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B6 Toxicity

This is more of a comment than a question, but I would welcome info from anyone who has any experience with this situation. I took a prescription called Folcaps (which had 25 mgs of pyridoxine in it) for a year. In February of 06 I began experiencing symptoms which have now been diagnosed as Pyridoxine (b6) Toxicity Induced Neuropathy. I did not get this diagnosis until August 15, after four MRIs, several specialists and balance testing. My b6 blood level was 81 - the maximum safe level in this test was 32. When reading about b6 toxicity one reads about tingling hands and feet and being "wobbly on your feet" and things of that nature. It can be much more than that. Be careful with Vitamin b6. It's not known if the neurological damage is reversible. Some studies show it is, some show it is not. The damage I have suffered extends to my thyroid, my blood pressure has been lowered (to an unsafe level - it was healthy before), my balance has been damaged - I don't know where my right foot is in space, I've had insomnia, my symptoms are too lengthy to list here. The fatigue that I have been experiencing for the past several months has started to lift now that I've stopped taking the medication, but it is still profound...another hallmark symptom of b6 poisoning. This is a serious toxic situation and one that is not understood by the medical community. I am waiting to find out how much of my life I will get back. I am rebuilding my stamina & neuropathways with an optimistic outlook. And getting the word out. MD's don't know about vitamins. Work with nutritionists. Don't go it solo
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I just wanted to jump on here and warn that there was a lot of quackery on this thread around pages 4-5 by 'gerrysmom' and some others about alternative medicine. I wont blame them because that was the hottest information back then but now things are different. I am in a large b6 toxicity group where we have disproven all of this information.

MTHFR... quackery.
CBS... quackery.
OATS test... quackery
Hair testing... quackery
'practicioners'... quackery
cellular malabsorbption... quackery
conversion to p5p.. quackery
pyroluria... quackery

As a general rule of thumb if you see a website with the words 'holistic', 'natural', 'green', 'alternative', etc or it is on a blog or it doesnt link to peer reviewed scientific studies in a reputable medical journal, it isnt reliable.

Also, experimental labs like 'doctors data', 'metamatrix', 'great plains', 23andme, etc are not reliable and the information is heavily misused by fake doctors to sell supplements. I cannot walk into one of these 'doctors' office without having to leave with a basketfull of 10 supplements and 5 more fake tests. All this genetic testing and wierd labs are a scam. The naturopathic doctors are there to make money and are agents of the supplement companies kind of like people think of doctors and pharmaceuticals.

Dont fall for it. If you want to test if you have functional deficiencies of B12, folate, b6, etc, get the MMA and homocysteine tests - these are the gold standard. There is no problem converting to p5p - what you measure in your blood test is p5p, not the other forms. Most likely nobody here should or will ever take any form of b6 ever again for any reason.

Do NOT use OATs or hair tests to determine b6 status. OATs is only a reflection of daily intake and is highly innacurate. Almost all of us who have had OATs had them tell us that we were low. That is because everyone who takes the OATs test sees that they were low, and a lot of other results are very similar to anyone who takes OATs. It is a scam. Hair tests show nothing about what is going on inside the body with vitamins and minerals. Another scam. The plasma B6 (p5p) level is the gold standard for measuring b6 status.

23andme usage - another scam. All this stuff about SNPS is a bunch of psuedoscience. None of these bold assertions about what your SNPs are doing in your body or how to treat it with supplements has been proven with proper science. It isnt even accurate. I got genetic testing from a different company and some SNPs were different. Furthermore, you dont know if this SNP is even expressing, and if it is expressing how it is effecting your body. Take folate for example - there are something like 2000 other folate metabolism genes and not just MTHFR. Your body has been compensating your genetics your entire life. You got through the first +-20 years of your life just fine without any supplements. What changed? You ADDED suplements. You added crap.

If you got toxic by taking massive doses of b6 like 10mg or 200mg+ then there is no problem with b6 being metabolised/used. That is because these massive doses of b6 are never used in anyone to begin with. The body has no use for anything over 2mg of b6 per day. Its not included in your metabolism. The rest is just excreted in the urine, or stored in the tissues. Your problem was that excretion isnt working or the tissues got full. Usually this is precipited by dehydration and medication use, following years of b6 supplement use.

