Aa
fibrosis stages monitoring - post tx
I got my Fibroscan score 10.4 kPa and staged as F2-F3.
The reference values used are:
is F4.
Scan completed with valid scan -10 with success rate 100% so doc said it was a pretty valid scan.
This was my first and only scan two weeks after tx. I don't have any liver histology before, this is the first starting point in monitoring and don't know if the scaring stopped or went down during tx..
And I was told that the fibrosis could go down about two stages in time.
I was wondering if inflammation and fibrosis progression stop after UND and if there is no portal hypertension related complications, the existing scars really matter? Or it is important to get back down to the early stages because there are issues with the scars? Yes, it would be good to have the original nice smooth liver back though.
Can you share the post tx liver histology healing time line? Thanks.
The reference values used are:
is F4.
Scan completed with valid scan -10 with success rate 100% so doc said it was a pretty valid scan.
This was my first and only scan two weeks after tx. I don't have any liver histology before, this is the first starting point in monitoring and don't know if the scaring stopped or went down during tx..
And I was told that the fibrosis could go down about two stages in time.
I was wondering if inflammation and fibrosis progression stop after UND and if there is no portal hypertension related complications, the existing scars really matter? Or it is important to get back down to the early stages because there are issues with the scars? Yes, it would be good to have the original nice smooth liver back though.
Can you share the post tx liver histology healing time line? Thanks.
good luck with a quick recovery and on good news ahead. After only 24w it's probably premature to expect much improvement but this should serve as a good baseline for future monitoring . I'm in the same neighborhood (last FS 10). If you read around on elastography you'll see it's a fairly imprecise measurement - lots of different scales/cutoffs and the standard errors on the average value within a stage can be a couple of units. Low IQR and high success rate on the readings help but there's a real limit to what can be reliably measured (though as patients we'd like to see staging worked out to three significant figures). The main point though is that there's nothing better. Best strategy is to keep checking once or twice a year and look for a trend among the noise. Also consider testing hyaluronic acid (HA), a serum maker for fibrosis, and check for changes over time (and you don't have to leave the country!)
http://www.ncbi.nlm.nih.gov/pubmed/18371145
BTW - for some recent dramatic evidence of post-tx FS-based reversal (here in the context of HBV) see the abstracts at the end of thread:
http://www.medhelp.org/posts/Hepatitis-C/the-corrections/show/1378750
http://www.ncbi.nlm.nih.gov/pubmed/18371145
BTW - for some recent dramatic evidence of post-tx FS-based reversal (here in the context of HBV) see the abstracts at the end of thread:
http://www.medhelp.org/posts/Hepatitis-C/the-corrections/show/1378750
Wait a min, I read the color code bar chart a little off. For HCV, less than 7 is graded as F0-F1, is it is not just straight F0. Sorry for the confusion.
fretboard, I am post two weeks EOT and UNDed. For SVR, it is too early to tell I guess. I took the Scan just because it is available while I am travelling abroad. Yes, I am glad that I caught the fibrosis progression just in time and did tx.
Bali, those reference values are printed on my Fibroscan result record from the hospital. They are printed on a bar chart. Interestingly they grade differently for each different liver disease and infections. For example, in HCV-HIV Co-infection, there is no FI and F2 in kPa to Metavir score conversion. From 7 to 12.5 is graded as F2-F3.
I would say you are F0 for 5.6, don't you think?
jusjames, thx.
Bali, those reference values are printed on my Fibroscan result record from the hospital. They are printed on a bar chart. Interestingly they grade differently for each different liver disease and infections. For example, in HCV-HIV Co-infection, there is no FI and F2 in kPa to Metavir score conversion. From 7 to 12.5 is graded as F2-F3.
I would say you are F0 for 5.6, don't you think?
jusjames, thx.
where are those reference values from ?
I did a baseline FS (5.9kPa) , 12wk FS (5.6kPa) and I will do one @ EOT and 6 months after (same machine/operator/ average out of 10 readings)
According to your reference values I am F0.
.
I did a baseline FS (5.9kPa) , 12wk FS (5.6kPa) and I will do one @ EOT and 6 months after (same machine/operator/ average out of 10 readings)
According to your reference values I am F0.
.
Well I can only guess that you SVR'd correct? It's only been a couple weeks since you stopped tx so it's waaay too soon to see any signs of reversal. That would be my guess. From the reading of the fibroscan it looks like you got tx just in time! Why would you get a fibroscan two weeks after tx tho'? Maybe someone else will have Fibroscan info for you but I've never had one.
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