline blood work before starting treatment with Harvoni is still drastically improved from my previous treatment naive results. I compared my complete record pre and post treatment with 3x Incivek to the current pre treatment results and it seems that even given a brief respite the liver can regenerate rapidly. Even my spleen is no longer enlarged, but normal. Platelets are in normal range again. 30 years of damage undone in a few months. Amazing.
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