Most of us are damaged by b6 and that is it. p5p damages cells with caustic chemical bonds. p5p in the brain binds to gaba receptors. p5p impairs detoxification. p5p actually binds to the pyridoxal kinase enzyme and slows down its own metabolism. People think b6 is the culprit but its actually p5p.

Now you are saturated with p5p and your job is to detox, and then heal your nerves. Long recoveries, waves, and setbacks are to be expected. If you experience this, it is not a doubt of b6, as has been suggested. It is normal. Detox takes time. Nerves take time to heal - a lot of time. The amount of time you were taking b6 will play a big part. What is going to help you most is hydration, hydration, electrolytes, low or rda b6 diet, and eventually slowly and consistently adding excercise. If you exercise and then have a huge return of symptoms the next day, you are going too fast and need to go even slower.

Im not saying everyone here has b6 toxicity. However, we shouldnt discredit what b6 toxicity can do in those who are actually toxic. These people have a long road ahead of them and giving them doubts and a bunch of woo and supplement sales pitches or especially telling them that they actually have a deficiency isnt helping.

Those who think theyve found some other answer other than b6 toxicity should think really hard about whether they want to re-add b6 back into their diet, or any supplement. Supposedly harmless supplements got us here and the first place and taking more is just rolling the dice again. A rule of thumb supplementation is it should only be done in small amounts to correct deficient blood levels, if foods have failed. If the supplementation is b6, then very regular testing needs to be done. I saw someone here say they added back in the same amount of b6 as when they got toxic. I hope they are monitoring their levels...
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Have small fiber peripheral neuropathy in my feet that is progressing.  Elevated levels of B6 and ferriting with ZERO supplementation.  Heterozygous for the MTHFR C677T variant (one copy) if that makes any difference or not.  How do I get rid of excess B6 when not supplementing???
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Hi, in Oct 2016 I began experiencing weird neurological symptoms...I was 3 weeks postpartum with my third child. After months of testing to rule out MS, cardio issues, autoimmune diseases, etc etc, my second neurologist tested me for nearly everything that could cause small fiber neuropathy and found my B6 level was over 5 times the max of the range (112 on a 2-21 scale). The toxicity was found in Feb 2017. I was taking a prenatal vitamin with 25mg B6 every day for about a year. Ironic thing is I decided to get a high quality, prescription strength prenatal from my OB instead of over the counter (which only has 2-3mg B6). If I only knew...

I stopped the prenatal right away and symptoms have ebbed and flowed since then. Recently, nearly 3 months after stopping my prenatal and 3 weeks after starting my period since pregnancy, I had a major setback. I could barely move and get out of bed for three days. My husband had to take time off work because we have three small kids and I couldn't care for them. I'm seeing a naturopath on Thursday and I'm excited to get some tips on how to detox.

For the women in the group, do your symptoms tend to ebb and flow with your cycle?

