I have been researching different data and started using NORCO 15 years ago. The first few times I got off it, I used Imodium and after a few weeks I was fine. I went off them about a year ago (never abused) took them as prescribed for legit chronic pain. However, they made me so lethargic and now when I withdrew cold turkey 3 weeks ago, the horrible wheezing and cough.. It was the worst ever. However, the last time i withdrew over a year ago, I had so many GI tests and nothing was found. I am reading that the same neurotransmitters in the brain effect the digestive system and I am almost positive it has been altered. I hate the chronic diarrhea. I have tried Imodium, Metamucil, Viberze and nothing works... I went back on Norco in May after a bad car accident and 6 months later I have been off for 3 weeks and the diarrhea is awful. I loved having regular bowel movements on the norco and yes there was some constipation. I am shocked that the medical community has not addressed this especially since they are now discouraging opiates for chronic pain. My pain is manageable, the diarrhea, not at all. I want to go back to work... how can I with this going on.