no i dont think so as long as you dont do it too tight i had varicose vein they told me to where this leg compression thing and i dont think the varicose vein suppose to hurt you. if you think its the varicose vein hurting you you should talk to the doctor. my didnt hurt me at all hopefully this will help
Have you tried putting something between the knee brace and the varicose vein, i.e. a piece of soft cloth, lamb's wool?
I would also recommend having your physician verify the brace is not aggravating the vein.