Hi, well, it IS absolutely true that a lot of hormonal things go on at that age. Absolutely. I think it is as confusing for the kids going through it as their parents! I think I'd take watch and see approach. Listen to your son and encourage him to talk to you. And listen for cues. Anxiety and depression can look like different things most definitely for different people. Depersonalization is a symptom But it doesn't always have to be. I'd look to see if other things are present as well. I have a son who is anxious (and one who isn't) and you notice patterns and wording of things. If he stops wanting to do things he likes or be with friends, wants to sleep all the time or tells you he can't sleep, mentions he's worried or nervous all the time, etc. Keep a little mom journal if that is easiest and judge when you need to step in for help. And most pediatricians are pretty in tune these days. At my son's last well visit, both did mental health questionnaires. You can also talk to his school counselor. I've found mine to be awesome at recommendations and resources. good luck.