Aa
Coffee and painkillers - for those who don't know
I was halfway through my second cup of coffee at work today when I ran across this. I promptly threw the rest out. No more than one cup for me at the MOST from now on. And never with painkillers. It can be lethal for some.
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"New York: You could be hurting your liver, if your treatment for a hangover involves taking stacks of painkillers, and chasing it with mugs of coffee. Yes, this is true.
A new study by US researchers has revealed that caffeine can respond with the painkillers to triple the levels of noxious toxins in your blood and give rise to liver damage.
And, in large quantity, the effects could be lethal for people who are already suffering from liver problems.
Study’s lead researcher, Dr Sidney Nelson of the University of Washington in Seattle, said, “People should be informed about this potentially harmful interaction. The bottom line is that you don't have to stop taking paracetamol (painkiller) or caffeine products, but you do need to monitor your intake more carefully when taking them together, especially if you drink alcohol.”
The researchers came to the decision after producing an artificial enzyme that is otherwise formed when the liver crashed the painkiller drug, making use of genetically engineered bacteria and then added up caffeine to the mix to analyze the result on rodents.
They detected that the toxin levels in the liver of the rats increased threefold when caffeine was there. Caffeine was also found to intensify liver damage in those already have liver problems.
But, according to the scientists, coffee, taken in large doses, alone can also result into grave health troubles.
The study results have been reported in the journal ‘Chemical Research in Toxicology,’ published by the American Chemical Society."
-----------------------------------------------------------------------------------
"New York: You could be hurting your liver, if your treatment for a hangover involves taking stacks of painkillers, and chasing it with mugs of coffee. Yes, this is true.
A new study by US researchers has revealed that caffeine can respond with the painkillers to triple the levels of noxious toxins in your blood and give rise to liver damage.
And, in large quantity, the effects could be lethal for people who are already suffering from liver problems.
Study’s lead researcher, Dr Sidney Nelson of the University of Washington in Seattle, said, “People should be informed about this potentially harmful interaction. The bottom line is that you don't have to stop taking paracetamol (painkiller) or caffeine products, but you do need to monitor your intake more carefully when taking them together, especially if you drink alcohol.”
The researchers came to the decision after producing an artificial enzyme that is otherwise formed when the liver crashed the painkiller drug, making use of genetically engineered bacteria and then added up caffeine to the mix to analyze the result on rodents.
They detected that the toxin levels in the liver of the rats increased threefold when caffeine was there. Caffeine was also found to intensify liver damage in those already have liver problems.
But, according to the scientists, coffee, taken in large doses, alone can also result into grave health troubles.
The study results have been reported in the journal ‘Chemical Research in Toxicology,’ published by the American Chemical Society."
yeah, aside from being caffiene a nasty form of speed, it also strips you of vital minerals and can damage the heart.
Like a girl I know lost so many electroyletes working at starbucks she ended up in a coma.
love those lattes to death she did.....well almost.
mb
Like a girl I know lost so many electroyletes working at starbucks she ended up in a coma.
love those lattes to death she did.....well almost.
mb
If coffee had been discovered during the sixties it would be hailed as the greatest herbal remedy ever found! Sooo good on so many levels, as everthing best if used in moderation. jerry
Coffee.............I admit I am 100% addicted, thats why i had remembered all those studies...you see you CAN find one study that says 'this' and one study that says 'that' which is important for everyone to remember in ALL aspects of treatment. It doesn't prove anything is necessarily 100% correct though so you have to be careful (I'm talking about meds and durations and things not really about coffee here!)
Now move over it's 5pm and I'm dying for an espresso (just made one for one of the executives who's wife just had a baby to be nice to him) and man that smell.....ah after all this talk I'm dying to slurp one down too!
Now move over it's 5pm and I'm dying for an espresso (just made one for one of the executives who's wife just had a baby to be nice to him) and man that smell.....ah after all this talk I'm dying to slurp one down too!
I wouldn't get going in the morning without my daily ration of coffee!!!
I was on a trial earlier this year for triple therapy and I was restricted to two 8oz cups of coffee per day so it must be OK as drug companies don't want trial participants to use substances that will skew the results.
