Question Title: Pedal clonus

I am a 57 yr. old healthy white male, Ashkenazic jewish heritage. I take
50 mg. Cozaar for mild hypertension probably secondary to 35 lbs. excess
weight and smoking 1 pack of cigarettes/day. Active person, cycling 4x/wk.
I also take 20 mg. Prozac/day for chronic depression. I have been on Prozac
for only 1 month. I also take Xanax only when needed (0.5 mg) for paraspinal
muscle spasms secondary to vertebral biomechanical instability as a result
of an injury to the left Hallux 15 yrs. ago (average daily dose of Xanax
is about 0.125 mg).

QUESTION: Can my clonus be a result of mixing Cozaar, Prozac, Xanax and
about 22 ozs. of standard beer/day (alcohol content = 3.4%) ??
THANKS FOR YOUR HELP. !!!

Not sure exactly what your doctor's report says - "2+" is actually a neurologist's description for a normal reflex. Clonus is another thing and basically means that foot shakes rhythmically on reflex testing. It is a nonspecific sign of hyperactive reflexes - some nonsustained jerks of clonus at the ankle is sometimes seen in normal people. You can ask your doctor what he thinks the significance of it, but if isolated (i.e. no weakness, sensory complaints, urinary problems) it probably is not significant. It's something that has to be evaluated in the setting of the entire neurologic exam. Sometimes as we all age, we get a little neck arthritis which can cause active reflexes or mild clonus, but if no other problems or exam findings exist, no further workup is done. As for your mixture of the above medications (especially Xanax and alcohol, you should alays be cautious, but it is probably unrelated to the reflex changes you note