I have taken 300 ER vs 8 x 50mg, per day for years, for per. neuropathy. Sometimes I took more, and only sporadically was I "affected"by that. Has seemed like a very safe pain med option. Never remember a problem quitting cold turkey ( or from 8 10/500 hydro's / day either for that matter ).
Isn't that a little odd ?
I do seem to have a HUGE tolerance, so they say. I don't drink or smoke ( good thing with the acet.in the hydro, eh? )