As a matter of prudence I have decided to stick with that restriction for the remainder of my tx.
Mmmmmm, coffee, slurp, slurp, yummmmm!!!!!!
I was on a trial earlier this year for triple therapy and I was restricted to two 8oz cups of coffee per day so it must be OK as drug companies don't want trial participants to use substances that will skew the results.
As a matter of prudence I have decided to stick with that restriction for the remainder of my tx.
Mmmmmm, coffee, slurp, slurp, yummmmm!!!!!!
Thanks nygirl, I'm having my afternoon cup as I type this! lol
"Coffee is Number One Source of Antioxidants" - I never would have guessed that in a million years. Amazing.
And to Portann, yes - I think as long as you're not combining painkillers, you're ok.
- Joe
"Coffee is Number One Source of Antioxidants" - I never would have guessed that in a million years. Amazing.
And to Portann, yes - I think as long as you're not combining painkillers, you're ok.
- Joe
My opinion too - like chocolate cake one piece once in a while won't do anything but an entire cake a day well........ha..............we wouldn't need to worry about dying from caffeine for sure!
Hi Granitekonig,
That's timely because I'm quite sure there was recent thread here that cited a study saying ONE cup of coffeee a day is beneficial for the liver. The reason I remember it is that I'm not at all a coffee drinker by inclination and I went out deliberately to sit in a coffee shop and drink this new found 'medicine'.
Anyway, drinking coffee wasn't my thing, so I didn't adhere to it but it seems like for every study saying one thing, there's another saying the opposite. I have no idea as to the prestige of the journal quoted, The American Chemical Society.
As long as you're not taking painkillers, a morning cup of coffee can probably bring a lot of happiness and little harm.
That's timely because I'm quite sure there was recent thread here that cited a study saying ONE cup of coffeee a day is beneficial for the liver. The reason I remember it is that I'm not at all a coffee drinker by inclination and I went out deliberately to sit in a coffee shop and drink this new found 'medicine'.
Anyway, drinking coffee wasn't my thing, so I didn't adhere to it but it seems like for every study saying one thing, there's another saying the opposite. I have no idea as to the prestige of the journal quoted, The American Chemical Society.
As long as you're not taking painkillers, a morning cup of coffee can probably bring a lot of happiness and little harm.
And one more so you can get that afternoon cup of java!
especially this part is good and verifies previous post.......
"Besides keeping you alert and awake, coffee has been linked to an increasing number of potential health benefits, including protection against liver and colon cancer, type 2 diabetes, and Parkinson's disease, according to some recently published studies."
Coffee is Number One Source of Antioxidants
WASHINGTON, Aug. 28 � Coffee provides more than just a morning jolt; that steaming cup of java is also the number one source of antioxidants in the U.S. diet, according to a new study by researchers at the University of Scranton (Pa.). Their study was described today at the 230th national meeting of the American Chemical Society, the world's largest scientific society.
"Americans get more of their antioxidants from coffee than any other dietary source. Nothing else comes close," says study leader Joe Vinson, Ph.D., a chemistry professor at the university. Although fruits and vegetables are generally promoted as good sources of antioxidants, the new finding is surprising because it represents the first time that coffee has been shown to be the primary source from which most Americans get their antioxidants, Vinson says. Both caffeinated and decaf versions appear to provide similar antioxidant levels, he adds.
He cautions that high antioxidant levels in foods and beverages don't necessarily translate into levels found in the body. The potential health benefits of these antioxidants ultimately depends on how they are absorbed and utilized in the body, a process that is still poorly understood, says Vinson, whose study was primarily funded by the American Cocoa Research Institute.
The news follows a growing number of reports touting the potential health benefits of drinking coffee. It also comes at an appropriate time: Coffee consumption is on the rise in the United States and over half of Americans drink it everyday, according to the National Coffee Association.
Antioxidants in general have been linked to a number of potential health benefits, including protection against heart disease and cancer. For the current study, Vinson and his associates analyzed the antioxidant content of more than 100 different food items, including vegetables, fruits, nuts, spices, oils and common beverages. The data was compared to an existing U.S. Department of Agriculture database on the contribution of each type of food item to the average estimated U.S. per capita consumption.