My symptoms include light-headedness (feels like I'm walking on a boat), tingling/burning tongue, lower back pain, numbness/tingling/buzzing in feet and legs, numbness on right side of face and chin, blurry vision, insomnia, heart palps, exercise intolerance, and arms and legs ache with the slightest exertion. My symptoms get much worse when I'm tired, hungry and when I've done too much in a given day.
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Yes, my symptoms even six months after stopping the b6 seem to be worst right before my period starts and I usually feel best late in the cycle after ovulation.
Hi ladies-  Curious how you are both feeling now?  @fruity44 and @mooremam24?  Have your B6 toxicity symptoms subsided at all?  I am 2 months out from stopping all B6 and still no improvement of symptoms.  I had my period last week and everything got worse.  Just trying to find hope that this will eventually get better!!!  Thank you.
I am 18 months past stopping all b6 and just had a month and a half of no sympoms. Then I had vein surgery this week and the b6 pain (mostly muscle pain) came back...it's frustrating but there os hope!
Avatar universal
Hi
I am really glad I found this group. I have been having many strange symptoms for the past 7 mo. Neurologist is not convinced it's the b6, which was almost twice the upper limit when tested last November. My symptoms are mostly on the right side. The bottom of my foot is tingly and I get pains in my calf and the sciatic nerve. Also, my right atm feels like there is plastic wrap around it and my is a little stiff. Lately I have had really tight muscles in my upper right back and neck area. I also get palpitations and lightheadedness sometimes. MRIs have ruled out MS....wonderingvif someone experiences symptoms mostly on one side of their body?
Thanks, Klaudia
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My symptoms started on the right side of my body...my right arm, leg and right side of my face went numb. I thought I was having a stroke. Anyway, since then, it traveled to the other side but right side is still more sensitive.
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I am in search of a newly diagnosed condition called B6 Toxicity. Anyone who has experienced this (severe symptoms of nausea, loss of appetite and dizziness on occasion). Please...help.
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My eyelid would twitch when I took a small amount of B6. However, I learned I could tolerate P5P (active B6) with no problem. Then I read an article by Dr. Werbach that explained this. My body was having trouble converting B6 into its active P5P form. The large amount of B6 was taking up the receptor sites for the active form. So, essentially, my cells weren't getting enough of the active B6. This is what was causing the toxicity from the regular B6 supplementation.

I've since learned why my body was not converting B6 into its active form. You need vitamin B2, thyroid, alpha ketoglutaric acid and magnesium for this conversion. In my case, I had aluminum excess and yeast overgrowth. Both were interfering with alpha ketoglutaric acid, and hence were interfering with this conversion. The aluminum interfered with alpha ketoglutaric acid. The yeast overgrowth produced acetaladehyde, which also interfered with alpha ketoglutaric acid.  

Alcohol also lowers acetaldehyde.   Hence, alcohol also gets rid of alpha ketoglutaric acid and can interfere with the conversion of B6 into its active form. I rarely drank alcohol, so this wasn't my problem, but I mention this in case someone else is wondering why they have trouble with B6.
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Took over 100mg pyridoxine and b-complex a day for almost 2 months. At first I started to experience pressure in my nose. Then I started to get tension headaches and tingling in my face, scalp and neck. I see many have experinced tingling in feet and hands, I havent felt any of that. But I got heart palpitations. At the end of the 2 months I took the b-vitamins I got severe dizzyness and the above symptoms, plus i got sexual side effects like low libido, pleasureless orgasms, and low appetite. I have also have fatigue, tired all the time. Does someone else have experienced sexual side effects like genital parasthesia or other symptoms, and how long did it take you to recover? I have been off of b6 for about 3 weeks and many symptoms have lessened. The symptoms that remain are fatigue, a little tingling in my face and I still feel a numb feeling during orgasm but somewhat better.
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I got toxic on 50 mg for 2 weeks some got toxic on 2mg etc.
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Hi! I started taking vitamin b6 about 3 weeks ago. In a couple days I started feeling bad, dizzy, tingling on hands and feet, was hard to walk etc. When I stopped I started feeling much better and I went to have some alcohol with friends for 2 nights. I dont know what happened but I have been feeling terrible since then. Cant sleep because of inner shaking and tingling weakness. Its really bad..
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I'm sorry. How are you feeling now? Are you better?
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Just diagnosed with toxicity...74....from too much supplementation...first brought on by a doctor several yrs ago?  Never questioned it. I am now convinced that I never needed b vitamins and that magnesium deficiency was my problem. I wish I would have been smarter. NEVER took supplements before except when I was pregnant. Seeing all these posts, I now wonder too, if my prenatal vitamin played a role in my migraines and severe abdominal pain while I was pregnant...in addition to very high blood pressure from...severe anxiety....and probably low magnesium. To tell you the truth, I had pitocin too and that is what I feel like now...severe burning all over my body, in my tongue too, severe coldness, shaking. I've always been cold but this is ridiculous. Some pins in my big toe and severe anxiety. Very pissed off. My neurologist removed all b vitamins but he isn't completely convinced it is all my problems. I also developed erythromalalgia several yrs ago....BUT, that also started with the b6...so did it trigger the erythromalalgia? Now I wonder but can't really find any literature to support it. I've had vascular issues all my life...very very cold extremities and nose, that have just progressed to this...I guess. I can remember weird vascular things as a kid so who knows.  Also have Meniere's so my nerves are shot anyway. Just a tentative diagnosis too of SICCA Syndrome but I wonder now...b6!!!

