Is there a safe and effective tranquilizer to take for flight anxiety? I tried the generic brand of xanax (alprazelam) a few years ago and it had absolutely zero effect. Maybe I just didn't take enough but the prescription is over 5 years old now and I would be afraid to experiment. Is valium a better options? I don't like having to buy and consume alcohol in airports or on planes and don't like being impaired while on traveling on business, so an effective tranquilizer would be ideal - also one that wouldn't have a bad interaction if I had wine with dinner after arriving at my destination. Is there such a prescription that I could ask my physician to prescribe?