I feel your pain! I am just now getting desperate enough to research what's causing this. I am still researching but I know that most likely I'm going to have to do a major diet change. I really think everyones problems are stemming from unhealthy malfunctioning bodies. The only real cure is to get healthier and help your body heal. I'm specifically looking into gut healing and liver. I hope you get relief fast! Your must be worse than mine. I'm so sorry!
I have been using Aveeno lotion on my feet. It worked no more bumps!
I have what most of your are describing and have had it for many years. The first time I had an "outbreak" my doctor took a sample of the fluid and tested it. It was not sweat as some of you said it might be, instead the lab said it was Serum. Because of this lab result and the symptoms that have been described many times in this discussion it was diagnosed as Dyshidrosis.
Search for the term Dyshidrosis and you will find the clinical description and that there is no known cause. With out a known cause there cannot be cure and one treatment will work for some and not other probably because the causation varies so people will have to find what works for them to resolve the symptoms. Personally I use peroxide or rubbing alcohol twice a day on the affected area, morning and night, to prevent infection especially after the blisters open or leak fluid. When some blisters do open up they begin to itch so I use an over the counter Hydrocortisone cream after cleaning the area.
If you can determine your personal trigger try removing that trigger from your environment/diet. Mine seems to heat related as my outbreaks mostly occur in the hotter months of the year I try to wear that have good ventilation once temperatures get above 80 degrees. For me keep my feet cool seems to have cut down on the number of out breaks I have.
Finally for those of us that share our homes with others you will be happy to know it is not contagious. Most of you have probably figured this out by now since it only happens on one foot and if it was contagious like foot fungus you would have the problem on both feet.
Hope this helps and gets you back on your feet soon.
"If holistic medicine worked we wouldn't need modern medicine."
CORRECTION - the cream I mentioned is not a steroid, it's an anti-fungal, although the condition isn't due to a fungal problem - as I was tested and nothing was detected. However it does work. Maybe one day they will discover what causes this problem.
I have had this problem, it began 10 years ago I suffered through exactly what you describe for a good year and then my Dr prescribed Mentax cream (steroid) and it cleared up in about a month and only came back every couple of years for a brief time (and wasn't nearly as horrible) and went away again on its own. Usually it would occur in the summer when I wear flip flops or sweat a lot or anything that caused my feet to get dirty (it began on both feet before the cream, but has only been my left foot now when it occurs). My Dr told me it wasn't fungal but a skin sensitivity. I haven't used any cream in 7 years simply because it's never bad enough for that since the first treatment.
Mine activates if my right foot touches the grond or I get my sock soiled. Right foot. Itches like demons n hurts like hell the deeper they are I.e. heel offoot. Im in hell. I need help. Nothing but prednisone helps a little and aloe vera gel 100% clear. It is NOT athletes foot.. a food allergy an ph imbalance or some aura. Sleep deprivation and stress make ANY health issue worae. Somebody help. Im ready to cut my foot off. Ive done EVERYTHING else it seems.