Just had the biopsy for small fiber neuropathy...hoping for a negative. EMG normal. NO autoimmune anything. I should be the picture of health.

Just a few weeks off b vitamins. My left foot skin feels more normal now...skin felt like a plastic bag...not a sock feeling. I feel more comfortable with socks on. I actually feel really good when I walk on the treadmill. Not really any fatigue. Never had any numbness really except when feet very cold...which is my normal anyway. Hoping to heal. Scared.
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I'm burning everywhere. Very depressed over this. My b6 was 13 before a doctor got hold of me.
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Hi Thanks for the update. I needed some good news. Can I ask what your levels were to begin with and what dose of b6 you were taking? My level was 74.
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just found out my level was 142 (2-21) range.
My symptomay are mainly a burning of my skin - tops of hands, feet, thighs, cheeks, ugh. I hope stopping the supplements and eating a low b6 diet helps.
I think I am getting a bit depressed from all of this not feeling well.
Testing for everything including MRIs.
Only other think it could be is menopause or lyme - band 41 is positive for igg
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Blood tests for Lyme are terribly inaccurate.  
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for me personally it took about 4-5 weeks to feel fairly normal again. But after about 18 months or so i currently have a "flare up" to my dismay. Paresthesias and clammy hands and feet. Very irritating. And yup, i was worked up for other diagnoses such as MS like so many people here.
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I got B6 toxic 2 years ago by taking Emergencee supplement. Tingling all over, temperature regulation problems, jumping muscle twitches. Got thorough near work up including brain MRI and all was good.

Went 2 years without symptoms but recently was taking NSAIDs for other pains and noticed my B6 toxicity symptoms returned. Ive read that NSAIDs can LOWER your b6 levels, but am wondering if anyone heard of it causing a rise in B6??
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Hello.  I am new to this site.  I have all of the common symptoms described by most of you, twitching and jerks caused by misfiring nerves (according to the tests the neurologist conducted), fatigue, muscle aches, trigeminal neurologia, peripheral neuropathy, gastroenterology issues, fibromyalgia, and dizziness.  The neurologist conducted many tests to determine the reasons and he found two possibilities:  Mixed ConnectiveTissue Disease (which was confirmed by a rheumotologist) and B6 toxicity   At the time of the tests my B6 was 38 on a scale provided by my lab as 1 to 21 as normal.  Since my B6 was just mildly high, we just preceded with treatment for the Mixed Connective Tissue Disease.  My GP followed up and now I have a score of 84, which is more than double.  Here is my issue:  I am not taking any supplements or vitamins at all.  I can not for the life of me figure out where I am getting the B6.  I don't eat cereal or hight amounts of spinach.  Everything I read says you have to ingest the B6 in order to get toxic levels but that does not seem to be the case for me.  Any ideas as to what my next step should be?  It seems to me likely that both the autoimmune disease and the B6 are causing my problems so I should probably get this resolved.  Who should I see in order to figure out the source of the B6?
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Have a look at tables of which foods are high in B6 (egg yolks and pistachios are examples; red peppers also).  Scrutinize the ingredients of your beverages and processed foods.  It gets added to far too many foods, which is crazy for those of us who have toxicity.
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What changes did you make to your diet?
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Does anyone have a diet that is low in B6?
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I noticed that you wrote this paragraph in 2006. How are you feeling now?
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It seems like you might have overall problems absorbing and  metabolizing phosphate chemicals in general. B6 is a phosphate chemical.