Coffee came out on top, on the combined basis of both antioxidants per serving size and frequency of consumption, Vinson says. Java easily outranked such popular antioxidant sources as tea, milk, chocolate and cranberries, he says. Of all the foods and beverages studied, dates actually have the most antioxidants of all based solely on serving size, according to Vinson. But since dates are not consumed at anywhere near the level of coffee, the blue ribbon goes to our favorite morning pick-me-up as the number one source of antioxidants, he says.
Besides keeping you alert and awake, coffee has been linked to an increasing number of potential health benefits, including protection against liver and colon cancer, type 2 diabetes, and Parkinson's disease, according to some recently published studies. But there's also a downside: Java can make you jittery and cause stomach pains, while some studies have tied it to elevated blood pressure and heart rates. More research is needed, particularly human studies, to firmly establish its health benefits, Vinson says.
While the findings would seem to encourage people to go out and drink more coffee, Vinson emphasizes moderation. "One to two cups a day appear to be beneficial," he says. If you don't like coffee, consider drinking black tea, which is the second most consumed antioxidant source in the U.S. diet, Vinson says. Bananas, dry beans and corn placed third, fourth and fifth, respectively.
But don't forget about fresh fruits and veggies, the researcher cautions. "Unfortunately, consumers are still not eating enough fruits and vegetables, which are better for you from an overall nutritional point of view due to their higher content of vitamins, minerals and fiber," Vinson says. Dates, cranberries and red grapes are among the top fruits for antioxidants on the basis of concentration (antioxidants per serving size), he says.
The American Chemical Society is a nonprofit organization, chartered by the U.S. Congress, with a multidisciplinary membership of more than 158,000 chemists and chemical engineers. It publishes numerous scientific journals and databases, convenes major research conferences and provides educational, science policy and career programs in chemistry. Its main offices are in Washington, D.C., and Columbus, Ohio.
especially this part is good and verifies previous post.......
"Besides keeping you alert and awake, coffee has been linked to an increasing number of potential health benefits, including protection against liver and colon cancer, type 2 diabetes, and Parkinson's disease, according to some recently published studies."
Coffee is Number One Source of Antioxidants
WASHINGTON, Aug. 28 � Coffee provides more than just a morning jolt; that steaming cup of java is also the number one source of antioxidants in the U.S. diet, according to a new study by researchers at the University of Scranton (Pa.). Their study was described today at the 230th national meeting of the American Chemical Society, the world's largest scientific society.
"Americans get more of their antioxidants from coffee than any other dietary source. Nothing else comes close," says study leader Joe Vinson, Ph.D., a chemistry professor at the university. Although fruits and vegetables are generally promoted as good sources of antioxidants, the new finding is surprising because it represents the first time that coffee has been shown to be the primary source from which most Americans get their antioxidants, Vinson says. Both caffeinated and decaf versions appear to provide similar antioxidant levels, he adds.
He cautions that high antioxidant levels in foods and beverages don't necessarily translate into levels found in the body. The potential health benefits of these antioxidants ultimately depends on how they are absorbed and utilized in the body, a process that is still poorly understood, says Vinson, whose study was primarily funded by the American Cocoa Research Institute.
The news follows a growing number of reports touting the potential health benefits of drinking coffee. It also comes at an appropriate time: Coffee consumption is on the rise in the United States and over half of Americans drink it everyday, according to the National Coffee Association.
Antioxidants in general have been linked to a number of potential health benefits, including protection against heart disease and cancer. For the current study, Vinson and his associates analyzed the antioxidant content of more than 100 different food items, including vegetables, fruits, nuts, spices, oils and common beverages. The data was compared to an existing U.S. Department of Agriculture database on the contribution of each type of food item to the average estimated U.S. per capita consumption.
Coffee came out on top, on the combined basis of both antioxidants per serving size and frequency of consumption, Vinson says. Java easily outranked such popular antioxidant sources as tea, milk, chocolate and cranberries, he says. Of all the foods and beverages studied, dates actually have the most antioxidants of all based solely on serving size, according to Vinson. But since dates are not consumed at anywhere near the level of coffee, the blue ribbon goes to our favorite morning pick-me-up as the number one source of antioxidants, he says.
