Aa
Dangers of Alpha Lipoic Acid IV Therapy !
Here is just one of the many dangers of ALA IV therapy:
This is from Pubmed which is considered to be very trustworthy by the medical community.
http://www.ncbi.nlm.nih.gov/pubmed/19616616
"We conclude that large doses of lipoic acid displace sulfhydryls from binding sites, resulting in depletion of serum cysteine, but also pose a methylation burden with severe depletion of liver S-adenosylmethionine and massive release of S-adenosylhomocysteine. These changes may have previously unrecognized deleterious (harmful) effects that should be investigated in both human disease and experimental models"
This is from Pubmed which is considered to be very trustworthy by the medical community.
http://www.ncbi.nlm.nih.gov/pubmed/19616616
"We conclude that large doses of lipoic acid displace sulfhydryls from binding sites, resulting in depletion of serum cysteine, but also pose a methylation burden with severe depletion of liver S-adenosylmethionine and massive release of S-adenosylhomocysteine. These changes may have previously unrecognized deleterious (harmful) effects that should be investigated in both human disease and experimental models"
I know this is off topic but can you elaborate about the HDL increase. what supplement did you take. I'm trying to raise my HDL. please dont say ALA injections :-)
thanks
thanks
If anyone is truly interested in the Berkson protocol I recommend go and see the
man and talk in person to his patients.
I have done that extensively and it was a great investment. Nothing like talking to
people who arrived there with blown up spleens and bleeding varcises ect....
and who are now doing much ,much better.
There is no article , study ect...... that can ever ever replace
real people and there real life stories and experiences.
By the way the amount of ALA given at Dr. Berkson is carefully
measured on case by case basis and he was FDA authorized
as the first physician ever to do ALA IVs in the 70s. Yes that
long !
man and talk in person to his patients.
I have done that extensively and it was a great investment. Nothing like talking to
people who arrived there with blown up spleens and bleeding varcises ect....
and who are now doing much ,much better.
There is no article , study ect...... that can ever ever replace
real people and there real life stories and experiences.
By the way the amount of ALA given at Dr. Berkson is carefully
measured on case by case basis and he was FDA authorized
as the first physician ever to do ALA IVs in the 70s. Yes that
long !
here' a good primer on lipoic acids...
http://en.wikipedia.org/wiki/Lipoic_acid
also note 1st paragraph, essential to life, you die without it...your gut and liver make it...
also note 309 studies follow this exegesis
309 medical studies...we report, you decide.
I can tell you this, I eat oatmeal for breakfast, sardines for a snack (many foods contain lipoic acids but because I am trying to keep my iron rich food consumption down, I choose to take a supplement and to choose foods rich in lipoic acid but not as high in iron (meat and broccoili are good but high iron.)
the supplement means I could increase my HDL profile without extra iron.
results=HDL rose nicely, LDL remained close to the same, overall profile is more hdl than ldl and low triglycerides now, before, not so.
other benefit= my neuropathy has reversed...I am no longer having the pins and needles or sharp stuck with a pin or dull deep aches I was having in my feet.
In fact, no hand pain the last couple months....very surprising.
my blood sugars are normal again, I have no need of type 2 meds so have discontinued them..
my seizures are much better than before and I am able to sleep again without the dopamine antagonist requip. Actually doing better without it since adding the ALA than I was doing with the requip and no ALA....(and no headaches like the requip gave me...so this really does settle down nerves, I can see why the MS community has come fully into this court.
all these corrections were well documented 50 years ago by Linus Pauling, Nobel Prize winner for his research into nutritional components.
they have been restudies and reconfirmed by researchers all over the world...
thank goodness people can pull up all the studies themselves and not rely on one or 2 abberant studies.
ALA is extensively used now by the diebetic and MS community because it is known to sooth nerves, reduce neuropathy, increase normal metabolic rate, reduce insulin resistance, and on and on. Lately it is receiving even more press for it's role as an antioxidant and possible benefits to liver patients in need of oxidative relief although it will be a while before we know for certain it's role here it appears to not compromise methalation unless overdosed form what I've seen and read.
The truth is, most anything will mess with methalation if you eat enough.
HR, medical doctor, tried to warn us about eating small amounts more often...not sure who took that advice but it's true, a compromised liver can't take as much or anything....so a word to the wise here.
Another essential known as PPC is also showing much promise in this area of oxidation relief as well as fibrosis reversal. If you stop to think about it it makes sense...abberant cells leads to more fibrosis, the sooner a cell goes rouge the sooner it causes distorted growth and scarring around it...
Obviously 309 studies is just the tip of the iceberg, but it is clear that oils do effect oxidation.
Anyone who owns a cast iron skillet knows how this works.
If you wash your pan, and leave it unoiled it will oxidize and start turning the tell tale red immediately, but if you season it with a little oil rubbed on, it will not oxidize.
Since oxygen interacts with stored iron in the liver, the idea is to keep oxidation low, as oxidation produced free radicals which are the precursors to cancer. The more free radicals formed, the more likely one will succumb to liver cancer. The free radical is what causes the cell to mutate into a cancer cell. Oxygen causes free radicals...we need it to breathe and live, but too much is deleterious.
Liver cancer is the 7th largest killer in the USA.
Ergo, low iron and good fats offer protection against the dreaded HCC to which 3-5 people reading this, out of every hundred reading, will succumb this year.
Since so much information exists as to the benefit, and only a spare few studies using overdosing exist to the contrary, I leave it to the reader to decide whether an ounce of prevention might be worth a pound of cure here.