Try going on a low phosphate diet. I did and it helped me. (I will get dizzy if I drink sodas, or eat soy products or drink coffee or black tea or green tea, or eat oatmeal, or eat beans or lentils or soy sauce///// all of these foods are high in phosphates.... and you might be having a B6 issue just because you can't absorb and metabolize phosphates very well. (also avoid eggs and mayonnaise and vegannaise which is high in soy)

Here is what I eat and you could try eating and see if it helps. (all of these foods are low in phosphates/phosphorus)

organic potatoes, organic olive oil and coconut oil.
lean beef or bison (not more than 3 oz per day. Its the only part of my diet that is high in phosphorus, but it seems to "pay for itself" eg help itself be absorbed because it is so high in amino acids to help make the absorbing and metabolizing digestive enzymes.

I also eat romaine lettuce salads with olive oil and avocadoes.

and I eat oranges, bananas, Odwalla oj, raspberries, and mangoes. I know this diet is sparse, but since I have been on it, no more dizzyness or nausea or fatigue or pain.

Try this and see how it works and if you seem to feel better and phosphates are the issue, you could then work in this powdered magnesium carbonate product called CALM and take about 1/4 tsp bef each meal because that will help absorb excess phosphate that might be in any food you eat.

(Also avoid msg and msg chemicals like the plague)

You might think I'm crazy, but try this. It worked for me. It is easy, inexpensive and not any type of diet a doctor would have any problem with.

If you try it, let me know how it works for you.

An easy and quick way to see if I'm on the right track with this for you is to try drinking some dr. pepper and if you feel dizzy or anxious or have to pee alot after doing so. Bingo. that's it. you are not very able to absorb and metabolize phosphate chemicals.

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Are you taking any magnesium? and if so, what kind? It takes magnesium to help process B vitamins and so taking too much B vitamins can deplete your magnesium. B6 is also a phosphate chemical, so if you have been taking too much, your phosphate levels can go too high and the brain fog etc is all linked to too high phosphate levels. Our bodies can only absorb so much phosphate at a time and if you put more than that in your body, you could get aches, pains, blurry vision, dizzyness, and brain fog.

According to Dr. Robert Thompson, who wrote The Calcium Lie: What Your Doctor Doesn't Know Could Kill You, if you are magnesium (and other minerals) deficient, you will not be able to properly absorb any vitamins. So it is best to get some sea salt (good balance of all minerals) and take Magnesium Chloride (Trace Minerals Research "Mega Mag" ionic liquid magnesium chloride is a good brand), and start taking these two things before taking any vitamins, since without proper mineral and esp. magnesium levels, you won't be able to properly absorb vitamins, esp B complex vitamins and they, then could cause problems.

Also, if you have a CBS mutation, that can make you sensitive to sulphur/ phosphates and so epsom salts, which are magnesium sulfate, might not be good for you.

I would suggest, til you get over your symptoms, to avoid foods high in phosphates: Coffee, Black Tea, Green Tea, all sodas (esp colas and dr. pepper), legumes (beans, peas, lentils, peanuts), oatmeal and corn.

Also avoid foods high in sulfur chemicals: onions, garlic, eggs, lunch meats (with sulfites)

If you eat these things, you might notice a rise in symptoms.

The best to eat for right now would be:
lean meat (buffalo is good) cooked w/ olive oil or coconut oil, Romaine lettuce and oranges and oj (all high in Folate), mangoes, bananas, organic potatoes, raspberries, zucchini, crook neck squash, okra, avocados.
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Some of this is incorrect.
15811011 tn?1443219187
Hey everyone i was on this forum had set new profile up.  Im over 2 years healing still have lot fatuige issues lot tingling pain is gone no more burning.My fatuige is worse after exersise im trying to eat healthy diet high b6 foods dont cause me anymore pain.      
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Avatar universal
Please provide links or information as to diets for B6 toxicity. I'm currently greater than 100. I'm not sure how to drop B6 outside of diet and water. Any guidance would be helpful.
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I too am searching for information on how to drop my current toxic levels of B6 which have been attributed to the extreme dizziness and nausea/lack of appetite that I have.Sometimes the symptoms are severe and other times they are minimal, but wither way they preclude me from having a normal life.
Please advise. Thank you whoever is out there reading this and has the compassion and experience to offer suggestions.
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Hi,

yes it gets MUCH worse before it gets better.
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