trial for teleprevir

[Renee543]

Hello, I hope I am not asking too many questions but I just went to the govt clinical trials site and found one here in the city where I live. It is for teleprevir but it is a phase lll for twice daily instead of every 8 hrs. It is trial # VX950C211. Is there anyone who knows anything about this trial for Teleprevir? Would it be a good one to get into?
I see my Liver doc this week but I think I may be close to a stage 3 because of my low platelets and other blood counts. The doc I see will be a govt.ran healthcare and  will only offer the regular interferon and Rib. Would it be better to do that or try and get in a study like this with the Teleprevir? Any help would be most appreciated. thanks

[Renee543]

I am going to wait until Summer and get the txt from the doctor. Thanks for the info on the trials.

[burned74]

I dont see why you would want to go into a trial for Teleprevir right now. The approval is slated for this summer.

Many trials prohibit the use of EPO and Neupo if your red or white BC count goes down. If you  are therefore forced to  reduce your dose of Riba or Peg, you also reduce the chances of SVR and, most importantly, your virus becomes resistant to Tele so you cant retreat.

Further there are some things that legitimate studies have shown will slightly increase your chances of SVR and trials prohibit these. For example :Predose Riba to allow the levels to be built up before slamming the virus with peg, induction therapy with Peg (ie taking it every 5 days rather than every week for the first month or so).


Everyone is different, but, for me, waiting until summer or fall for Tele to be available and adding these little extras is a better bet.

[Renee543]

Heard back from trial...no openings...oh well. Wait for Summer and hope the Gastro gets the meds like he says he will.

[Renee543]

Just waiting to hear back from them. If I don't they are treating at the Hepc clinic at the hospital in July.

[Mary4now]

Wow, that sounds good

[lapis]

It looks like a good trial to me.  You know you're getting the Telaprevir, which is much better than taking the chance of getting a placebo, and you're getting SOC as well.  You're getting the same daily dosing of Tela either way, but the doses are divided into either twice a day or three times a day.  It's a phase 3 trial, which means that Telaprevir has already gone through a lot of testing and much is known about its safety and efficacy.  And, there are provisions to treat for 24 or 48 weeks, which means they'll continue your tx for the whole 48 weeks if needed.  That's just my two cents worth, I'm sure others will chime in.