I have POTS and have a ton of twitching!!! Glad to see I'm not the only one like I thought I was!
I don't have a diagnosis yet but I've been twitching ever since 2002, when I began noticing muscle fatigue. I've been told that twitching is relatively common and isn't cause for concern if it doesn't accompany significant muscle weakness/atrophy, that's what a neuro told me.
Yes, I have 2 forms of POTS. Neuropathic & Deconditioning. The Neuropathic has to be the worst part for me, I always describe it as wanting to jump out of my skin. Mine is most noticeable when I lay down to sleep.