Besides keeping you alert and awake, coffee has been linked to an increasing number of potential health benefits, including protection against liver and colon cancer, type 2 diabetes, and Parkinson's disease, according to some recently published studies. But there's also a downside: Java can make you jittery and cause stomach pains, while some studies have tied it to elevated blood pressure and heart rates. More research is needed, particularly human studies, to firmly establish its health benefits, Vinson says.
While the findings would seem to encourage people to go out and drink more coffee, Vinson emphasizes moderation. "One to two cups a day appear to be beneficial," he says. If you don't like coffee, consider drinking black tea, which is the second most consumed antioxidant source in the U.S. diet, Vinson says. Bananas, dry beans and corn placed third, fourth and fifth, respectively.
But don't forget about fresh fruits and veggies, the researcher cautions. "Unfortunately, consumers are still not eating enough fruits and vegetables, which are better for you from an overall nutritional point of view due to their higher content of vitamins, minerals and fiber," Vinson says. Dates, cranberries and red grapes are among the top fruits for antioxidants on the basis of concentration (antioxidants per serving size), he says.
The American Chemical Society is a nonprofit organization, chartered by the U.S. Congress, with a multidisciplinary membership of more than 158,000 chemists and chemical engineers. It publishes numerous scientific journals and databases, convenes major research conferences and provides educational, science policy and career programs in chemistry. Its main offices are in Washington, D.C., and Columbus, Ohio.
Here is one good reason for you! :)
Reduced Risk Of Liver Cancer Linked With Coffee Consumption
Medical News Today 05 Aug 2007
After lung and stomach cancer, liver cancer is the third largest cause of cancer deaths in the world. A new study on the relationship between coffee drinking and the risk of hepatocellular carcinoma (HCC) confirmed that there is an inverse association between coffee consumption and HCC, although the reasons for this relationship are still unresolved.
The results of this study appear in the August 2007 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc.,
At least eleven studies conducted in southern Europe and Japan have examined the relationship between coffee drinking and the risk of primary liver cancer. The current study, led by Francesca Bravi of the Istituto di Ricerche Farmacologiche Mario Negri in Milan, Italy, was a meta-analysis of published studies on HCC that included how much coffee patients had consumed. Researchers combined all published data to obtain an overall quantitative estimate of the association between coffee consumption and HCC.
The results showed a 41 percent reduction of HCC risk among coffee drinkers compared to those who never drank coffee. "Moreover, the apparent favorable effect of coffee drinking was found both in studies from southern Europe, where coffee is widely consumed, and from Japan, where coffee consumption is less frequent, and in subjects with chronic liver diseases," the researchers state.
They point out that animal and laboratory studies have indicated that certain compounds found in coffee may act as blocking agents by reacting with enzymes involved in carcinogenic detoxification. Other components, including caffeine, have been shown to have favorable effects on liver enzymes. Coffee has also been related to a reduced risk of liver diseases and cirrhosis, which can lead to liver cancer.
"Despite the consistency of these results, it is difficult to derive a causal inference on the basis of the observational studies alone," the authors note. It may be that patients with digestive tract diseases, including liver disorders, naturally reduce their coffee consumption, even though avoidance of coffee is not routinely recommended. Also, they note that the assessment of coffee intake was based on patients' self-reporting, although recall of coffee drinking has been shown to be accurate. The fact that the inverse relationship between coffee drinking and HCC was shown in both southern Europe and Japan suggests a lack of bias in these studies. Allowance for other confounding factors, such as hepatitis B and C, cirrhosis, social class indicators, alcohol use and smoking, also suggests that such factors did not influence the results.
"In conclusion, the results from this meta-analysis provide quantitative evidence of an inverse relation between coffee drinking and liver cancer," the authors state. "The interpretation of this association remains, however, unclear and the consequent inference on causality and worldwide public health implications is still open for discussion."
Article adapted by Medical News Today from original press release.
