Success in spite of failure

[domusic]

I am wondering if anyone knows of a case where someone on triple therapy who achieved EVR and early undetectable but had to discontinue treatment later, and "Still maintained an SVR". In other word was cured in spite of having to quit.

Domusic

[karinleem]

wow i was undetected at week 8 i am now in my 12 week and my blood counts are so low and my riba has been reduced and i am thime my doc will stop me i was wondering the same question about staying UND .i dont want it back but WBC is 1.9 RBC 2.76  hgb is 9.0    i hope that is true about the undetected saty gone .

[domusic]

I did SOC three years ago for 9 months with one Riba reduction due to anemia. My viral load went below the quantitative RNA test minimums but kept coming back positive on the Qualitative test. (Am I saying that right?). Anyway I am on triple therapy with VIC and because of the last treatment I am afraid that I will have problems this time also. My team (at the VA) says they're pretty sure I can get an SVR this time. If I become anemic I will opt for the Procrit to make sure I keep up all the meds for as long as possible.

Incidentally, I posted a week or so ago a question about elevated AFT. (low elevations) My Hepatologist cleared that question up by saying in people with liver disease and cirrhosis, when liver cells regenerate the process releases AFPs in to the blood.

Hey, thanks again for all of your responses . . .

Domusic

[stormy456]

Yes - there is a woman that has a blog that had terrible side effects, and quit at 8-1/2 weeks.  She is not SVR yet, but at 3 mos. post tx is still undetected, which makes the likelihood for SVR fairly good.  Of course, for each of those stories, there are the people that had to quit and relapsed, so if you can ride it out, of course you should.  My husband is in his 11th week of INC, and wishing like heck he could stop, but will ride out the full 24 weeks even though he was a serious EVR (UND at Day 5)  

[Willy50]

domusic wrote;
-----------------------
"a case where someone on triple therapy who achieved EVR and early undetectable."
-----------------------------------------

Just to make sure we are talking about the same thing....
An RVR is clear at 4 weeks, a Rapid Viral Response as opposed to an Early one.  

Are you saying in your example a person who does not RVR?  
Generally, the slower the response, the less the chances are of clearing.  This is also particularly true for people who would respond slow and end TX before the complete course of TX.

That first sentence doesn't make it clear if you mean "early" as in RVR or "Early" as in EVR.  
What week you cleared and at what week you ended could/would also affect SVR rates as well as genotype subtype (1a or 1b), damage, BMI, sex, race, etc.

willy

[Willy50]

Absolutely!!

Many of the early VX-950/Telaprevir/Incivek trial participants discontinued treatment when serious sides showed up.  The drug was new and people were being cautious.  Some people treated for a very short period of time, cleared and SVR'ed.

The preliminary results looks bad; discontinuations.  The bottom line however was that even a percentage of people who "failed" the treatment...... they had to dose reduce or discontinue treatment prematurely..... ended up succeeding.

There is a percentage of people w/ minimal damage, CC allele, maybe G-1b that will have a decent SVR rate with only 12 weeks of TX w/ Incivek and SOC.  I believe that vertex will check that out this year and we will see the results in a year and certainly within 2 years.  At least Vertex has talked about this possible treatment trial.

willy

[willbb]

Other than patients in trials there are no SVR"s yet. It is still too early.
The first SVR"s treating clinically will be in the next 3 or 4 months.

Will