Aa
Started GS 7977 & Ribavirin Trial
Hi all!
I started my HCV clinical trial treatment yesterday.
'An Open-Label Study to Explore the Clinical Efficacy of GS 7977 With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant'
NCT01559844
Primary Outcome Measures:
Determination of post-transplant virological response [ Time Frame: 36 Weeks ] [ Designated as safety issue: No ]
To determine if the administration of a combination of GS 7977 and ribavirin to HCV-infected subjects with hepatocellular carcinoma (HCC) meeting the MILAN criteria prior to undergoing liver transplantation for up to 24 weeks can prevent post-transplant re-infection as determined by a sustained post-transplant virological response (HCV RNA <LLoQ) at 12 weeks post-transplant.
Treatment Drugs:
2 200 mg of GS-7977 in morning
3 200 mg of Ribavirin in morning
3 200 mg of Ribavirin at night (12 hours later)
But I am now on treatment and will continue for 24 weeks or transplant, which ever comes first.
I stopped my TB treatment today. I will deal with TB after transplant.
I just had a cancer screen MRI/AFP and I am waiting for the results...
I can't believe that within 4 weeks I will have no viral load for the first time in 42 years!!! Once I become undetectable I will be looking for a transplant. This treatment is my best shot at curing my hepatitis C as a previous null-responder.
I heard through the grapevine that a trial with GS-7977 will be starting for post-transplant patients who are infected with hepatitis C. The cure rate now is only 30% using peg-interferon and ribavirin. Very poor results so we need more options.
Happy- :-))
Hector
I started my HCV clinical trial treatment yesterday.
'An Open-Label Study to Explore the Clinical Efficacy of GS 7977 With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant'
NCT01559844
Primary Outcome Measures:
Determination of post-transplant virological response [ Time Frame: 36 Weeks ] [ Designated as safety issue: No ]
To determine if the administration of a combination of GS 7977 and ribavirin to HCV-infected subjects with hepatocellular carcinoma (HCC) meeting the MILAN criteria prior to undergoing liver transplantation for up to 24 weeks can prevent post-transplant re-infection as determined by a sustained post-transplant virological response (HCV RNA <LLoQ) at 12 weeks post-transplant.
Treatment Drugs:
2 200 mg of GS-7977 in morning
3 200 mg of Ribavirin in morning
3 200 mg of Ribavirin at night (12 hours later)
But I am now on treatment and will continue for 24 weeks or transplant, which ever comes first.
I stopped my TB treatment today. I will deal with TB after transplant.
I just had a cancer screen MRI/AFP and I am waiting for the results...
I can't believe that within 4 weeks I will have no viral load for the first time in 42 years!!! Once I become undetectable I will be looking for a transplant. This treatment is my best shot at curing my hepatitis C as a previous null-responder.
I heard through the grapevine that a trial with GS-7977 will be starting for post-transplant patients who are infected with hepatitis C. The cure rate now is only 30% using peg-interferon and ribavirin. Very poor results so we need more options.
Happy- :-))
Hector
Hector,
I don't know you well yet as I'm on day 10 of triple therapy, but you have given me great advice and have so much to contribute to this forum. Everyone relies on you I can see as the expert. Congratulations and the very best results are wished for you. Keep us informed. I hope all goes well. I just found out my biblirubin is high so I'm going in next Wednesday to get it tested again. My doctor says this happens with the onset of treatment, but we have to watch it. He's hoping it settles back down. I got a UTI immediately so been on antibiotics for a few days and another 5 to go. Just want I needed! Take care and best to you....thanks for the great advice.
pat
I don't know you well yet as I'm on day 10 of triple therapy, but you have given me great advice and have so much to contribute to this forum. Everyone relies on you I can see as the expert. Congratulations and the very best results are wished for you. Keep us informed. I hope all goes well. I just found out my biblirubin is high so I'm going in next Wednesday to get it tested again. My doctor says this happens with the onset of treatment, but we have to watch it. He's hoping it settles back down. I got a UTI immediately so been on antibiotics for a few days and another 5 to go. Just want I needed! Take care and best to you....thanks for the great advice.
pat
Well you know how I feel about this - I'm absolutely thrilled for you. I'm so looking forward to reading that UND report, which is sure to be coming very soon. You've been so incredibly supportive of everyone here, it's your turn to be cured. Excellent...
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