BTW, liver cancer is almost never survived, it is a rapidly spreading almost always fatal condition so this might be something to think through in advance. If you have HCV you are at a much higher risk for liver cancer, higher than the 1 in 7 rate that exists in the general populace.
In fact at the HCV rate of 3-5% per annum that means in 10 years between 25% and 50% of us reading this will have developed HCCancer. That's scary stuff.
mb
http://en.wikipedia.org/wiki/Lipoic_acid
also note 1st paragraph, essential to life, you die without it...your gut and liver make it...
also note 309 studies follow this exegesis
309 medical studies...we report, you decide.
I can tell you this, I eat oatmeal for breakfast, sardines for a snack (many foods contain lipoic acids but because I am trying to keep my iron rich food consumption down, I choose to take a supplement and to choose foods rich in lipoic acid but not as high in iron (meat and broccoili are good but high iron.)
the supplement means I could increase my HDL profile without extra iron.
results=HDL rose nicely, LDL remained close to the same, overall profile is more hdl than ldl and low triglycerides now, before, not so.
other benefit= my neuropathy has reversed...I am no longer having the pins and needles or sharp stuck with a pin or dull deep aches I was having in my feet.
In fact, no hand pain the last couple months....very surprising.
my blood sugars are normal again, I have no need of type 2 meds so have discontinued them..
my seizures are much better than before and I am able to sleep again without the dopamine antagonist requip. Actually doing better without it since adding the ALA than I was doing with the requip and no ALA....(and no headaches like the requip gave me...so this really does settle down nerves, I can see why the MS community has come fully into this court.
all these corrections were well documented 50 years ago by Linus Pauling, Nobel Prize winner for his research into nutritional components.
they have been restudies and reconfirmed by researchers all over the world...
thank goodness people can pull up all the studies themselves and not rely on one or 2 abberant studies.
ALA is extensively used now by the diebetic and MS community because it is known to sooth nerves, reduce neuropathy, increase normal metabolic rate, reduce insulin resistance, and on and on. Lately it is receiving even more press for it's role as an antioxidant and possible benefits to liver patients in need of oxidative relief although it will be a while before we know for certain it's role here it appears to not compromise methalation unless overdosed form what I've seen and read.
The truth is, most anything will mess with methalation if you eat enough.
HR, medical doctor, tried to warn us about eating small amounts more often...not sure who took that advice but it's true, a compromised liver can't take as much or anything....so a word to the wise here.
Another essential known as PPC is also showing much promise in this area of oxidation relief as well as fibrosis reversal. If you stop to think about it it makes sense...abberant cells leads to more fibrosis, the sooner a cell goes rouge the sooner it causes distorted growth and scarring around it...
Obviously 309 studies is just the tip of the iceberg, but it is clear that oils do effect oxidation.
Anyone who owns a cast iron skillet knows how this works.
If you wash your pan, and leave it unoiled it will oxidize and start turning the tell tale red immediately, but if you season it with a little oil rubbed on, it will not oxidize.
Since oxygen interacts with stored iron in the liver, the idea is to keep oxidation low, as oxidation produced free radicals which are the precursors to cancer. The more free radicals formed, the more likely one will succumb to liver cancer. The free radical is what causes the cell to mutate into a cancer cell. Oxygen causes free radicals...we need it to breathe and live, but too much is deleterious.
Liver cancer is the 7th largest killer in the USA.
Ergo, low iron and good fats offer protection against the dreaded HCC to which 3-5 people reading this, out of every hundred reading, will succumb this year.
Since so much information exists as to the benefit, and only a spare few studies using overdosing exist to the contrary, I leave it to the reader to decide whether an ounce of prevention might be worth a pound of cure here.
BTW, liver cancer is almost never survived, it is a rapidly spreading almost always fatal condition so this might be something to think through in advance. If you have HCV you are at a much higher risk for liver cancer, higher than the 1 in 7 rate that exists in the general populace.
In fact at the HCV rate of 3-5% per annum that means in 10 years between 25% and 50% of us reading this will have developed HCCancer. That's scary stuff.
mb
As merrybe said, lipoic acid is an endogenous substance, meaning it is made by the body. It is essential to life. The liver is packed with it when we are young; our bodies make less of it as we grow older.
Lately you have been touting vitamin d on the board, which I approve of. As with lipoic acid, there is tons of evidence showing its therapeutic value. What would happen if you took a 20-40 X dose? It's called vitamin d toxicity. Same with vitamin a. Does that mean you shouldn't take safe doses of those vitamins?
What would a 20-40 X dose of INF/riba do to you? Obvious damage. Does that mean you shouldn't take the prescribed dose?
Lately you have been touting vitamin d on the board, which I approve of. As with lipoic acid, there is tons of evidence showing its therapeutic value. What would happen if you took a 20-40 X dose? It's called vitamin d toxicity. Same with vitamin a. Does that mean you shouldn't take safe doses of those vitamins?
What would a 20-40 X dose of INF/riba do to you? Obvious damage. Does that mean you shouldn't take the prescribed dose?
ALA like everything else can be overdosed. Dr. Berkson writes about it in his book.
I think they tested it on monkeys to see what happens if it gets overdosed.
I think they tested it on monkeys to see what happens if it gets overdosed.
Hi, folks,
Several posts have been removed from this discussion because they were off-topic and/or disrespectful. I appreciate your understanding.
Claire
MedHelp.org
Several posts have been removed from this discussion because they were off-topic and/or disrespectful. I appreciate your understanding.
Claire
MedHelp.org
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