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Synthroid or Generic (levothyroxine)
My question concerns Synthroid.

On Dec 04, 2006 at 12:00AM, Mark Lupo, M.D. said in answer to a question:

"Levoxyl is another brand -- there is no advantage to Synthroid.  Protecting the brand has advantages over generic regarding consistency of levels. the generic is levothyroxine".

Huh? What on earth does that answer mean? "Protecting"? "consistency of levels?" It sounds like he's saying that the Synthroid is preferable to the generic (but the same as Levoxyl)?

Yes?

If so, why would a brand name be better than a generic? The general rule (for those who don't profit from the sale of brand-name drugs) has always been: When a drug patent runs out, a (usually much) less-expensive generic drug comes onto the market, which is chemically and medically equivalent to the brand-name drug. If he's saying what I think he's saying, I'd like to know what the difference here could possibly be.  How could the the equivalent be different?...and if its different, how could it be equivalent?

If not, what does the other answer mean?  


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Avatar universal
Dont know but I take generic and I feel fine.  I'd be interested in other responses too.  
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87651 tn?1259606003
My Endo Dr told me he preferred Synthroid over generic due to the fillers in the generic brand. He said alot people do not adjust to the fillers in the generic therefore they have more symptoms, but again, this what he told me. I am sure alot of people do well on generic. Everyone is different and reacts differently to meds.
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87651 tn?1259606003
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484221 tn?1210954107
i have been on both on and off for 10 + years andi can't tell a difference.  i think the only difference is the name its the same exact stuff  it is mostly for people who can't afford a 15 dollar prescription like me i go to walmart n get levothroxyn and its only 4 dollars. but any ways just thought i would add that
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484221 tn?1210954107
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176557 tn?1222893911
My surgeon put me on generic levothyroxine after my TT.  When my endo found out I was on the generic version, he rolled his eyes and immediately prescribed synthroid and I have been on it ever since.  I have to say, I have had better luck on synthroid, but can't say if it is because of the brand name or maybe an increased dosage, I can't remember which came first.

The brand names have more consistency in dosage and ingredients, according to what I have read.

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176557 tn?1222893911
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213044 tn?1236531060
There are rules and standards that have to be followed in the manufacture of drugs.

Brand name thyroid drugs all have levothyroxine in them, but the different brands use different fillers. That is how they can get around the patent Synthroid has.

Brand name drugs are held to a stricter requirement for the amount of active ingredient in each pill, and the shelf life of the active drug. Brand name drugs are allowed 5-10% +/- variation from what the label says to what the drug measures fresh and at end of shelf life.

Generics are allowed a variation of 25%, plus or minus, and there is no guarantee that the pharmacy will stock the same generic from month to month. So, the fillers in the generic may change because the manufacturer has changed. Several companies make generic Levothyroxine, but there is no set formula for what the fillers must be.

You have a better chance of keeping your dosage and your hormone levels constant by avoiding generics.

I'm on a few generic medications. Neither my GP nor my Endo will allow me to take generic thyroid meds.
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213044 tn?1236531060
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197575 tn?1215536224
I know synthroid is used for cancer supression because it is more consistent- generic may use different fillers.  I have friends with hypothyroidism, and take generic.  Cancer survivors need their levels supressed and consistent.
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197575 tn?1215536224
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Avatar universal
I have been on both and I have to say Levothyroxine I felt tired and crappy. I did not menstrate while taking it. Now that I am on Synthryoid i have been symptom free and and regular cycles!!! I am definitely an advocate for brand name!  
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