This does'nt happen evreyday thank God. I'm guessing maybe 4-6 days out of the month and not really back to back day's. I start to wake up feeling pretty good, no reasons to even feel crappy or depressed or down at all. I usually wake up at around 9 or 10a.m. feeling pretty good, nothing significant or serious triggers my mood change it usually happens slowly but I can feel it, I feel really, really,sad, anxious, irritable, fatigue, and down. It usually changes, say around 3-4p.m. and I can start to feel myself slowly go back up to feeling normal, like around 8-9p.m.. In that timeframe of feeling sad and really down, I tell myself it will pass as the time passes, even knowing that, I can't get myself to just accept it's only every once in awhile and it does'nt last long but it still does'nt make it easier to deal with. It's a pretty miserable long 6-7 hours and it's hard to get through them. Nothing seems to ease that time frame. I can't concentrate, or focus on anything so it's hard to get my mind off of that nasty rotted, blah feeling. I've tried reading, watching t.v. taking a walk, talk to freinds or family, or even talk with them through these feelings, why? Does anybody have this problem in the thyroid community? I have been diagnosed with depression have been prescribed zoloft and that pretty much helps me with my depression, but this is something different, not normal, not just depression, I just can't put my finger on exactly how to explain this thing. Is it more than a thyroid/hormonal thing or should I start looking at stronger anti depressants? I like how zoloft helps with the other days, and I don't want to be on another antidepressant or switching to different medications because it took me forever to find the right antidepressant with the zoloft. I had these thoughts/feelings for the past 5yrs and it has been getting harder and stronger and even more unbearable lately. I had spoke to my Dr. about it and he says it is my thyroid and justs leaves it at that, and so would I, but like I said it's becoming more and more uncomfortable and unbearable to handle, like it's getting bigger as time passes and I can't ignore it anymore. I have to do something about it, before it does get out of hand, what are my options here? I don't want to change or add on another antidepressant, I cant just slide through those days anmore as I use to when it was dealable, what do I do? for people who don't understand what its like to go through a day like that, I explain to them that this is how it feels: Imagine your car got stolen, you had a whole month's worth of your earnings in that glove box, it's your fault because you left the keys in the ignition and the doors unlocked, oh by the way they ran over your family pet on the way out,and oh by the way again your job called your fired, oh yeah the landlords here he wants yall out this week, and your kids are skipping school and the principle is expecting you to be there in fifteen minutes or she's reporting you to child protective services, but ohhhh wait you dont have a ride up there, ohhhh I can go on forever with that one on how to explain to people how you feel but unless you been there nobody understands. I just wanna know is there anyone like me out there like this in this forum? please help me. Sorry it wasnt suppose to end up this long.