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I refused to take Celebrex, and this is the first time I have ever done this, and I'm 59. My doctor recently prescribed it for pain in my shoulder, and it came with a full page (both sides) of warnings of side affects. Even worse, should you suffer any side affects they had a toll free number for you to contact the FDA! So, it appears to me that they aren't sure about keeping this medication on the market. I also have done extensive research on HRT and would not take this either, nor does my doctor recommend it. My husband takes the metformin, lisinopril and nexium with no problems. Your supplements are fine, but too much pain medicine can affect your stomach and liver, and may be the culprit here. Good luck to you.