Hepatitis C Community
The effect of peg/riba and HCV clearance on cerebral metabolism and neu...
About This Community:

This forum is for questions about medical issues and research aspects of Hepatitis C such as, questions about being newly diagnosed, questions about current treatments, information and participation in discussions about research studies and clinical trials related to Hepatitis. If you would like to communicate with other people who have been touched by Hepatitis, please visit our new Hepatitis Social/Living with Hepatitis forum

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

The effect of peg/riba and HCV clearance on cerebral metabolism and neuropsychological performance.

J Hepatol. 2011 Oct 22. [Epub ahead of print]
Effects of Anti-Viral Therapy and HCV Clearance on Cerebral Metabolism and Cognition.
Byrnes V, Miller A, Lowry D, Hill E, Weinstein C, Alsop D, Lenkinski R, Afdhal NH.
Source

Department of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Chronic hepatitis C virus (HCV) infection is associated with altered cerebral metabolism and cognitive dysfunction. We aimed to evaluate the effect of pegylated interferon/ribavirin (PIFN/R) and HCV clearance on cerebral metabolism and neuropsychological performance.
METHODS:

Fifteen non-cirrhotic HCV positive subjects underwent (1)H MR spectroscopy (MRS) before, during, and after treatment with PIFN/R. The metabolites of interest namely, N-acetylaspartate (NAA), choline (Cho), myo-inositol (MI), and the control metabolite creatine (Cr), were acquired from 3 different brain regions; left basal ganglia, left frontal cortex and left dorso-lateral pre-frontal cortex. Coinciding with this, subjects also underwent a battery of neuropsychological tests to evaluate the domains of verbal learning, memory, attention, language, executive functioning and motor skills. Seven HCV positive controls (not receiving anti-viral therapy) underwent MRS and neuropsychological testing at two time points, 12 weeks apart, to examine for variation in cerebral metabolites over time and the practice effect of repeat neuropsychological testing.
RESULTS:

Significant reductions in basal ganglia Cho/Cr (p=0.03) and basal ganglia MI/Cr (p=0.03) were observed in sustained virological responders (SVRs, n=8), but not non-responders/relapsers (NR/R, n=6), indicative of reduced cerebral infection and/or immune activation in those who cleared virus. SVRs demonstrated significant improvements in verbal learning, memory and visuospatial memory. A small but significant improvement in neurocognitive function secondary to the practice effect was seen in both HCV controls and HCV subjects during treatment.
CONCLUSIONS:

HCV eradication has a beneficial effect on cerebral metabolism and selective aspects of neurocognitive function, and is, an important factor when contemplating anti-viral therapy in HCV, especially in those with mild disease.

See:  http://www.ncbi.nlm.nih.gov/pubmed/22027578

Mike
Related Discussions
10 Comments Post a Comment
Blank
223152_tn?1346981971
Mike
All the more reason to treat, eh?  I can use all the cognitvie function I can get!

Hope you are well and not out there shoveling snow this morning.
frijole
Blank
Avatar_m_tn
This may also validate the above post and can offer a far better explanation of the concept;

http://hepatitiscnewdrugs.blogspot.com/2011/09/hepatitis-c-neuropsychiatric-symptoms.html

willy

Blank
1815939_tn?1377995399
Mike:

Thanks for posting that article. Wow! The more I learn about Hep C the more I realize I have been suffering from its ill effects for years even though I never knew I had it  and my liver enzymes were not that elevated (and sometimes normal). It seems just about all of my heath problems over the last few years (systemic vasculitis, muscle and joint aches, fatigue, slight but noticeable to me memory slowing, general malaise, etc.) are most likely due to Hep C doing it dirty work. Had I known earlier, like the early 90s, and had there been treatment then (which there really was not), I would have jumped at the chance to treat earlier in this disease cycle. It seems that every year that has gone by, this virus has been silently chipping away at the health and well being of my entire body and mind, and in addition to the health of my liver.

frijole:

I agree. All the more reason to treat and to treat early before the virus ravages the body and mind.
Blank
1815939_tn?1377995399
Thanks for posting that article. Makes me even more positive my symptoms are from the Hep C virus and, as I said beore, had treatment been available and had I known I had Hep C, I definitely would have treated in the early 90s, before I developed all of these related problems from Hep C.
Blank
1130586_tn?1316269892
Thanks for the informative post Mike ...

Cheers
Blank
1491755_tn?1333204962
Thanks for posting Mike.
Blank
683664_tn?1330969924
It's good to know that someone is studying these things.  Makes me even more glad about my SVR.  Although it has taken a while to recover from the effects of tx, I do feel a cognitive improvement 2 years later.
Blank
179856_tn?1333550962
Dang now what excuse am I going to have left to use?
Blank
Avatar_m_tn
Thanks Mike-
Interesting information.
-Dave
Blank
184420_tn?1326743408
i know right...????? lmfao ...
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis C Community Resources
RSS Expert Activity
469720_tn?1388149949
Blank
Abdominal Aortic Aneurysm-treatable... Blank
Oct 04 by Lee Kirksey, MDBlank
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
Top Hepatitis Answerers
1747881_tn?1358189534
Blank
hrsepwrguy
Greeley, CO
683231_tn?1408489117
Blank
flyinlynn
Auburn, WA
179856_tn?1333550962
Blank
nygirl7
Planet Earth, CT
317787_tn?1373214989
Blank
Dee1956
DC
96938_tn?1189803458
Blank
FlGuy
South, FL
Avatar_m_tn
Blank
can-do-man
IN