-----------------------------------------------------------------------------------------------
Coffee drinking and hepatocellular carcinoma risk: A meta-analysis
Abstract
Several studies suggest an inverse relation between coffee drinking and risk of hepatocellular carcinoma (HCC). We conducted a meta-analysis of published studies on HCC that included quantitative information on coffee consumption. Ten studies were retrieved (2,260 HCC cases), including 6 case-control studies from southern Europe and Japan (1551 cases) and 4 cohort studies from Japan (709 cases). The summary relative risk (RR) for coffee drinkers versus non-drinkers was 0.54 (95% confidence interval [CI] 0.38-0.76) for case-control studies and 0.64 (95% CI 0.56-0.74) for cohort studies. The overall RR was 0.59 (95% CI 0.49-0.72), with significant heterogeneity between studies. The overall summary RR for low or moderate coffee drinkers was 0.70 (95% CI 0.57-0.85), and that for high drinkers was 0.45 (95% CI 0.38-0.53). The summary RR for an increase of 1 cup of coffee per day was 0.77 (95% CI 0.72-0.83) from case-control studies, 0.75 (95% CI 0.65-0.85) from cohort studies, and 0.77 (95% CI 0.72-0.82) overall. The consistency of an inverse relation between coffee drinking and HCC across study design and geographic areas weighs against a major role of bias or confounding. Coffee drinking has also been related to reduced risk of other liver diseases, thus suggesting a continuum of the favorable effect of coffee on liver function. However, subjects with liver conditions may selectively reduce their coffee consumption.
Conclusion: The present analysis provides evidence that the inverse relation between coffee and HCC is real, though inference on causality remains open to discussion. (HEPATOLOGY 2007.)
Francesca Bravi 1 *, Cristina Bosetti 1, Alessandra Tavani 1, Vincenzo Bagnardi 2, Silvano Gallus 1, Eva Negri 1, Silvia Franceschi 3, Carlo La Vecchia 1 4
1 Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
2 Dipartimento di Statistica, Università degli Studi di Milano-Bicocca, Milan, Italy
3 International Agency for Research on Cancer, Lyon, France
4 Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy
email: Francesca Bravi (***@****) *Correspondence to Francesca Bravi, Laboratorio di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62-20157 Milan, Italy
Potential conflict of interest: Nothing to report.Funded by:
Italian Association for Cancer Research
Italian League Against Cancer
Italian Ministry of Research (PRIN 2005)
Francesca Bravi is a Fellow of the Rosario Samanin Fund
Reduced Risk Of Liver Cancer Linked With Coffee Consumption
Medical News Today 05 Aug 2007
After lung and stomach cancer, liver cancer is the third largest cause of cancer deaths in the world. A new study on the relationship between coffee drinking and the risk of hepatocellular carcinoma (HCC) confirmed that there is an inverse association between coffee consumption and HCC, although the reasons for this relationship are still unresolved.
The results of this study appear in the August 2007 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc.,
At least eleven studies conducted in southern Europe and Japan have examined the relationship between coffee drinking and the risk of primary liver cancer. The current study, led by Francesca Bravi of the Istituto di Ricerche Farmacologiche Mario Negri in Milan, Italy, was a meta-analysis of published studies on HCC that included how much coffee patients had consumed. Researchers combined all published data to obtain an overall quantitative estimate of the association between coffee consumption and HCC.
The results showed a 41 percent reduction of HCC risk among coffee drinkers compared to those who never drank coffee. "Moreover, the apparent favorable effect of coffee drinking was found both in studies from southern Europe, where coffee is widely consumed, and from Japan, where coffee consumption is less frequent, and in subjects with chronic liver diseases," the researchers state.
They point out that animal and laboratory studies have indicated that certain compounds found in coffee may act as blocking agents by reacting with enzymes involved in carcinogenic detoxification. Other components, including caffeine, have been shown to have favorable effects on liver enzymes. Coffee has also been related to a reduced risk of liver diseases and cirrhosis, which can lead to liver cancer.
