If a child tests negative for HBsAG early in life and has had all the doses of the vaccine plus one and no HBIG, is there a chance that later in life they could test Postive if born to a HBsAG+ mother?
you must test for hbsab after vaccine, not hbsag.if hbsab is detactable the baby is immune, booster dose every 10 years is better if hbsab declines less than 10miu/ml
it is immediately possible that:
if mother was hbeag pos and detactable hbvdna it is possible that vaccine fails by hbsag mutation.in this case hbsab antibody is useless, this mutation event is rare
be also sure to avoid very old assays which cannot detect hbsag mutants, use abbott architect which is available since 2005 or earlier or the new hbsag roches or siemens machines so you will know 100% if hbsag is negative and hbsab positive and vaccine worked.in this case the baby is 100% immune
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