Started GS 7977 & Ribavirin Trial

[HectorSF]

Hi all!

I started my HCV clinical trial treatment yesterday.

'An Open-Label Study to Explore the Clinical Efficacy of GS 7977 With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant'
NCT01559844

Primary Outcome Measures:
Determination of post-transplant virological response [ Time Frame: 36 Weeks ] [ Designated as safety issue: No ]
To determine if the administration of a combination of GS 7977 and ribavirin to HCV-infected subjects with hepatocellular carcinoma (HCC) meeting the MILAN criteria prior to undergoing liver transplantation for up to 24 weeks can prevent post-transplant re-infection as determined by a sustained post-transplant virological response (HCV RNA <LLoQ) at 12 weeks post-transplant.

Treatment Drugs:

2 200 mg of GS-7977 in morning
3 200 mg of Ribavirin in morning
3 200 mg of Ribavirin at night (12 hours later)


But I am now on treatment and will continue for 24 weeks or transplant, which ever comes first.

I stopped my TB treatment today. I will deal with TB after transplant.
I just had a cancer screen MRI/AFP and I am waiting for the results...

I can't believe that within 4 weeks I will have no viral load for the first time in 42 years!!! Once I become undetectable I will be looking for a transplant. This treatment is my best shot at curing my hepatitis C as a previous null-responder.

I heard through the grapevine that a trial with GS-7977 will be starting for post-transplant patients who are infected with hepatitis C. The cure rate now is only 30% using peg-interferon and ribavirin. Very poor results so we need more options.

Happy- :-))
Hector

[michelehen]

You are truely an inspiration to alot of people on here!  Sending good health your way - I lived in the bayarea for over 30 yrs caught Hep C in Vallejo in 1975  I miss the Bay Area wanting to sell and go home (Alameda).  lol

God Bless you Hector and many prayers your way!

[8nickers8]

Hector SF, Gosh, I sometimes feel like such a jerk.  I wish this thing allowed edits like facebook does.  My post was not in the right spirit and I asked a question that I shouldn't have, I apologize.  With all my heart, I wish you the best, brave Hector.  Somehow, it feels to me like you will be okay, and will have the rest of the life that you want.  Even though the greatest success so far with 7977 has been genotypes 2 and 3, they are still having successes with type I's too and also, Gilead is working feverishly on it.  I just went through it so if you have any questions at all, please feel free,  God Bless you., Donna

[8nickers8]

brotherdan, try to get on a clinical trial for 7977 and Riba.  Unbelievable cure rates for geno 2 and 3 and virtually no side effects.

[8nickers8]

I just finished the 7977 and Ribavirin.  What you will find so amazing is that there are virtually no side effects.  Anemia but they gave me a supplement that took care of that.  4 weeks out und and hoping for the best.  Wishing you the best.  Is all of that stuff you have related to HepC?

[BoceprevirGal]

   Whew-hooo!  You know what to do, take it one day at a time, and I will steal a line from OH;  "keep your eyes on the finish-line"
   You are in my prayers xoxo ~ Katy

[orphanedhawk]

I am so very happy for you ! This is such a wonderful opportunity to start anew within such a short time.
By next summer you will have a healthy new liver without the complication of knowing tx again will be in your future.
This is now a real possibility.
I'm sure I can say we are all rooting for you !!