"Despite the consistency of these results, it is difficult to derive a causal inference on the basis of the observational studies alone," the authors note. It may be that patients with digestive tract diseases, including liver disorders, naturally reduce their coffee consumption, even though avoidance of coffee is not routinely recommended. Also, they note that the assessment of coffee intake was based on patients' self-reporting, although recall of coffee drinking has been shown to be accurate. The fact that the inverse relationship between coffee drinking and HCC was shown in both southern Europe and Japan suggests a lack of bias in these studies. Allowance for other confounding factors, such as hepatitis B and C, cirrhosis, social class indicators, alcohol use and smoking, also suggests that such factors did not influence the results.
"In conclusion, the results from this meta-analysis provide quantitative evidence of an inverse relation between coffee drinking and liver cancer," the authors state. "The interpretation of this association remains, however, unclear and the consequent inference on causality and worldwide public health implications is still open for discussion."
Article adapted by Medical News Today from original press release.
-----------------------------------------------------------------------------------------------
Coffee drinking and hepatocellular carcinoma risk: A meta-analysis
Abstract
Several studies suggest an inverse relation between coffee drinking and risk of hepatocellular carcinoma (HCC). We conducted a meta-analysis of published studies on HCC that included quantitative information on coffee consumption. Ten studies were retrieved (2,260 HCC cases), including 6 case-control studies from southern Europe and Japan (1551 cases) and 4 cohort studies from Japan (709 cases). The summary relative risk (RR) for coffee drinkers versus non-drinkers was 0.54 (95% confidence interval [CI] 0.38-0.76) for case-control studies and 0.64 (95% CI 0.56-0.74) for cohort studies. The overall RR was 0.59 (95% CI 0.49-0.72), with significant heterogeneity between studies. The overall summary RR for low or moderate coffee drinkers was 0.70 (95% CI 0.57-0.85), and that for high drinkers was 0.45 (95% CI 0.38-0.53). The summary RR for an increase of 1 cup of coffee per day was 0.77 (95% CI 0.72-0.83) from case-control studies, 0.75 (95% CI 0.65-0.85) from cohort studies, and 0.77 (95% CI 0.72-0.82) overall. The consistency of an inverse relation between coffee drinking and HCC across study design and geographic areas weighs against a major role of bias or confounding. Coffee drinking has also been related to reduced risk of other liver diseases, thus suggesting a continuum of the favorable effect of coffee on liver function. However, subjects with liver conditions may selectively reduce their coffee consumption.
Conclusion: The present analysis provides evidence that the inverse relation between coffee and HCC is real, though inference on causality remains open to discussion. (HEPATOLOGY 2007.)
Francesca Bravi 1 *, Cristina Bosetti 1, Alessandra Tavani 1, Vincenzo Bagnardi 2, Silvano Gallus 1, Eva Negri 1, Silvia Franceschi 3, Carlo La Vecchia 1 4
1 Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
2 Dipartimento di Statistica, Università degli Studi di Milano-Bicocca, Milan, Italy
3 International Agency for Research on Cancer, Lyon, France
4 Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy
email: Francesca Bravi (***@****) *Correspondence to Francesca Bravi, Laboratorio di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62-20157 Milan, Italy
Potential conflict of interest: Nothing to report.Funded by:
Italian Association for Cancer Research
Italian League Against Cancer
Italian Ministry of Research (PRIN 2005)
Francesca Bravi is a Fellow of the Rosario Samanin Fund
There have actually been studies done that showed that coffee could be GOOD for the liver. Yup. Take every little study with a grain of salt, granite, for every study you find pro something you can easily find something against.
Have your cup of Joe and enjoy it. Unless you are scarfing down oxycontins like there is no tomorrow - you'll be fine.
If I knew how to go back and look in here (after all my years here you would think I could) and find the old study....the "pro-coffee" study, I'd post it up. I'll try to find it.
Coffee, like anything else in MODERATION is fine. If that were not true I would be long long dead (and probably from doing a lot of things NOT in moderation).
Debby
Have your cup of Joe and enjoy it. Unless you are scarfing down oxycontins like there is no tomorrow - you'll be fine.
If I knew how to go back and look in here (after all my years here you would think I could) and find the old study....the "pro-coffee" study, I'd post it up. I'll try to find it.
Coffee, like anything else in MODERATION is fine. If that were not true I would be long long dead (and probably from doing a lot of things NOT in moderation).
Debby
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